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List of works by Gary Ruvkun

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

scientific article

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation

scientific article published in December 1996

A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum

scientific article published on January 2000

A common theme for LIM homeobox gene function across phylogeny?

scientific article published on 01 December 1998

A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans

scientific article

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

scientific article published in February 2004

A cytoprotective perspective on longevity regulation

scientific article

A general method for site-directed mutagenesis in prokaryotes ⬇️

scientific article published on January 1, 1981

A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans

scientific article

A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport

scientific article published on July 2016

A novel repeat domain that is often associated with RING finger and B-box motifs.

scientific article

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

scientific article (publication date: 8 August 1996)

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

scientific article

A systematic RNAi screen for longevity genes in C. elegans

scientific article

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

scientific article (publication date: 2003)

A uniform system for microRNA annotation

scientific article

A whole-genome RNAi Screen for C. elegans miRNA pathway genes

scientific article

Acceleration profiles and processing methods for parabolic flight

Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity

scientific article

Advancing the search for extra-terrestrial genomes

Aging, life span, and senescence ⬇️

scientific article published on September 15, 1998

Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.

scientific article

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans ⬇️

scientific article published on February 1, 1998

An image analysis toolbox for high-throughput C. elegans assays

scientific article

Analysis of xbx genes in C. elegans

scientific article published in April 2005

Biosynthesis of the Caenorhabditis elegans dauer pheromone ⬇️

scholarly article

C. elegans major fats are stored in vesicles distinct from lysosome-related organelles

scientific article

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons

scientific article published in February 1992

CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene

scientific article published in June 2024

Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons

scientific article published on 02 March 2020

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor ⬇️

scientific article published on August 15, 1998

Caenorhabditis elegans has scores of homoeobox-containing genes

scientific article published on September 1989

Caenorhabditis elegans pathways that surveil and defend mitochondria

scientific article

Caenorhabditis elegans responses to bacteria from its natural habitats

scientific article published on 17 June 2016

Cancer. Germ cell genes and cancer

scientific article published in December 2010

CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing

scientific article published on 27 March 2018

Cell signalling. A molecular growth industry

scientific article published on December 24, 1992

Clarifications on miRNA and cancer

scientific article published on 01 January 2006

Computational and experimental identification of C. elegans microRNAs

scientific article

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

scientific article (publication date: 2 November 2000)

Control of Neural Development and Function in a Thermoregulatory Network by the LIM Homeobox Genelin-11 ⬇️

scientific article published on March 15, 1998

Control of developmental timing by micrornas and their targets

scientific article

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis

scientific article

Correction: RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans.

scientific article published on 15 December 2009

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

scientific article published on 21 April 2013

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells

scientific article

DAF-16 target genes that control C. elegans life-span and metabolism.

scientific article published on 10 April 2003

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

scientific article published in Nature Communications

Detection of broadly expressed neuronal genes in C. elegans

scientific article published on 15 September 2006

Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization

scientific article published on February 1990

Dialogue between E. coli free radical pathways and the mitochondria of C. elegans

scientific article

Directed transposon Tn5 mutagenesis and complementation analysis of rhizobium meliloti symbiotic nitrogen fixation genes ⬇️

scientific article published on June 1, 1982

Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes

scientific article published on 01 January 1991

Dual regulation of the lin-14 target mRNA by the lin-4 miRNA.

scientific article

Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of

scientific article published on 04 October 2018

Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

scientific article published on 11 April 2019

Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?

scientific article

Fat metabolism links germline stem cells and longevity in C. elegans

scientific article

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant

scientific article

Functional genomic analysis of C. elegans molting

scientific article

Functional genomic analysis of RNA interference in C. elegans

scientific article (publication date: 20 May 2005)

Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways

scientific article

Functional tests of enhancer conservation between distantly related species

scientific article published on 27 August 2003

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants

scientific article

Gene pathways that delay Caenorhabditis elegans reproductive senescence

scientific article (publication date: December 2014)

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

scientific article (publication date: 13 July 2001)

Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans

scientific article published on 21 May 2008

Genetic regulation of Caenorhabditis elegans lysosome related organelle function

scientific article

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

scientific article (publication date: 16 January 2003)

Genomic and Functional Characterization of <i>Enterococcus faecalis</i> Isolates Recovered From the International Space Station and Their Potential for Pathogenicity

scientific article published on 01 January 2020

Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal

scientific article

Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans

scientific article

Heterochronic genes in development and evolution

scientific article published on 01 December 1998

High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis

scientific article

High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes

scientific article published on 30 January 2013

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.

scientific article published on October 2013

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis

scientific article published on 25 April 2019

Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism

scientific article published in February 2024

Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans

scientific article published on 13 February 2024

ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes

scientific article published on January 1, 1982

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains

scientific article published on 01 January 2007

Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans

scientific article

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

scientific article

Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence

scientific article published on 23 December 2012

Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses

scientific article published on April 2012

Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways

scientific article (publication date: 2012)

Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway

scientific article

Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.

scientific article published on 17 March 2004

Interspecies homology of nitrogenase genes

scientific article

Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.

scientific article

Lifespan regulation by evolutionarily conserved genes essential for viability

scientific article

Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis

scientific article

Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans

scientific article

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

scientific article

Longevity: don't hold your breath

scientific article

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism

scientific article published on 31 July 2020

MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans

scientific article

MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation

scientific article

MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline

scientific article

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

scientific article published on 21 April 2013

MicroRNA-183 family conservation and ciliated neurosensory organ expression

scientific article

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

scientific article

MicroRNAs visit the ER.

