List of works - Margaret A Knowles

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity

scientific article published on January 2015

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

scientific journal article

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

scientific article

Oncogenic FGFR3 gene fusions in bladder cancer

scientific article published on 21 November 2012

Distinct microRNA alterations characterize high- and low-grade bladder cancer

scientific article published on 20 October 2009

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer

scientific article published on 29 September 2009

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

scientific article

Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine

scientific article published on 3 September 2013

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

scientific article

Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma

scientific article published on December 2009

High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization

scientific article published on March 2004

Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium

scientific article published on July 2010

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

scientific article

MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer

scientific article

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

scientific article

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

scientific article published on March 15, 1998

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

scientific article published on July 24, 1997

Gene Expression Signatures Predict Outcome in Non-Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

article

Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder

scientific article published on April 1, 1991

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining

scientific article published on 5 October 2004

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

scientific article

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges

scientific article published on July 31, 2012

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer

scientific article published on 19 May 2009

Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival

scientific article

Identification of mutations in distinct regions of p85 alpha in urothelial cancer

scientific article

Molecular pathogenesis of bladder cancer

scientific article published on 15 August 2008

Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target

scientific article published on 03 October 2007

A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene

scientific article

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency

scientific article published in November 2017

A meckelin-filamin A interaction mediates ciliogenesis

scientific article

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer

scientific article published on 6 June 2013

Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes

scientific article

Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease

scientific article

Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis

scientific article published on 29 August 2012

Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes

scientific article

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

scientific article

Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers

scientific article published on 26 February 2013

Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines

scientific article published on November 2005

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma

scientific article published on 01 December 1991

Patterns of expression of DNA repair genes and relapse from melanoma

scientific article

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors

scientific article

Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors

scientific article published on February 2008

FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism

scientific article published on 30 April 2014

Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines

scientific article published on May 2002

Mechanisms of FGFR3 actions in endocrine resistant breast cancer

scientific article published on August 29, 2011

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer

scientific article

Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells

scientific article

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.

scientific article published on November 2003

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro

scientific article

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms

scientific article published on 7 April 2008

List of works by Margaret A Knowles

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

Oncogenic FGFR3 gene fusions in bladder cancer

Distinct microRNA alterations characterize high- and low-grade bladder cancer

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma

High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization

Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

Gene Expression Signatures Predict Outcome in Non-Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer

Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival

Identification of mutations in distinct regions of p85 alpha in urothelial cancer

Molecular pathogenesis of bladder cancer

Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target

A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency

A meckelin-filamin A interaction mediates ciliogenesis

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer

Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes

Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease

Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis

Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers

Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma

Patterns of expression of DNA repair genes and relapse from melanoma

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors

Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors

FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism

Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines

Mechanisms of FGFR3 actions in endocrine resistant breast cancer

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer

Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms