List of works - Olga Meiri Chaim

A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: Cloning, heterologous expression and immunological cross-reactivity approaches ⬇️

scientific article published on June 8, 2013

A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis.

scientific article published on 19 July 2010

A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization.

scientific article

Active site mapping of Loxosceles phospholipases D: Biochemical and biological features

scientific article published on 24 May 2016

Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of the brown spider (Loxosceles intermedia)

scientific article published on 01 May 2009

Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles).

scientific article

Biotechnological applications of brown spider (Loxosceles genus) venom toxins

scientific article

Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics

scientific article published on 19 June 2019

Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity

scientific article

Brown spider (Loxosceles genus) venom toxins: tools for biological purposes

scientific article (publication date: March 2011)

Brown spider dermonecrotic toxin directly induces nephrotoxicity.

scientific article published on 11 July 2005

Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: identification and functional characterization.

scientific article published on November 2013

Characterization of Brown spider (Loxosceles intermedia) hemolymph: cellular and biochemical analyses.

scientific article published on 24 February 2015

Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D fromLoxosceles intermediavenom

scientific article

Cytotoxic, thrombolytic and edematogenic activities of leucurolysin-a, a metalloproteinase from Bothrops leucurus snake venom

scientific article published on 14 March 2007

Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase

scientific article published on 12 January 2011

Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches

scientific article published on 07 September 2013

Effects of the venom and the dermonecrotic toxin LiRecDT1 of Loxosceles intermedia in the rat liver.

scientific article published on 13 August 2008

Experimental evidence for a direct cytotoxicity of Loxosceles intermedia (brown spider) venom in renal tissue

scientific article

Expression and immunological cross-reactivity of LALP3, a novel astacin-like metalloprotease from brown spider (Loxosceles intermedia) venom

scientific article published on 22 June 2016

Highlights in the knowledge of brown spider toxins

scientific article

Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo-beta-N-acetyl-d-hexosaminidases hydrolases.

scientific article

Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase-D (dermonecrotic toxin) from brown spider venom.

scientific article

Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom

scientific article published on 26 November 2007

Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom

scientific article

Inflammatory events induced by brown spider venom and its recombinant dermonecrotic toxin: a pharmacological investigation.

scientific article published on 13 November 2008

Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus.

scientific article published on 15 October 2016

Loxosceles Astacin-Like Proteases (LALPs)

Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom

scientific article published on 24 February 2013

Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (brown spider) venom gland

scientific article published on 23 March 2006

Molecular cloning and in silico characterization of knottin peptide, U2-SCRTX-Lit2, from brown spider (Loxosceles intermedia) venom glands

scientific article published on 3 August 2016

Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom.

scientific article

Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: endothelial cell membrane phospholipids as targets for toxicity

scientific article published on 20 November 2010

Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase-D.

scientific article

Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins

scientific article

Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D

scientific article

Structure of a novel class II phospholipase D: catalytic cleft is modified by a disulphide bridge

scientific article

TCTP as a therapeutic target in melanoma treatment

scientific article published on 27 July 2017

The effect of brown spider venom on endothelial cell morphology and adhesive structures.

scientific article published on 10 March 2006

The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase-D toxin.

scientific article

Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization

scientific article

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

scientific article published on 11 June 2018

List of works by Olga Meiri Chaim

A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: Cloning, heterologous expression and immunological cross-reactivity approaches ⬇️

A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis.

A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization.

Active site mapping of Loxosceles phospholipases D: Biochemical and biological features

Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of the brown spider (Loxosceles intermedia)

Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles).

Biotechnological applications of brown spider (Loxosceles genus) venom toxins

Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics

Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity

Brown spider (Loxosceles genus) venom toxins: tools for biological purposes

Brown spider dermonecrotic toxin directly induces nephrotoxicity.

Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: identification and functional characterization.

Characterization of Brown spider (Loxosceles intermedia) hemolymph: cellular and biochemical analyses.

Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D fromLoxosceles intermediavenom

Cytotoxic, thrombolytic and edematogenic activities of leucurolysin-a, a metalloproteinase from Bothrops leucurus snake venom

Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase

Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches

Effects of the venom and the dermonecrotic toxin LiRecDT1 of Loxosceles intermedia in the rat liver.

Experimental evidence for a direct cytotoxicity of Loxosceles intermedia (brown spider) venom in renal tissue

Expression and immunological cross-reactivity of LALP3, a novel astacin-like metalloprotease from brown spider (Loxosceles intermedia) venom

Highlights in the knowledge of brown spider toxins

Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo-beta-N-acetyl-d-hexosaminidases hydrolases.

Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase-D (dermonecrotic toxin) from brown spider venom.

Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom

Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom

Inflammatory events induced by brown spider venom and its recombinant dermonecrotic toxin: a pharmacological investigation.

Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus.

Loxosceles Astacin-Like Proteases (LALPs)

Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom

Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (brown spider) venom gland

Molecular cloning and in silico characterization of knottin peptide, U2-SCRTX-Lit2, from brown spider (Loxosceles intermedia) venom glands

Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom.

Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: endothelial cell membrane phospholipids as targets for toxicity

Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase-D.

Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins

Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D

Structure of a novel class II phospholipase D: catalytic cleft is modified by a disulphide bridge

TCTP as a therapeutic target in melanoma treatment

The effect of brown spider venom on endothelial cell morphology and adhesive structures.

The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase-D toxin.

Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity