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List of works by Mark F van Delft

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

scientific article

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

scientific article published on 07 October 2019

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

scientific article

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases.

scientific article

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

scientific article

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

scientific article published in December 2014

Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

scientific article published on 28 November 2005

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

scientific article published in February 2018

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

scientific article published on 17 January 2018

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

scientific article

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

scientific article published in November 2017

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

scientific article published on 26 June 2013

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

scientific article published on 20 December 2013

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.

scientific article published on 14 January 2016

How the Bcl-2 family of proteins interact to regulate apoptosis.

scientific article

MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex

scientific article published on 24 February 2020

RNA association and nucleocytoplasmic shuttling by ataxin-1

scientific article

SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress

scientific article published on 6 February 2017

Structural insights into the degradation of Mcl-1 induced by BH3 domains

scientific article

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

scientific article published in January 2005

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

scientific article published on November 2006

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

scientific article

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

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