scientific article published in April 2013

Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars

scientific article published on 26 September 2017

Miniprimer PCR, a new lens for viewing the microbial world

scientific article

Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs

scientific article

Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes

scientific article published on 21 February 2019

Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response

scientific article published on 02 December 2020

Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa

scientific article

Molecular biology. Glimpses of a tiny RNA world

scientific article

Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.

scientific article

Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification

scientific article published on 25 March 2019

Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans

scientific article published on December 2013

Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans

scientific article published on 11 July 2024

Nanopore sequencing at Mars, Europa, and microgravity conditions

scientific article published on 07 September 2020

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development

scientific article

Nematode homeobox cluster ⬇️

scientific article published on June 27, 1991

New insights into siRNA amplification and RNAi ⬇️

scientific article published on August 1, 2012

New motif in PBX genes

scientific article published on August 1, 1992

Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection ⬇️

scientific article published on 11 June 2019

Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection

scientific article published on 13 July 2017

PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.

scientific article

Pathogens

scientific article published on January 2014

Patterning the Nervous System ⬇️

scientific article published on March 18, 2011

Pax genes in Caenorhabditis elegans: a new twist

scientific article published on 01 June 1999

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

scientific journal article

PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles

scientific article published on 9 May 2015

Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis ⬇️

scientific article published on January 1, 1982

Planetary Protection and Mars Special Regions--A Suggestion for Updating the Definition

scientific article published on 05 February 2016

Polygenic control of Caenorhabditis elegans fat storage

scientific article published on 5 February 2006

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

scientific article (publication date: 3 December 1993)

Prediction of C. elegans longevity genes by human and worm longevity networks

scientific article published on 29 October 2012

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.

scientific article published on 16 August 2016

Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression

scientific article published on 01 April 2019

Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death

scientific article

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans

scientific article

RNAi screening for fat regulatory genes with SRS microscopy

scientific article

ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants

scientific article published on 07 October 2019

Radiation resistance of biological reagents for in situ life detection

scientific article published on January 2013

Radiation resistance of sequencing chips for in situ life detection

scientific article published on 04 June 2013

Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs

scientific article published on 01 July 2018

Regulation and Functions of the ER-Associated Nrf1 Transcription Factor

scientific article published in 2022

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

scientific article published in December 2001

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

scientific article

Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway

scientific article published on 01 January 2004

Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes

scientific article published on 04 June 2019

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

scientific article

Regulation of Interneuron Function in the C. elegans Thermoregulatory Pathway by the ttx-3 LIM Homeobox Gene ⬇️

scientific article published on August 1, 1997

Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.

scientific article

Regulation of the C. elegans molt by pqn-47.

scientific article

Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3 ⬇️

scientific article published on December 1, 1992

Regulation of transcription and cell identity by POU domain proteins

scientific article published on February 1991

Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes

scientific article (publication date: 2012)

Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells

scientific article published on 11 February 2019

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

scientific article published on February 2009

Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection

scientific article published on 16 May 2018

Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants

scientific article published in July 2005

Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts ⬇️

scientific article published on 01 June 1982

Systematic analysis of genes required for synapse structure and function

scientific article published in July 2005

Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network

scientific article published on February 2004

Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation

scientific article published in August 1994

Temporal pattern formation by heterochronic genes

scientific article published on January 1997

Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.

scientific article

The 20 years it took to recognize the importance of tiny RNAs

scientific article

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

scientific article (publication date: 24 February 2000)

The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status

scientific article published on 28 November 2011

The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons

scientific article

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

scientific journal article

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors

scientific article

The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification

scientific article

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.

scientific article

The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.

scientific article published in July 1996

The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function

scientific article published in August 2003

The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch

scientific article

The Caenorhabditis elegans homeobox gene cluster

scientific article published on August 1993

The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons

scientific article published in April 1999

The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development

scientific article published in April 1997

The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway ⬇️

scientific article published on October 15, 1997

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications

scientific article

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans ⬇️

scientific article published on October 30, 1997

The Genetics of Aging ⬇️

scientific article published on 01 January 2001

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products

scientific article

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi

scientific article

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

scientific article (publication date: April 2000)

The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans ⬇️

scientific article published on March 6, 2012

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions

scientific article

The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25

scientific article

The most conserved genome segments for life detection on Earth and other planets

scientific article published on 14 October 2008

The perfect storm of tiny RNAs

scientific article

The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes.

scientific article

The taxonomy of developmental control in Caenorhabditis elegans

scientific article

The tiny RNA world.

scientific article

The unc-86 gene product couples cell lineage and cell identity in C. elegans

scientific article published in November 1990

Themes from a NASA workshop on gene regulatory processes in development and evolution

scientific article

Tiny RNA: Where do we come from? What are we? Where are we going?

scientific article

Towards in situ sequencing for life detection

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

scientific article published on 10 September 2008

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility

scientific article published on 01 September 2021

Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling

scientific article (publication date: July 2006)

Unraveling the secrets of the cell

scientific article published on 01 December 2003

VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth.

scientific article published in March 1997

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans ⬇️

scientific article published on August 15, 1997

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans

scientific article

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway

scientific article

mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans

scientific article

piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway

scientific article

ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy

scientific article published on 7 February 2013

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