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List of works by Kumlesh K. Dev

A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.

scientific article published on 26 February 2018

Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice

scientific article published on June 2007

Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning.

scientific article published on 9 August 2007

Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis

scientific article published on 08 September 2007

Characterisation of the interaction between guanyl nucleotides and AMPA receptors in rat brain

scientific article published on 01 January 1996

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

scientific article

Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors.

scientific article published on 4 April 2017

Design and synthesis of selective and potent orally active S1P5 agonists.

scientific article published on October 2010

Different effects of phospholipase A2 on agonist binding to hippocampal, cortical and recombinant homomeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors.

scientific article published on April 1998

Drug dealers: $20 trillion of in-licensing payments.

scientific article published on 22 August 2013

EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination

scientific article published on 16 December 2017

EBI2 regulates intracellular signaling and migration in human astrocyte

scientific journal article

Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease

scientific article published on 03 March 2020

Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures

scientific article

Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes.

scientific article published on 22 August 2016

Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines.

scientific article published on 31 August 2004

GABA(B) receptors couple directly to the transcription factor ATF4.

scientific article published on April 2001

Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling.

scientific article published on 10 September 2015

High-affinity binding sites for 125I-labelled pancreatic secretory phospholipase A2 in rat brain.

scientific article published in October 1997

Identification of novel genes and pathways regulating SREBP transcriptional activity

scientific article

In vitro and ex vivo models of multiple sclerosis.

scientific article published on 2 June 2016

Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.

scientific article

Increased interleukin 23 (IL23) levels in schizophrenia patients treated with depot antipsychotic medication

scientific article

Inhibition of Piezo1 attenuates demyelination in the central nervous system

scientific article published on 09 October 2019

Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation.

scientific article published on 14 February 2008

Levels of S100B are raised in female patients with schizophrenia.

scientific article

Lipid sensing G protein-coupled receptors in the CNS.

scientific article published in February 2017

Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

scientific journal article

Neuropathology in mice expressing mouse alpha-synuclein

scientific article (publication date: 2011)

PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.

scientific article

Part I: parkin-associated proteins and Parkinson's disease.

scientific article

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

scientific article

Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination.

scientific article

Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.

scientific article published on 26 March 2007

Piezo1 regulates calcium oscillations and cytokine release from astrocytes

scientific article published on 21 August 2019

Pro-inflammatory cytokine levels are raised in female schizophrenia patients treated with clozapine.

scientific article published on 16 April 2014

Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP

scientific article

Regulation of glutamate release by presynaptic kainate receptors in the hippocampus

scientific article published in Nature

Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptors.

scientific article published on 14 March 2003

Regulation of synaptic strength and AMPA receptor subunit composition by PICK1

scientific article published on June 2004

S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures

scientific article published on 22 November 2011

Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice.

scientific article published on 27 February 2013

Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases.

scientific article published on 4 November 2016

Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations.

scientific article

The Cellular Protein Level of Parkin Is Regulated by Its Ubiquitin-like Domain

scientific article published in Journal of Biological Chemistry

The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages.

scientific article published on 11 May 2016

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.

scientific article published on 9 July 2004

The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs

scientific article (publication date: 3 May 2002)

The PSD-95/nNOS complex: new drugs for depression?

scientific article

The binding affinities of proteins interacting with the PDZ domain of PICK1.

scientific article published on 24 February 2012

The chemokine fractalkine (CX3CL1) attenuates H2O2-induced demyelination in cerebellar slices

scientific article published on 15 August 2017

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.

scientific article published on 08 February 2016

The expression of neuronal sorting nexin 8 (SNX8) exacerbates abnormal cholesterol levels.

scientific article published on 21 December 2013

The premium of a big pharma license deal

scientific article published on 01 July 2014

The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death

scientific article

The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits

scientific journal article

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

scientific article published on 14 February 2014

The structure and function of the S1P1 receptor

scientific article published on 11 June 2013

The use of cytokine signature patterns: separating drug naïve, interferon and natalizumab-treated multiple sclerosis patients

scientific article published on 30 June 2014

Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies.

scientific article published on January 2006

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