List of works - Caroline Dean

2020 Vision for Biology: The Role of Plants in Addressing Grand Challenges in Biology

article

A PHD-polycomb repressive complex 2 triggers the epigenetic silencing of FLC during vernalization

scholarly article

A Polycomb-based switch underlying quantitative epigenetic memory

scientific article

A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization

scientific article published on 7 December 2012

A method for detecting single mRNA molecules in Arabidopsis thaliana

scientific article published on 05 August 2016

A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome

scientific article published on 25 April 2006

A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates

scientific article published on 24 September 2003

A resource of mapped dissociation launch pads for targeted insertional mutagenesis in the Arabidopsis genome.

scientific article published on 15 May 2003

ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation

scientific article published on 28 March 2008

Absence of warmth permits epigenetic memory of winter in Arabidopsis.

scientific article published on 12 February 2018

Additional targets of the Arabidopsis autonomous pathway members, FCA and FY.

scientific article

Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing

scholarly article

An Arabidopsis example of association mapping in structured samples

scientific article

An allelic series reveals essential roles for FY in plant development in addition to flowering-time control

scientific article

An interview with Caroline Dean

scientific article published in August 2015

Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.

scientific article published on 22 May 2003

Antagonistic roles for H3K36me3 and H3K27me3 in the cold-induced epigenetic switch at Arabidopsis FLC.

scientific article published on 24 July 2014

Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization

scientific article

Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor

scientific article

Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes

scientific article published on 01 May 2019

Arabidopsis transcriptional repressor VAL1 triggers Polycomb silencing at FLC during vernalization

scientific article published on July 2016

Arabidopsis, the Rosetta stone of flowering time?

scientific article

Autonomous Pathway: FLOWERING LOCUS C Repression through an Antisense-Mediated Chromatin-Silencing Mechanism

scientific article published on 18 November 2019

Autoregulation of FCA pre-mRNA processing controls Arabidopsis flowering time

scientific article

Behaviour of the maize transposable element Ac in Arabidopsis thaliana

scientific article published in 1992

COOLAIR Antisense RNAs Form Evolutionarily Conserved Elaborate Secondary Structures.

scientific article published in September 2016

Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-coding RNA COOLAIR Explain Cell-to-Cell Expression Variation.

scientific article published on 8 June 2017

Climate change and the integrity of science

scientific article

Cold-induced Arabidopsis FRIGIDA nuclear condensates for FLC repression

scientific article published on 03 November 2021

Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target

scientific article published in December 2009

Comparative transcriptomics reveals desynchronisation of gene expression during the floral transition between Arabidopsis and Brassica rapa cultivars

scientific article published in 2021

Control of Arabidopsis flowering: the chill before the bloom

scientific article

Cotranscriptional role for Arabidopsis DICER-LIKE 4 in transcription termination

scientific article published in March 2012

Detecting histone modifications in plants

scientific article published in January 2014

Development, evolution and adaptation

article

Differential interactions of the autonomous pathway RRM proteins and chromatin regulators in the silencing of Arabidopsis targets

scientific article

Distinct phases of Polycomb silencing to hold epigenetic memory of cold in Arabidopsis.

scientific article published on 17 August 2017

Divergent perspectives on GM food

scientific article published on 01 December 2002

Environmental perception and epigenetic memory: mechanistic insight through FLC.

scientific article published on 29 May 2015

Epigenetic regulation in plant responses to the environment

scientific article

Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state

scientific article

Expression of bacterial chitinase protein in tobacco leaves using two photosynthetic gene promoters

article

FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex

scientific article published on 8 May 2009

FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition

scientific article published in June 2003

Fine-tuning timing: natural variation informs the mechanistic basis of the switch to flowering in Arabidopsis thaliana

scientific article published on 8 August 2017

Flowering Locus C's Lessons: Conserved Chromatin Switches Underpinning Developmental Timing and Adaptation

scientific article published on 06 July 2015

Flowering time control: another window to the connection between antisense RNA and chromatin.

scientific article published on 10 July 2012

Functional alleles of the flowering time regulator FRIGIDA in the Brassica oleracea genome.

scientific article

Functional consequences of splicing of the antisense transcript COOLAIR on FLC transcription

scientific article published on April 2014

Functional significance of the alternative transcript processing of the Arabidopsis floral promoter FCA.

scientific article

Genome-wide association mapping in Arabidopsis identifies previously known flowering time and pathogen resistance genes

scientific article

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.

scientific article

Growth and development: a broad view of fine detail

scientific article published on 26 December 2008

How Cool Is That: An Interview with Caroline Dean ⬇️

scientific article published on June 27, 2013

Investigations of genome expression in young wheat leaves

doctoral thesis

LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC

scholarly article

Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance.

scientific article published on 8 May 2015

Long non-coding RNAs and chromatin regulation

scientific article published on 17 December 2010

Major-effect alleles at relatively few loci underlie distinct vernalization and flowering variation in Arabidopsis accessions

scientific article (publication date: 2011)

Multiple FLC haplotypes defined by independent cis-regulatory variation underpin life history diversity in Arabidopsis thaliana

scientific article

Multiple pathways in the decision to flower: enabling, promoting, and resetting

scientific article

Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control

scientific article published in July 2002

Mutually exclusive sense-antisense transcription at FLC facilitates environmentally induced gene repression

scientific article published on 7 October 2016

Natural temperature fluctuations promote COOLAIR regulation of FLC

scientific article published on 13 May 2021

Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes

scientific article published on 09 September 2020

Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA.

scientific article published on 12 November 2010

Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory at Arabidopsis FLC

scientific article published on 30 January 2020

Nuclear organization changes and the epigenetic silencing of FLC during vernalization

scientific article published on 30 August 2014

Nucleotide polymorphism affecting FLC expression underpins heading date variation in horticultural brassicas.

scientific article

Phenotypic characterization and molecular mapping of the Arabidopsis thaliana locus RPP5, determining disease resistance to Peronospora parasitica

scientific article published in 1993

Phenotypic evolution through variation in splicing of the noncoding RNA COOLAIR.

scientific article

Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization

scientific article published on September 2013

Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC.

scientific article published on August 2016

Plant genetic effects on microbial hubs impact fitness across field trials

preprint

Plant sciences. Deciding when to flower

scientific article published in December 2003

Protocol: A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis

scientific article published on 13 March 2011

Publisher Correction: Temperature-dependent growth contributes to long-term cold sensing

scientific article published on 25 August 2020

QTL-seq identifies BnaFT.A02 and BnaFLC.A02 as candidates for variation in vernalisation requirement and response in winter oilseed rape (Brassica napus)

scientific article published on 26 May 2020

Quantitative Modulation of Polycomb Silencing Underlies Natural Variation in Vernalization

scientific article published in Science

Quantitative regulation of FLC via coordinated transcriptional initiation and elongation

scientific article

R-loop resolution promotes co-transcriptional chromatin silencing

scientific article published on 19 March 2021

R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus.

scientific article published on May 2013

RNA 3' processing functions of Arabidopsis FCA and FPA limit intergenic transcription

scientific article

RNA Binding Proteins RZ-1B and RZ-1C Play Critical Roles in Regulating Pre-mRNA Splicing and Gene Expression during Development in Arabidopsis.

scientific article published on 31 December 2015

Recombinant inbred lines for mapping RFLP and phenotypic markers in Arabidopsis thaliana

scientific article published in 1993

Regulated RNA processing in the control of Arabidopsis flowering

scientific article

Regulation of the floral repressor gene FLC: the complexity of transcription in a chromatin context

scientific article published on 29 September 2010

Remembering the prolonged cold of winter

scientific article published on September 2013

Resetting and regulation of Flowering Locus C expression during Arabidopsis reproductive development

scientific article published on 17 January 2009

Resetting of FLOWERING LOCUS C expression after epigenetic repression by vernalization

scholarly article

Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis

scientific article published on 20 May 2005

Seasonal shift in timing of vernalization as an adaptation to extreme winter.

scientific article

Single Molecule RNA FISH in Arabidopsis Root Cells

article

Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity

scientific article published on 21 March 2017

Small RNA-mediated chromatin silencing directed to the 3' region of the Arabidopsis gene encoding the developmental regulator, FLC.

scholarly article

Storing memories: the distinct phases of Polycomb-mediated silencing of Arabidopsis FLC

scientific article published on 05 July 2019

Targeted 3' processing of antisense transcripts triggers Arabidopsis FLC chromatin silencing

scientific article

Temperature Sensing Is Distributed throughout the Regulatory Network that Controls FLC Epigenetic Silencing in Vernalization

scientific article published on 28 November 2018

Temperature-dependent growth contributes to long-term cold sensing

scientific article published on 15 July 2020

The 3' processing of antisense RNAs physically links to chromatin-based transcriptional control

scientific article published on 15 June 2020

The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC.

scientific article published in November 2007

The Arabidopsis epigenetic regulator ICU11 as an accessory protein of Polycomb Repressive Complex 2

scientific article published on 29 June 2020

The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation

scientific article

The PHD finger protein VRN5 functions in the epigenetic silencing of Arabidopsis FLC.

scientific article published on 14 December 2006

The molecular basis of photoperiodism

scientific article

The need for winter in the switch to flowering

scientific article published on January 2003

The timing of developmental transitions in plants

scientific article

Transcription beyond borders has downstream consequences ⬇️

scientific article published on February 1, 2012

Transgenic plants protected from insect attack

scientific article (publication date: 2 July 1987)

Variation in the epigenetic silencing of FLC contributes to natural variation in Arabidopsis vernalization response

scientific article published on November 2006

Vernalization - a cold-induced epigenetic switch

scientific article published on 30 August 2012

Vernalization requires epigenetic silencing of FLC by histone methylation

scientific article

Vernalizing cold is registered digitally at FLC

scientific article

What holds epigenetic memory?

scientific article published in February 2017

Widespread role for the flowering-time regulators FCA and FPA in RNA-mediated chromatin silencing

scientific article

Women in Science

scientific article

List of works by Caroline Dean

2020 Vision for Biology: The Role of Plants in Addressing Grand Challenges in Biology

A PHD-polycomb repressive complex 2 triggers the epigenetic silencing of FLC during vernalization

A Polycomb-based switch underlying quantitative epigenetic memory

A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization

A method for detecting single mRNA molecules in Arabidopsis thaliana

A nonparametric test reveals selection for rapid flowering in the Arabidopsis genome

A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates

A resource of mapped dissociation launch pads for targeted insertional mutagenesis in the Arabidopsis genome.

ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation

Absence of warmth permits epigenetic memory of winter in Arabidopsis.

Additional targets of the Arabidopsis autonomous pathway members, FCA and FY.

Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing

An Arabidopsis example of association mapping in structured samples

An allelic series reveals essential roles for FY in plant development in addition to flowering-time control

An interview with Caroline Dean

Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.

Antagonistic roles for H3K36me3 and H3K27me3 in the cold-induced epigenetic switch at Arabidopsis FLC.

Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization

Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor

Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes

Arabidopsis transcriptional repressor VAL1 triggers Polycomb silencing at FLC during vernalization

Arabidopsis, the Rosetta stone of flowering time?

Autonomous Pathway: FLOWERING LOCUS C Repression through an Antisense-Mediated Chromatin-Silencing Mechanism

Autoregulation of FCA pre-mRNA processing controls Arabidopsis flowering time

Behaviour of the maize transposable element Ac in Arabidopsis thaliana

COOLAIR Antisense RNAs Form Evolutionarily Conserved Elaborate Secondary Structures.

Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-coding RNA COOLAIR Explain Cell-to-Cell Expression Variation.

Climate change and the integrity of science

Cold-induced Arabidopsis FRIGIDA nuclear condensates for FLC repression

Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target

Comparative transcriptomics reveals desynchronisation of gene expression during the floral transition between Arabidopsis and <i>Brassica rapa</i> cultivars

Control of Arabidopsis flowering: the chill before the bloom

Cotranscriptional role for Arabidopsis DICER-LIKE 4 in transcription termination

Detecting histone modifications in plants

Development, evolution and adaptation

Differential interactions of the autonomous pathway RRM proteins and chromatin regulators in the silencing of Arabidopsis targets

Distinct phases of Polycomb silencing to hold epigenetic memory of cold in Arabidopsis.

Divergent perspectives on GM food

Environmental perception and epigenetic memory: mechanistic insight through FLC.

Epigenetic regulation in plant responses to the environment

Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state

Expression of bacterial chitinase protein in tobacco leaves using two photosynthetic gene promoters

FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex

FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition

Fine-tuning timing: natural variation informs the mechanistic basis of the switch to flowering in Arabidopsis thaliana

Flowering Locus C's Lessons: Conserved Chromatin Switches Underpinning Developmental Timing and Adaptation

Flowering time control: another window to the connection between antisense RNA and chromatin.

Functional alleles of the flowering time regulator FRIGIDA in the Brassica oleracea genome.

Functional consequences of splicing of the antisense transcript COOLAIR on FLC transcription

Functional significance of the alternative transcript processing of the Arabidopsis floral promoter FCA.

Genome-wide association mapping in Arabidopsis identifies previously known flowering time and pathogen resistance genes

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.

Growth and development: a broad view of fine detail

How Cool Is That: An Interview with Caroline Dean ⬇️

Investigations of genome expression in young wheat leaves

LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC

Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance.

Long non-coding RNAs and chromatin regulation

Major-effect alleles at relatively few loci underlie distinct vernalization and flowering variation in Arabidopsis accessions

Multiple FLC haplotypes defined by independent cis-regulatory variation underpin life history diversity in Arabidopsis thaliana

Multiple pathways in the decision to flower: enabling, promoting, and resetting

Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control

Mutually exclusive sense-antisense transcription at FLC facilitates environmentally induced gene repression

Natural temperature fluctuations promote <i>COOLAIR</i> regulation of <i>FLC</i>

Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes

Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA.

Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory at Arabidopsis FLC

Nuclear organization changes and the epigenetic silencing of FLC during vernalization

Nucleotide polymorphism affecting FLC expression underpins heading date variation in horticultural brassicas.

Phenotypic characterization and molecular mapping of the Arabidopsis thaliana locus RPP5, determining disease resistance to Peronospora parasitica

Phenotypic evolution through variation in splicing of the noncoding RNA COOLAIR.

Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization

Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC.

Plant genetic effects on microbial hubs impact fitness across field trials

Plant sciences. Deciding when to flower

Protocol: A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis

Publisher Correction: Temperature-dependent growth contributes to long-term cold sensing

QTL-seq identifies BnaFT.A02 and BnaFLC.A02 as candidates for variation in vernalisation requirement and response in winter oilseed rape (Brassica napus)

Quantitative Modulation of Polycomb Silencing Underlies Natural Variation in Vernalization