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List of works by Hiromi Sakai

A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors

scientific article

A transient inflammatory reaction in the lung after experimental hemorrhagic shock and resuscitation with a hemoglobin-vesicles solution compared with rat RBC transfusion.

scientific article published in September 2009

Academia-Industry Collaboration in Blood Substitute Development: Issues, Case Histories and a Proposal

article

Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks

scientific article published in March 2006

Acute 40% exchange-transfusion with hemoglobin-vesicles in a mouse pneumonectomy model.

scientific article

Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity

scientific article published on 26 August 2010

An automated method for cell-free layer width determination in small arterioles

scientific article published on 21 January 2011

Analysis of Dimeric αβ Subunit Exchange between PEGylated and Native Hemoglobins (α2β2 Tetramer) in an Equilibrated State by Intramolecular ββ-Cross-Linking

scientific article published on 12 July 2018

Antioxidative Pseudoenzymatic Mechanism of NAD(P)H Coexisting with Oxyhemoglobin for Suppressed Methemoglobin Formation

scientific article published on 28 February 2019

Application of Perfusate With Human-Derived Oxygen Carrier Solution Under Subnormothermic Machine Perfusion for Donation After Cardiac Death Liver Grafts in Pigs

scientific article published on 20 March 2018

Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model

scientific article

Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry

scientific article published on 10 February 2009

Biocompatibility of HbV: Liposome-Encapsulated Hemoglobin Molecules-Liposome Effects on Immune Function.

scientific article published on 28 June 2017

Biocompatibility study of hemoglobin vesicles, cellular-type artificial oxygen carriers, with human umbilical cord hematopoietic stem/progenitor cells using an in vitro expansion system.

scientific article

Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity

scientific article published on 01 November 2018

Capillary blood flow during severe hemodilution observed by a noninvasive transcutaneous technique using flash epi-illumination.

scientific article

Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties

scientific article published on 27 October 2016

Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis.

scientific article published on 6 May 2014

Cardiopulmonary hemodynamic responses to the small injection of hemoglobin vesicles (artificial oxygen carriers) in miniature pigs

scientific article

Chapter 19 Hemoglobin-Vesicles as an Artificial Oxygen Carrier

scientific article published on 01 January 2009

Characteristics of Hb-vesicles and encapsulation procedure

scientific article published on 01 January 1994

Characteristics of bovine hemoglobin as a potential source of hemoglobin-vesicles for an artificial oxygen carrier.

scientific article

Complete deoxygenation from a hemoglobin solution by an electrochemical method and heat treatment for virus inactivation.

scientific article published in January 2002

Constriction of resistance arteries determines l-NAME-induced hypertension in a conscious hamster model

scientific article

Convenient method to purify hemoglobin

scientific article published on 01 January 1994

Detection of lipopolysaccharide in hemoglobin-vesicles by Limulus amebocyte lysate test with kinetic-turbidimetric gel clotting analysis and pretreatment of surfactant.

scientific article

Effect of the cellular-type artificial oxygen carrier hemoglobin vesicle as a resuscitative fluid for prehospital treatment: experiments in a rat uncontrolled hemorrhagic shock model

scientific article published in August 2012

Effects of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hematological responses, complement and anaphylactic reactions in rats

scientific article published in January 2007

Effects of poly(ethyleneglycol)-modified hemoglobin vesicles on agonist-induced platelet aggregation and RANTES release in vitro.

scientific article

Efficacy of Resuscitative Transfusion With Hemoglobin Vesicles in the Treatment of Massive Hemorrhage in Rabbits With Thrombocytopenic Coagulopathy and Its Effect on Hemostasis by Platelet Transfusion

scientific article published on 01 September 2018

Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier

scientific article published on 14 November 2007

Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis

scientific article

Fluid resuscitation of hemorrhagic shock with hemoglobin vesicles in Beagle dogs: pilot study.

scientific article published in February 2012

Fluid resuscitation with hemoglobin vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model.

scientific article published on 12 January 2011

Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia or inflammatory responses in moderate hemorrhagic shock

scientific article published on 01 December 2006

Gas bioengineering using hemoglobin-vesicles for versatile clinical applications.

scientific article published on January 2011

Haemodynamics and oxygen tension in the microcirculation of ischaemic skin flaps after neural blockade and haemodilution.

scientific article published on October 1999

Hemoglobin Vesicles prolong the time to circulatory collapse in rats during apnea

scientific article

Hemoglobin encapsulation in vesicles retards NO and CO binding and O2 release when perfused through narrow gas-permeable tubes.

scientific article published on 31 December 2009

Hemoglobin vesicles containing methemoglobin and L-tyrosine to suppress methemoglobin formation in vitro and in vivo

scientific article published in September 2006

Hemoglobin vesicles improve wound healing and tissue survival in critically ischemic skin in mice

scientific article published on 02 July 2009

Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamster flap tissue

scientific article published in March 2007

Hemoglobin vesicles, polyethylene glycol (PEG)ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice

scientific article published on 13 August 2009

Hemoglobin-vesicles as a transfusion alternative.

scientific article published on November 2006

Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats.

scientific article published in February 2004

Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-alpha

scientific article published in September 2004

Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.

scientific article published on 13 August 2010

Hidden Antioxidative Functions of Reduced Nicotinamide Adenine Dinucleotide Coexisting with Hemoglobin

scientific article

Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model.

scientific article published in September 2009

Impact of human-derived hemoglobin based oxygen vesicles as a machine perfusion solution for liver donation after cardiac death in a pig model

scientific article published on 11 December 2019

In vivo evaluation of electron mediators for the reduction of methemoglobin encapsulated in liposomes using electron energies produced by red blood cell glycolysis.

scientific article published on 6 November 2017

Increased viscosity of hemoglobin-based oxygen carriers retards NO-binding when perfused through narrow gas-permeable tubes

scientific article published on 16 December 2010

Influence of erythrocyte aggregation at pathological levels on cell-free marginal layer in a narrow circular tube

scientific article published on 20 October 2014

Influence of hemoglobin vesicles, cellular-type artificial oxygen carriers, on human umbilical cord blood hematopoietic progenitor cells in vitro.

scientific article published in January 2009

Inhibition effect of aggregation of phospholipid vesicles by incorporation of glycolipids

International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids–A White Paper

article

Intravenous injection of artificial red cells and subsequent dye laser irradiation causes deep vessel impairment in an animal model of port-wine stain

scientific article published on 15 March 2018

Is hemoglobin in hemoglobin vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?

scientific article published on 5 August 2005

Liposomal Artificial Red Blood Cell-Based Carbon Monoxide Donor Is a Potent Renoprotectant against Cisplatin-Induced Acute Kidney Injury

scientific article published in 2021

Liposomal microparticle injection can induce myeloid-derived suppressor cells (MDSC)-like cells in vivo.

scientific article published on 5 April 2017

Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model

scientific article published on 22 August 2012

Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury.

scientific article

Mechanism of flocculate formation of highly concentrated phospholipid vesicles suspended in a series of water-soluble biopolymers.

scientific article published in August 2009

Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.

scientific article published in August 2004

Methemoglobin formation in hemoglobin vesicles and reduction by encapsulated thiols

scientific article published on 01 July 1997

Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier.

scientific article published in September 2012

Model mice for Presbyterian hemoglobinopathy (Asn(beta108)-->Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb

scientific journal article

NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers

scientific article published on 20 March 2008

New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue.

scientific article published in April 2005

Normothermic preservation of the rat hind limb with artificial oxygen-carrying hemoglobin vesicles

scientific article published in April 2015

One-year observation of Wistar rats after intravenous infusion of hemoglobin-vesicles (artificial oxygen carriers).

scientific article published in January 2007

Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity

scientific article published on 27 November 2002

Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution.

scientific article published on 24 November 2004

Peculiar flow patterns of RBCs suspended in viscous fluids and perfused through a narrow tube (25 microm).

scientific article

Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture conditions

scientific article published on 6 January 2011

Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin vesicles as an artificial oxygen carrier.

scientific article

Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model

scientific article published on 24 February 2009

Phase separation of polymerized mixed liposomes: analysis of release behavior of entrapped molecules with skeletonization

Photoreduction of methemoglobin by irradiation in the near-ultraviolet region

scientific article published on 01 November 2000

Photosensitizer Effects of Artificial Red Cells on Dye Laser Irradiation in an Animal Model Assuming Port-Wine Stain Treatment.

scientific article

Physical properties of hemoglobin vesicles as red cell substitutes

scientific article published on 01 January 1996

Physiologic responses to exchange transfusion with hemoglobin vesicles as an artificial oxygen carrier in anesthetized rats: changes in mean arterial pressure and renal cortical tissue oxygen tension.

scientific article

Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days.

scientific article

Poly(ethylene glycol)-Conjugation and Deoxygenation Enable Long-Term Preservation of Hemoglobin-Vesicles as Oxygen Carriers in a Liquid State

scientific article published on 01 May 2000

Poly(ethylene glycol)-conjugated phospholipids in aqueous micellar solutions: hydration, static structure, and interparticle interactions

scientific article published in February 2007

Potential New Non-Invasive Therapy Using Artificial Oxygen Carriers for Pre-Eclampsia

scientific article

Potential electron mediators to extract electron energies of RBC glycolysis for prolonged in vivo functional lifetime of hemoglobin vesicles

scientific article published on 10 March 2015

Present Situation of the Development of Cellular-Type Hemoglobin-Based Oxygen Carrier (Hemoglobin-Vesicles) ⬇️

scientific article published on September 1, 2012

Pretreatment of serum containing hemoglobin vesicles (oxygen carriers) to prevent their interference in laboratory tests

scientific article published on 01 February 2003

Primary and secondary immune responses to keyhole limpet hemocyanin in rats after infusion of hemoglobin vesicle, an artificial oxygen carrier.

scientific article published on 22 August 2013

Prolonged functional life span of artificial red cells in blood circulation by repeated methylene blue injections

scientific article published on 01 December 2019

Prolonged oxygen-carrying ability of hemoglobin vesicles by coencapsulation of catalase in vivo

scientific article published in November 2003

Purification of concentrated hemoglobin using organic solvent and heat treatment

scientific article published on 01 December 1993

Red blood cells donate electrons to methylene blue mediated chemical reduction of methemoglobin compartmentalized in liposomes in blood.

scientific article published on 11 June 2014

Reduction of methemoglobin via electron transfer from photoreduced flavin: restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles

scientific article published in September 2004

Removal of cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) from blood using centrifugation and ultrafiltration

scientific article published in April 2011

Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model

scientific article published on 01 December 2010

Rheological properties of hemoglobin vesicles (artificial oxygen carriers) suspended in a series of plasma-substitute solutions

scientific article published on 13 June 2007

Ring-Opening Polymerization of Hemoglobin

scientific article published on 15 February 2019

Sodium hydroxide based non-detergent decellularizing solution for rat lung

scientific article published on 11 June 2018

Study on the Phase Transition Behavior of Polymerized Liposomes through the Interaction of Diene-Groups in Their Acyl Chains

Subcutaneous microvascular responses to hemodilution with a red cell substitute consisting of polyethyleneglycol-modified vesicles encapsulating hemoglobin.

scientific article

Surface modification of hemoglobin vesicles with poly(ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90% exchange transfusion in anesthetized rats

scientific article published on 01 January 1997

Swine hemoglobin as a potential source of artificial oxygen carriers, hemoglobin-vesicles.

scientific article published on 19 September 2012

Synthesis and physicochemical characterization of a series of hemoglobin-based oxygen carriers: objective comparison between cellular and acellular types

scientific article published on 01 January 2000

The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders.

scientific article

The oxygen carrying capability of hemoglobin vesicles evaluated in rat exchange transfusion models

scientific article published on 01 July 1997

The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection

scientific article published on 24 July 2008

Transmembrane Difference in Colloid Osmotic Pressure Affects the Lipid Membrane Fluidity of Liposomes Encapsulating a Concentrated Protein Solution

scientific article published on 20 January 2017

Virus inactivation in hemoglobin solution by heat treatment ⬇️

scientific article published on September 1, 2001

What is the major mechanism of slower NO uptake by red blood cells?

scientific article published on October 2011

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