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List of works by Margaret A Knowles

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges ⬇️

scientific article published on July 31, 2012

A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene

scientific article

A meckelin-filamin A interaction mediates ciliogenesis

scientific article

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

scientific journal article

A place for precision medicine in bladder cancer: targeting the FGFRs ⬇️

scientific article

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

scientific article

Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3. ⬇️

scientific article published on 15 September 2014

Altered Splicing of FGFR1 Is Associated with High Tumor Grade and Stage and Leads to Increased Sensitivity to FGF1 in Bladder Cancer ⬇️

scientific article published on October 1, 2010

Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines

scientific article published on November 2005

Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder ⬇️

scientific article published on April 1, 1991

An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer ⬇️

scientific article published on 14 June 2013

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

scientific article published on 16 April 2021

Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma

scientific article published on December 2009

Assessing the quality of studies on the diagnostic accuracy of tumor markers ⬇️

scientific article

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro

scientific article

Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium

scientific article published on July 2010

Bladder cancer subtypes defined by genomic alterations

scientific article published on September 2008

Bladder cancer: Multi-omic profiling refines the molecular view ⬇️

scientific article

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms

scientific article published on 7 April 2008

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis

scientific article

Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine

scientific article published on 3 September 2013

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene ⬇️

scientific article published on July 24, 1997

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining

scientific article published on 5 October 2004

Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma

scientific article published on May 2010

Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder ⬇️

scientific article published on December 14, 2001

Distinct microRNA alterations characterize high- and low-grade bladder cancer

scientific article published on 20 October 2009

ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer

scientific article published on 05 April 2019

Effects of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate on normal and "preneoplastic" mouse submandibular gland epithelial cells in vitro

scientific article published on February 1, 1979

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

scientific article

Expression of Engrailed-2 (EN2) protein in bladder cancer and its potential utility as a urinary diagnostic biomarker

scientific article published on 21 February 2013

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

scientific article

FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism ⬇️

scientific article published on 30 April 2014

Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative therapeutic target for a small subgroup ⬇️

scientific article published on 22 September 2016

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer

scientific article published on 19 May 2009

Fibroblast growth factors and their receptors in transitional cell carcinoma

scientific article

Frequency of TERT Promoter Mutations in Prostate Cancer

scientific article

Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes ⬇️

scientific article

Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients

scientific article

Gene Expression Signatures Predict Outcome in Non-Muscle-Invasive Bladder Carcinoma: A Multicenter Validation Study

article

Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival

scientific article

Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells

scientific article

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

scientific article published on 26 May 2014

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency ⬇️

scientific article published in November 2017

High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma

scientific article

High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization

scientific article published on March 2004

High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder

scientific article

Human papillomavirus sequences are not detectable by Southern blotting or general primer-mediated polymerase chain reaction in transitional cell tumours of the bladder

scientific article published on January 1, 1992

Identification and Characterization of the Human Homologue of SH3BP2, an SH3 Binding Domain Protein within a Common Region of Deletion at 4p16.3 Involved in Bladder Cancer ⬇️

scientific article published on September 1, 1997

Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor

scientific article

Identification of mutations in distinct regions of p85 alpha in urothelial cancer

scientific article

In vitro functional effects of XPC gene rare variants from bladder cancer patients ⬇️

scientific article

Inactivation of the retinoblastoma susceptibility gene in metachronous eye and bladder tumours ⬇️

scientific article published on 01 March 1998

Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity.

scientific article

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).

scientific article published on August 2009

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. ⬇️

scientific article

Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss.

scientific article published on January 2005

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma

scientific article published on 01 December 1991

MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer

scientific article

Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligation-dependent probe amplification

scientific article

Mechanisms of FGFR3 actions in endocrine resistant breast cancer ⬇️

scientific article published on August 29, 2011

Metabolism and binding of benzo(a)pyrene and 2-acetylaminofluorene by short-term organ cultures of human and rat bladder ⬇️

scientific article published on 01 February 1982

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity ⬇️

scientific article published on January 2015

Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines

scientific article published on May 2002

Molecular pathogenesis of bladder cancer

scientific article published on 15 August 2008

Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling

scientific article published on 14 March 2022

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

scientific article

Molecular subtyping of invasive bladder cancer: time to divide and rule? ⬇️

scientific article published on February 2014

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors

scientific article

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer

scientific article

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.

scientific article published on November 2003

Mutational landscape of non-muscle-invasive bladder cancer

scientific article published on 13 November 2018

Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease

scientific article

Necdin: a multi functional protein with potential tumor suppressor role?

scientific article published in November 2009

Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors

scientific article published on February 2008

Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis

scientific article published on 29 August 2012

Oncogenic FGFR3 gene fusions in bladder cancer

scientific article published on 21 November 2012

PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs ⬇️

scientific article published on March 19, 2012

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities

scientific article

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer ⬇️

scientific article published on 6 June 2013

Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation. ⬇️

scientific article

Patterns of expression of DNA repair genes and relapse from melanoma

scientific article

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

scientific article

Polycomb Repressor Complex 1 Member, BMI1 Contributes to Urothelial Tumorigenesis through p16-Independent Mechanisms ⬇️

scientific article published on October 2015

Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers

scientific article published on 26 February 2013

Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target

scientific article published on 03 October 2007

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

scientific article

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer

scientific article published on 29 September 2009

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33 ⬇️

scientific article published on March 15, 1998

Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant

scientific article

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p ⬇️

scientific article published on 16 October 2017

The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study ⬇️

scientific article published on March 2015

The structure of tumours derived from mouse submandibular gland epithelium transformed in vitro ⬇️

scientific article published on February 1, 1978

Towards a Next-Generation Sequencing Diagnostic Service for Tumour Genotyping: A Comparison of Panels and Platforms ⬇️

scientific article published on 17 August 2015

Tumor suppressor loci in bladder cancer

scientific article published on January 2007

Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes

scientific article

Ultrastructure and biological markers of neoplastic change in adult mouse epithelial cells transformed in vitro ⬇️

scientific article published on April 1, 1978

Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis ⬇️

scientific article published on 25 October 2017

Use of Aleuria alantia Lectin Affinity Chromatography to Enrich Candidate Biomarkers from the Urine of Patients with Bladder Cancer ⬇️

scientific article published on 03 September 2015

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