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List of works by Cesare Montecucco

A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage

scientific article published on 14 November 2019

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.

scientific article

A lysolecithin/fatty acid mixture promotes and then blocks neurotransmitter release at the Drosophila melanogaster larval neuromuscular junction

scientific article published on 25 January 2007

A molecular model of the Vibrio cholerae cytolysin transmembrane pore

scientific article

ATP Released by Injured Neurons Activates Schwann Cells

scientific article published on 23 May 2016

An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals

scientific article published on 30 September 2019

An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells

scientific article published on 2 September 2016

An update on the mechanism of action of tetanus and botulinum neurotoxins.

scientific article

Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells

scientific article published in April 2005

Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.

scientific article

Anthrax toxin: a tripartite lethal combination

scientific article

Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling

scientific article published on 03 November 2006

Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling

scientific article

Anthrax toxins: A paradigm of bacterial immune suppression

scientific article published on 24 July 2006

Antiepileptic effects of botulinum neurotoxin E.

scientific article

Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction

scientific article published on 7 September 2010

Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg

scientific article published on 01 September 2009

Bacillus anthracis: balancing innocent research with dual-use potential

scientific article published on 28 March 2008

Bontoxilysins

Bontoxilysins

Borrelia burgdorferiNapA-driven Th17 cell inflammation in lyme arthritis

scientific article published on 01 November 2008

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

scientific article

Botulinal neurotoxins: revival of an old killer

scientific article (publication date: June 2005)

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

scientific article published on April 2017

Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study.

scientific article published on 13 December 2012

Botulinum neurotoxin serotypes A and C do not affect motor units survival in humans: an electrophysiological study by motor units counting.

scientific article published in August 2002

Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction.

scientific article

Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in mice

scientific article published on 9 March 2006

Botulinum neurotoxins are metalloproteases specific for SNARE proteins involved in neuroexocytosis

scientific article

Botulinum neurotoxins: genetic, structural and mechanistic insights.

scientific article published on 30 June 2014

CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals.

scientific article published on 30 May 2017

Calcium Influx and Mitochondrial Alterations at Synapses Exposed to Snake Neurotoxins or Their Phospholipid Hydrolysis Products

scientific article published on 20 February 2007

Calcium overload in nerve terminals of cultured neurons intoxicated by alpha-latrotoxin and snake PLA2 neurotoxins

scientific article published on 31 March 2009

Calpains participate in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins.

scientific article published on 22 December 2012

Cell entry and cAMP imaging of anthrax edema toxin

scientific article published on 2 November 2006

Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori

scientific article published on November 2002

Clinical duration of action of different botulinum toxin types in humans

scientific article published on 14 March 2020

Correction: Anthrax Edema Toxin Modulates PKA- and CREB-Dependent Signaling in Two Phases.

scientific article published on 5 November 2008

Crystal structure of antigen TpF1 from Treponema pallidum

scientific article

Current gaps in basic science knowledge of botulinum neurotoxin biological actions.

scientific article

Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls.

scientific article

Different mechanisms of inhibition of nerve terminals by botulinum and snake presynaptic neurotoxins

scientific article published on 14 December 2008

Different types of botulinum toxin in humans

scientific article published in March 2004

Diphtheria toxin conformational switching at acidic pH

scientific article

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

scientific article

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin

scientific article published on April 2016

Editorial

scientific article published on 4 September 2009

Electric dipole reorientation in the interaction of botulinum neurotoxins with neuronal membranes

scientific article published on 02 July 2009

Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom. ⬇️

scientific article published on 27 February 2017

Entering neurons: botulinum toxins and synaptic vesicle recycling

scientific article published on October 2006

Envenomations by Bothrops and Crotalus snakes induce the release of mitochondrial alarmins

scientific article

Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures

scientific article

Erratum to "Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism" [Biochem. Pharmacol. 98 (2015) 522-530].

scientific article published on 12 July 2016

Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.

scientific article published on 17 May 2013

Glycogen synthase kinase 3 activation is essential for the snake phospholipase A2 neurotoxin-induced secretion in chromaffin cells

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

scientific article published on 19 December 2017

Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals

scientific article published on 27 October 2017

Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.

scientific article

Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells.

scientific article

Identification and characterization of Clostridium botulinum group III field strains by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS).

scientific article published on 9 August 2017

Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras

scientific article published in October 2010

Immunosuppressive and proinflammatory activities of the VacA toxin of Helicobacter pylori

scientific article published on December 2003

Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism.

scientific article published on 5 October 2015

Internalization and mechanism of action of clostridial toxins in neurons

scientific article

Ion channel and membrane translocation of diphtheria toxin

scientific article

Lysophospholipids are evolutionary ancient venom components

scientific article published on 6 July 2010

Mass spectrometry analysis of the phospholipase A(2) activity of snake pre-synaptic neurotoxins in cultured neurons.

scientific article published on 27 August 2009

Membrane Protein Labelling with Photoreactive Phospholipid Analogues

Mitochondrial alarmins released by degenerating motor axon terminals activate perisynaptic Schwann cells

scientific article

Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori

scientific article

Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A₂ myotoxins--distinct mechanisms of action

scientific article published on 12 July 2013

Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C

scientific article published on 01 May 2007

Neurotoxicity of inverted-cone shaped lipids

scientific article

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

scientific article published on 21 October 2013

On the Cellular Mechanism of Action of Diphtheria Toxin

On the quaternary structure of taipoxin and textilotoxin: the advantage of being multiple.

scientific article

On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments.

scientific article published on 22 August 2015

Paralytic activity of lysophosphatidylcholine from saliva of the waterbug Belostoma anurum

scientific article published in October 2010

Phosphorylation of VAMP/synaptobrevin in synaptic vesicles

Potent inhibitors of anthrax lethal factor from green tea

scientific article

Presynaptic enzymatic neurotoxins.

scientific article

Presynaptic receptor arrays for clostridial neurotoxins.

scientific article published in October 2004

Primary resistance of human patients to botulinum neurotoxins A and B.

scientific article

Proteases

Ratio of lethal and edema factors in rabbit systemic anthrax

scientific article published on 5 September 2008

Recombinant and Truncated Tetanus Neurotoxin Light Chain: Cloning, Expression, Purification, and Proteolytic Activity

Reversible skeletal neuromuscular paralysis induced by different lysophospholipids

scientific article published on 26 October 2006

SNARE complexes and neuroexocytosis: how many, how close?

scientific article

Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome

scientific article

Screening inhibitors of anthrax lethal factor

scientific article published on July 2002

Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication.

scientific article

Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction

scientific article

Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores.

scientific article published on 22 September 2008

Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles

scientific article

Stop the killer: how to inhibit the anthrax lethal factor metalloprotease

scientific article published on 01 June 2004

Streptococcus pneumoniae induces mast cell degranulation

scientific article published on 10 March 2006

Structural Studies on the Zinc-endopeptidase Light Chain of Tetanus Neurotoxin

scientific article published in 1995

Structure of the neutrophil-activating protein from Helicobacter pylori

scientific article

Structure of two iron-binding proteins from Bacillus anthracis

scientific article

Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis

scientific article

Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo

scientific article

Tables of Toxicity of Botulinum and Tetanus Neurotoxins

scientific article published on 22 November 2019

Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells

scientific article published on 01 April 2003

Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2.

scientific article

Tetanus toxin blocks the exocytosis of synaptic vesicles clustered at synapses but not of synaptic vesicles in isolated axons

scientific article published on August 1999

The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes

scientific article published on 14 October 2009

The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations.

scientific article published on February 2005

The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane

scientific article published on 20 January 2009

The Neurospecific Binding of Tetanus Toxin is Mediated by a 20 kDa Protein and by Acidic Lipids

The Neutrophil-Activating Protein of Helicobacter pylori Crosses Endothelia to Promote Neutrophil Adhesion In Vivo

scientific article published on 01 February 2007

The Structure and Mode of Action of Botulinum and Tetanus Toxins

The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production

scientific article published on 15 November 2007

The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death

scientific article published on July 2002

The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling

scientific article

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

scientific article published on 09 December 2013

The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity

scientific article published on 07 August 2009

The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65

scientific article

The blockade of the neurotransmitter release apparatus by botulinum neurotoxins

scientific article published on 11 June 2013

The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes

scientific article published on 23 January 2007

The crystal structure of CagS from theHelicobacter pyloripathogenicity island

scientific article published on 01 November 2007

The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain

scientific article published on 22 July 2016

The mechanism of action of tetanus and botulinum neurotoxins

scientific article published on January 1996

The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited.

scientific article published on 29 July 2003

The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori

scientific article published on April 2004

The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells

scientific article published in March 2002

The neutrophil-activating protein of Helicobacter pylori

scientific article

The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils

scientific article published on 01 April 2003

The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs

scientific article published on 23 May 2019

The synaptotagmin juxtamembrane domain is involved in neuroexocytosis.

scientific article published on 30 April 2015

The thioredoxin reductase--Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles.

scientific article published on 27 June 2015

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.

scientific article

Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

scientific article

Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication

scientific article published on 24 April 2015

Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons ⬇️

scientific article published on November 27, 2012

Toxicity of botulinum neurotoxins in central nervous system of mice

scientific article published in March 2003

Traffic of botulinum toxins A and E in excitatory and inhibitory neurons.

scientific article

Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity

scientific article

Tyrosine-728 and glutamic acid-735 are essential for the metalloproteolytic activity of the lethal factor of Bacillus anthracis.

scientific article published in January 2004

VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes

scientific article published on 01 May 2003

VacA and HP-NAP, Ying and Yang of Helicobacter pylori-associated gastric inflammation.

scientific article published on 21 February 2007

Where and how do anthrax toxins exit endosomes to intoxicate host cells?

scientific article published on 5 November 2007

Why myotoxin-containing snake venoms possess powerful nucleotidases?

scientific article published on 19 December 2012

cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin

scientific article published on 13 September 2008

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