List of works by Lieve Naesens

(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection.

scientific article

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

scientific article

2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections

scientific article published on September 2002

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

scientific article published on 15 November 2013

4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action

scientific article

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

scientific article

6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity

scientific article published in October 2004

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs

scientific article published on January 2011

9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo

scientific article published on December 1989

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

scientific article

<i>In Vitro</i> Characterization of the Carbohydrate-Binding Agents HHA, GNA and UDA as Inhibitors of Influenza a and B Virus Replication

scientific article published on 07 December 2020

A few atoms make the difference: synthetic, CD, NMR and computational studies on antiviral and antibacterial activities of glycopeptide antibiotic aglycon derivatives.

scientific article

A versatile salicyl hydrazonic ligand and its metal complexes as antiviral agents

scientific article published on 27 May 2015

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

scientific article

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

scientific article published on 22 September 2014

Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.

scientific article

Adefovir dipivoxil

Adefovir serum levels do not differ between responders and nonresponders

scientific article published on 07 January 2011

Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients.

scientific article published in August 2005

Airway proteases: an emerging drug target for influenza and other respiratory virus infections.

scientific article

Alkylamino derivatives of N-benzylpyrazine-2-carboxamide: synthesis and antimycobacterial evaluation

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

scientific article

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.

scientific article published on 2 November 2017

An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease

scientific article published on 4 December 2014

Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion.

scientific article published on 8 December 2017

Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo.

scientific article published on February 2001

Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.

scientific article

Antiadenovirus activities of several classes of nucleoside and nucleotide analogues

scientific article published on March 2005

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases

scientific article published on 27 July 2015

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

scientific article

Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors

scientific article

Antitumor Potential of Acyclic Nucleoside Phosphonates

scientific article published on 01 April 1999

Antiviral activity and metal ion-binding properties of some 2-hydroxy-3-methoxyphenyl acylhydrazones

scientific article published on 5 December 2017

Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts

scientific article published on December 2006

Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.

scientific article published on December 1995

Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds

scientific article published on 14 February 2007

Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.

scientific article

Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines

scientific article published on January 2005

Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses

scientific article published on 18 April 2006

Antiviral therapies on the horizon for influenza

scientific article

Antiviral therapy for adenovirus infections.

scientific article

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

scientific article

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin.

scientific article

Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity

scientific article published in March 2002

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

scientific article published on 30 June 2012

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents

scientific article

Azapropellanes with anti-influenza a virus activity.

scientific article

Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers

scientific article

Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir)

scientific article published on 02 April 2019

Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection.

scientific article

Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay

scientific article published in May 2003

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N'-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

scientific article published on 20 March 2017

Cidofovir is active against human papillomavirus positive and negative head and neck and cervical tumor cells by causing DNA damage as one of its working mechanisms

scientific article published on 16 June 2016

Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage

scientific article

Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice

scientific article

Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity.

scientific article published on 27 March 2010

Clinical features and treatment of adenovirus infections

scientific article

Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity

scientific article published in March 2002

Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers

scientific article published on 01 February 1998

Conservation of HHV-6 DNA polymerase processivity factor sequence and predicted structure suggests it as a target for antiviral development

scientific article published in June 2010

Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.

scientific article published on June 1997

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase

scientific article published on 27 October 2016

Cytostatic and antiviral activity evaluations of hydroxamic derivatives of some non-steroidal anti-inflammatory drugs

scientific article

Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii

scientific article published on 20 November 2009

Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity

scientific article published on 15 January 2009

Design and synthesis of bioactive 1,2-annulated adamantane derivatives.

scientific article published on 9 July 2008

Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines

scientific article published on 12 August 2010

Design and synthesis of bioactive adamantane spiro heterocycles

scientific article published on 6 May 2007

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

scientific article published on 06 December 2019

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.

scientific article published on 21 November 2017

Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives

scientific article published on 17 July 2019

Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study.

scientific article published in October 2009

Diclofenac-Based Hydrazones and Spirothiazolidinones: Synthesis, Characterization, and Antimicrobial Properties.

scientific article published on 30 March 2017

Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet

scientific article

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

scientific article

Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents

scientific article published on 25 August 2011

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors

scientific article published on 05 December 2019

Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis.

scientific article published on 29 August 2016

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

scientific article published on 30 June 2014

Editorial overview: Antiviral strategies: Antiviral drug design: creating new ideas against old and new bugs.

scientific article

Effects of 2',3'-dideoxycytidine and 2',3'-dideoxycytidine 5'-triphosphate on phospholipid metabolism in permeabilized rat hepatocytes

scientific article published on 01 September 1997

Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

scientific article published on 01 May 1992

Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice

scientific article published on 01 February 1993

Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus

scientific article published in February 1998

Emerging antiviral strategies to interfere with influenza virus entry

scientific article

Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity

scientific article published on 19 October 2007

Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells

scientific article published on 11 September 2013

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA

scientific article published on 01 September 1999

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

scientific article published on 05 April 2011

Favipiravir Does Not Inhibit Chikungunya Virus Replication in Mosquito Cells and Aedes aegypti Mosquitoes

scientific article published in 2021

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

scientific article

First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach

scientific article

Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

scientific article published on 12 December 2019

Heterocyclic rimantadine analogues with antiviral activity

scientific article published on 24 January 2006

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

scientific article published on 27 April 2017

Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance

scientific article published in October 2004

Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle

scientific article published in February 2004

Identification and Mechanistic Studies on a Novel Class of Influenza Virus Fusion Inhibitors

scientific article published in 2009

Identification of Bicyclic Sulfone Inhibitors of HHV-6 Targeting the HHV-6 U77 Helicase

scientific article published in 2011

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening

scientific article published on 27 July 2018

In Vitro, Ex Vivo, and In Situ Intestinal Absorption Characteristics of the Antiviral Ester Prodrug Adefovir Dipivoxil

scientific article published on 01 August 2000

In search of effective anti-HHV-6 agents

scientific article published on December 2006

In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma

scientific article published on 01 January 1998

In vivo Antiretroviral Efficacy of Oral bis(POM)-PMEA, the bis(Pivaloyloxymethyl)prodrug of 9-(2-Phosphonylmethoxyethyl) adenine (PMEA)

Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway

scientific article published on 14 February 2019

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study

scientific article published on 01 July 1999

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents

scientific article

Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates

scientific article published on June 1999

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities.

scientific article published on 20 August 2016

Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs

scientific article

Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus

scientific article published in March 1990

Interaction between mouse adenovirus type 1 and cell surface heparan sulfate proteoglycans

scientific article

Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781.

scientific article published in March 2002

Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.

scientific article

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

scientific article published on 19 August 2008

Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin.

scientific article

Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven

scientific article published in 2006

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

scientific article published on September 2015

List of Contributors

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

scientific article

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

scientific article

Mechanistic Studies on a Novel Hydrophobic Derivative of Aglycoristocetin with Potent and Broad Activity Against Influenza Viruses

article published in 2011

Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene

scientific article published on 18 September 2018

Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).

scientific article published in May 2003

Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety

scientific article published on January 1998

Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N- methyl-thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dio xide).

scientific article published on July 1993

Metal-chelating 2-hydroxyphenyl amide pharmacophore for inhibition of influenza virus endonuclease

scientific article published on 25 November 2013

Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives

scientific article published on 12 October 2012

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

scientific article published on February 2009

Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor.

scientific article published on 21 June 2006

Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections

scientific article

Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease

scientific article (publication date: October 2013)

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

scientific article published on 11 August 2016

N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties

scientific article published on 01 July 1999

New antivirals - mechanism of action and resistance development

scientific article

New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode.

scientific article published on 14 April 2015

Norbornane-based nucleoside and nucleotide analogues locked in North conformation

scientific article published on 15 November 2014

Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors

scientific article published on 18 September 2019

Novel indole–flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus

Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin

scientific article

Partial purification and characterization of mitochondrial DNA polymerase from Plasmodium falciparum.

scientific article

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

scientific article published on August 1997

Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.

scientific article published on January 2000

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy

scientific article published in June 2010

Polycyclic N-benzamido imides with potent activity against vaccinia virus.

scientific article published on December 2010

Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats

scientific article published on 01 May 1998

Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model

scientific article published on 01 October 1998

Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.

scientific article published on January 2004

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus

scientific article published on 22 October 2007

Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent.

scientific article published on July 1998

Prodrugs of the Phosphoribosylated Forms of Hydroxypyrazinecarboxamide Pseudobase T-705 and Its De-Fluoro Analogue T-1105 as Potent Influenza Virus Inhibitors

scientific article published on 03 July 2018

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates

scientific article published on 09 October 2015

Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase

scientific article published on 19 September 2018

Quantitative analysis of human herpesvirus 6 cell tropism

scientific article

Recovery of humoral immunity is critical for successful antiviral therapy in disseminated mouse adenovirus type 1 infection

scientific article published on 11 February 2008

Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity

scientific article published on 29 June 2020

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1

scientific article published on 25 January 2016

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)

scientific article

Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir

scientific article published in September 2002

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.

scientific article published on 22 June 2013

Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).

scientific article published on March 1998

Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: synthesis and antiviral studies.

scientific article published on 16 June 2014

Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo

scientific article

Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus

scientific article published on 18 April 2017

Solid state properties of pure UC-781 and solid dispersions with polyvinylpyrrolidone (PVP K30).

scientific article published in August 2001

Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase

scientific article published in February 2002

Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig

scientific article published on 01 November 1998

Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents

scientific article published on 22 August 2018

Structure–Activity Relationship of a Novel Class of Aglycoristocetin Derivatives with Potent and Broad Activity Against Influenza Viruses

scientific article published in 2009

Study of different substituted cyclic and acyclic benzylpronucleotides of d4T relative to their hydrolytic stability and antiviral activity.

scientific article published in May 2003

Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug-resistant mutants.

scientific article

Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis

scientific article published in February 2005

Superior inhibition of influenza virus hemagglutinin-mediated fusion by indole-substituted spirothiazolidinones

scientific article published on 08 November 2019

Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.

scientific article

Synthesis and Antimicrobial Evaluation of 6-Alkylamino-N-phenylpyrazine-2-carboxamides

scientific article

Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine

scientific article published in 2008

Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides.

scientific article published on 14 May 2015

Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses

scientific article published on 25 March 2020

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.

scientific article published on 16 August 2017

Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections

scientific article published on 20 January 2015

Synthesis and Structure-Activity Relationship of N-(3-Oxo-1-Thia-4-Azaspiro[4.5]Decan-4-Yl)Carboxamide Inhibitors of Influenza Virus Hemagglutinin Mediated Fusion

Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent

scientific article published on 29 July 2008

Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.

scientific article published on 26 August 2008

Synthesis and antiviral evaluation of bisnoradamantane sulfites and related compounds

scientific article published on 01 March 2011

Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones

scientific article published on 8 December 2015

Synthesis and anti‐coronavirus activity of a series of 1‐thia‐4‐azaspiro[4.5]decan‐3‐one derivatives

scientific article published on 9 May 2019

Synthesis and biological evaluation of lipophilic teicoplanin pseudoaglycon derivatives containing a substituted triazole function.

scientific article published on 29 June 2016

Synthesis and biological evaluation of purine 2'-fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents

scientific article

Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus

scientific article published on 28 January 2012

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs

scientific article published on 24 May 2017

Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones.

scientific article

Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.

scientific article published on 13 February 2009

Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

scientific article

Synthesis of 1,2-annulated adamantane heterocycles: structural determination studies of a bioactive cyclic sulfite

Synthesis of a cluster-forming sialylthio-D-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase

scientific article published on 18 April 2014

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

scientific article published on 2 December 2011

Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents

scientific article published on October 2010

Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

scientific article published on 25 October 2012

Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities

scientific article

Synthesis of novel aza-analogues of tiazofurin with 2-[5,5-bis(hydroxymethyl)pyrrolidin-2-yl] framework as sugar mimic.

scientific article published in January 2012

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

scientific article published on 02 June 2018

Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues.

scientific article

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

scientific article

Therapeutic Approaches to HHV-6 Infection

Thermal characterization of the antiviral drug UC-781 and stability of its glass

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

scientific article published on 01 April 1997

Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].

scientific article

Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).

scientific article published in May 1998

Update on human herpesvirus 6 biology, clinical features, and therapy

scientific article

Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.

scientific article

Visna in sheep as a model for chemotherapy of lentiviral central nervous system infections

scientific article published on 01 January 1998

synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors

scientific article published on 20 February 2012

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