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List of works by Margaret A Knowles

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PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs

scientific article published on March 19, 2012
Bladder cancer subtypes defined by genomic alterations

scientific article published on September 2008
Altered Splicing of FGFR1 Is Associated with High Tumor Grade and Stage and Leads to Increased Sensitivity to FGF1 in Bladder Cancer

scientific article published on October 1, 2010
Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder

scientific article published on December 14, 2001
Expression of Engrailed-2 (EN2) protein in bladder cancer and its potential utility as a urinary diagnostic biomarker

scientific article published on 21 February 2013
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

scientific article published on 26 May 2014
Frequency of TERT Promoter Mutations in Prostate Cancer

scientific article
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study

scientific article published on March 2015
Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma

scientific article published on May 2010
Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.

scientific article
Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor

scientific article
FGFR3 Expression in Primary Invasive Bladder Cancers and Matched Lymph Node Metastases

scientific article published on June 13, 2014
Necdin: a multi functional protein with potential tumor suppressor role?

scientific article published in November 2009
Molecular subtyping of invasive bladder cancer: time to divide and rule?

scientific article published on February 2014
Identification and Characterization of the Human Homologue of SH3BP2, an SH3 Binding Domain Protein within a Common Region of Deletion at 4p16.3 Involved in Bladder Cancer

scientific article published on September 1, 1997
Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligation-dependent probe amplification

scientific article
Human papillomavirus sequences are not detectable by Southern blotting or general primer-mediated polymerase chain reaction in transitional cell tumours of the bladder

scientific article published on January 1, 1992
Tumor suppressor loci in bladder cancer

scientific article published on January 2007
Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant

scientific article
High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma

scientific article
A place for precision medicine in bladder cancer: targeting the FGFRs

scientific article
Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative therapeutic target for a small subgroup

scientific article published on 22 September 2016
Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities

scientific article
Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity

scientific article
Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss.

scientific article published on January 2005
Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3.

scientific article published on 15 September 2014
Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).

scientific article published on August 2009
Assessing the quality of studies on the diagnostic accuracy of tumor markers

scientific article
High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder

scientific article
Towards a Next-Generation Sequencing Diagnostic Service for Tumour Genotyping: A Comparison of Panels and Platforms

scientific article published on 17 August 2015
TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

scientific article published on 16 October 2017
Bladder cancer: Multi-omic profiling refines the molecular view

scientific article
Fibroblast growth factors and their receptors in transitional cell carcinoma

scientific article
Metabolism and binding of benzo(a)pyrene and 2-acetylaminofluorene by short-term organ cultures of human and rat bladder

scientific article published on 01 February 1982
An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer

scientific article published on 14 June 2013
Mutational landscape of non-muscle-invasive bladder cancer

scientific article published on 13 November 2018
Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation

scientific article
In vitro functional effects of XPC gene rare variants from bladder cancer patients

scientific article
Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients

scientific article
Polycomb Repressor Complex 1 Member, BMI1 Contributes to Urothelial Tumorigenesis through p16-Independent Mechanisms

scientific article published on October 2015
Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis

scientific article published on 25 October 2017
The structure of tumours derived from mouse submandibular gland epithelium transformed in vitro

scientific article published on February 1, 1978
Ultrastructure and biological markers of neoplastic change in adult mouse epithelial cells transformed in vitro

scientific article published on April 1, 1978
Use of Aleuria alantia Lectin Affinity Chromatography to Enrich Candidate Biomarkers from the Urine of Patients with Bladder Cancer

scientific article published on 03 September 2015
ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer

scientific article published on 05 April 2019
Effects of the Tumor-Promoting Agent 12-O-Tetradecanoylphorbol-13-acetate on Normal and “Preneoplastic” Mouse Submandibular Gland Epithelial Cells In Vitro

scientific article published on February 1, 1979
Inactivation of the retinoblastoma susceptibility gene in metachronous eye and bladder tumours

scientific article published on 01 March 1998
Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling

scientific article published on 14 March 2022
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

scientific article published on 16 April 2021

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