List of works - Michela Rugolo

'Behr syndrome' with OPA1 compound heterozygote mutations

scientific article published on 21 August 2014

7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells

scientific article

A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.

scientific article published on 24 February 2011

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.

scientific article

A novel in-frame 18-bp microdeletion in MT-CYB causes a multisystem disorder with prominent exercise intolerance

scientific article published on 28 June 2014

A volume-sensitive chloride conductance revealed in cultured human keratinocytes by 36Cl- efflux and whole-cell patch clamp recording

scientific article published on 01 November 1992

Activation of Ca(2+)-dependent K+ and Cl- currents by UTP and ATP in CFPAC-1 cells

scientific article published on 01 April 1994

An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells

scientific article

Apoptotic cell death of cybrid cells bearing Leber's hereditary optic neuropathy mutations is caspase independent

scientific article published in December 2003

Arachidonic acid release by ionomycin and phorbol ester is similar in C127 epithelial cells expressing wild-type or mutated (delta F508) cystic fibrosis transmembrane conductance regulator

scientific article published on October 1999

Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration

scientific article published in July 2004

Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G.

scientific article

Changes in membrane permeability in cells infected by human cytomegalovirus

scientific article published in January 1986

Characterization of chloride transport pathways in cultured human keratinocytes.

scientific article

Chloride transport in human fibroblasts is activated by hypotonic shock

scientific article

Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

scientific article published on June 2006

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment

scientific article published on 24 October 2013

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

scholarly article

Efflux of magnesium and potassium ions from liver mitochondria induced by inorganic phosphate and by diamide

scientific article published on April 1978

Extracellular 2-chloroadenosine and ATP stimulate volume-sensitive Cl- current and calcium mobilization in human tracheal 9HTEo- cells

scientific article

Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.

scientific article published on 13 June 2013

Glucose transport activation in human hematopoietic cells M07e is modulated by cytosolic calcium and calmodulin

scientific article published on 9 June 2006

Green tea modulates alpha(1)-adrenergic stimulated glucose transport in cultured rat cardiomyocytes

scientific article published on 4 August 2007

Hypotonic shock activated Cl- and K+ pathways in human fibroblasts

scientific article published on 01 November 1991

Increased chloride efflux in fibroblasts from X-linked muscular dystrophies and clones from Duchenne carriers.

scientific article published in February 1987

Inhibition of the mitochondrial bc1 complex by dibromothymoquinone

scientific article published on May 1983

Involvement of endogenous phospholipase A2 in Ca2+ and Mg2+ movement induced by inorganic phosphate and diamide in rat liver mitochondria

scientific article published on May 1979

Kinetic alterations of cytochrome-c oxidase in cystic fibrosis

scientific article published on 01 April 1986

Kinetic analysis of chloride efflux from normal and cystic fibrosis fibroblasts.

scientific article published in January 1986

Learning from oncocytic tumors: Why choose inefficient mitochondria?

scientific article published on 21 August 2010

Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium

scientific article

Mitochondria: Biogenesis and mitophagy balance in segregation and clonal expansion of mitochondrial DNA mutations.

scientific article published on 07 February 2015

Monitoring of the mitochondrial and plasma membrane potentials in human fibroblasts by tetraphenylphosphonium ion distribution

scientific article published on 01 December 1987

OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion

scientific article published in February 2008

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

scientific article

Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism

scientific article published on August 1997

Phosphate transport in mitochondria and submitochondrial particles: the influence of thiol oxidation

scientific article published in June 1977

Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells

scientific article

Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta

scientific article

Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids

scientific article

Rare mtDNA variants in Leber hereditary optic neuropathy families with recurrence of myoclonus.

scientific article published on 23 January 2008

Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels

scientific article

Role of CFTR and anion exchanger in bicarbonate fluxes in C127 cell lines.

scientific article published on December 1998

Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor

scientific article (publication date: March 2000)

Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells

scientific article published on November 1996

Staurosporine induces apoptotic volume decrease (AVD) in ECV304 cells.

scientific article published on December 2003

Studies on the transport of carnitine in the brain using synaptosomes isolated from guinea-pig cerebral cortex.

scientific article published in October 1983

Syndromic parkinsonism and dementia associated with OPA1 missense mutations

scientific article

Synergic action of calcium ions and diamide on mitochondrial swelling

scientific article published in October 1975

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

scientific article

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity

scientific article

The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes

scientific article published on 14 February 2013

The effects of idebenone on mitochondrial bioenergetics ⬇️

scientific article

The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization

scientific article published on 22 December 2009

The phorbol ester PMA and cyclic AMP activate different Cl(-) and HCO3(-) fluxes in C127 cells expressing CFTR.

scientific article published on February 2001

The response of chloride transport to cyclic AMP, calcium and hypotonic shock in normal and cystic fibrosis fibroblasts

scientific article published on January 1990

Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux

scientific article published on 01 October 1993

Why mitochondria must fuse to maintain their genome integrity

scientific article

pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant

scientific article

List of works by Michela Rugolo

'Behr syndrome' with OPA1 compound heterozygote mutations

7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells

A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.

A novel in-frame 18-bp microdeletion in MT-CYB causes a multisystem disorder with prominent exercise intolerance

A volume-sensitive chloride conductance revealed in cultured human keratinocytes by 36Cl- efflux and whole-cell patch clamp recording

Activation of Ca(2+)-dependent K+ and Cl- currents by UTP and ATP in CFPAC-1 cells

An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells

Apoptotic cell death of cybrid cells bearing Leber's hereditary optic neuropathy mutations is caspase independent

Arachidonic acid release by ionomycin and phorbol ester is similar in C127 epithelial cells expressing wild-type or mutated (delta F508) cystic fibrosis transmembrane conductance regulator

Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration

Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G.

Changes in membrane permeability in cells infected by human cytomegalovirus

Characterization of chloride transport pathways in cultured human keratinocytes.

Chloride transport in human fibroblasts is activated by hypotonic shock

Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

Efflux of magnesium and potassium ions from liver mitochondria induced by inorganic phosphate and by diamide

Extracellular 2-chloroadenosine and ATP stimulate volume-sensitive Cl- current and calcium mobilization in human tracheal 9HTEo- cells

Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.

Glucose transport activation in human hematopoietic cells M07e is modulated by cytosolic calcium and calmodulin

Green tea modulates alpha(1)-adrenergic stimulated glucose transport in cultured rat cardiomyocytes

Hypotonic shock activated Cl- and K+ pathways in human fibroblasts

Increased chloride efflux in fibroblasts from X-linked muscular dystrophies and clones from Duchenne carriers.

Inhibition of the mitochondrial bc1 complex by dibromothymoquinone

Involvement of endogenous phospholipase A2 in Ca2+ and Mg2+ movement induced by inorganic phosphate and diamide in rat liver mitochondria

Kinetic alterations of cytochrome-c oxidase in cystic fibrosis

Kinetic analysis of chloride efflux from normal and cystic fibrosis fibroblasts.

Learning from oncocytic tumors: Why choose inefficient mitochondria?

Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium

Mitochondria: Biogenesis and mitophagy balance in segregation and clonal expansion of mitochondrial DNA mutations.

Monitoring of the mitochondrial and plasma membrane potentials in human fibroblasts by tetraphenylphosphonium ion distribution

OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism

Phosphate transport in mitochondria and submitochondrial particles: the influence of thiol oxidation

Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells

Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta

Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids

Rare mtDNA variants in Leber hereditary optic neuropathy families with recurrence of myoclonus.

Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels

Role of CFTR and anion exchanger in bicarbonate fluxes in C127 cell lines.

Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor

Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells

Staurosporine induces apoptotic volume decrease (AVD) in ECV304 cells.

Studies on the transport of carnitine in the brain using synaptosomes isolated from guinea-pig cerebral cortex.

Syndromic parkinsonism and dementia associated with OPA1 missense mutations

Synergic action of calcium ions and diamide on mitochondrial swelling

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity

The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes

The effects of idebenone on mitochondrial bioenergetics ⬇️

The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization

The phorbol ester PMA and cyclic AMP activate different Cl(-) and HCO3(-) fluxes in C127 cells expressing CFTR.

The response of chloride transport to cyclic AMP, calcium and hypotonic shock in normal and cystic fibrosis fibroblasts

Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux

Why mitochondria must fuse to maintain their genome integrity

pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant