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List of works by José Portugal

A comparative analysis of the time-dependent antiproliferative effects of daunorubicin and WP631.

scientific article

A model for the ability of drugs to induce enhanced DNase I cleavage

scientific article published on 01 July 1989

A new bisintercalating anthracycline with picomolar DNA binding affinity.

scientific article published on December 2005

A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells.

scientific article published on 5 April 2009

A theoretical perusal of the satellite DNA curvature in tenebrionid beetles.

scientific article published on August 1998

Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe

scientific article published on 07 August 2012

Assignment of DNA binding sites for 4',6-diamidine-2-phenylindole and bisbenzimide (Hoechst 33258). A comparative footprinting study

scientific article

Autophagy modulates the effects of bis-anthracycline WP631 on p53-deficient prostate cancer cells

scientific article

Berenil acts as a poison of eukaryotic topoisomerase II

scientific article published on 01 May 1994

Berenil recognizes and changes the characteristics of adenine and thymine polynucleotide structures

scientific article published on 01 October 1993

Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro.

scientific article published on September 1999

Calorimetric and spectroscopic studies on the poly[d(GA).d(CT)] structural polymorphism induced by zinc

scientific article published on 01 August 1994

Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells

scientific article published on 4 December 2009

Challenging transcription by DNA-binding antitumor drugs

scientific article published on 21 July 2018

Changes in gene expression induced by Sp1 knockdown differ from those caused by challenging Sp1 binding to gene promoters ⬇️

scientific article published on June 13, 2011

Characterization of monoclonal gammopathy of undetermined significance by calorimetric analysis of blood serum proteome

scientific article

Chartreusin, elsamicin A and related anti-cancer antibiotics.

scientific article published on November 2003

Circumvention of the multidrug-resistance protein (MRP-1) by an antitumor drug through specific inhibition of gene transcription in breast tumor cells

scientific article published on 10 December 2006

Comparison of binding sites in DNA for berenil, netropsin and distamycin. A footprinting study

scientific article published on 01 September 1987

Cytotoxic effects of mithramycin DIG-MSK can depend on the rise of autophagy

scientific article published on 12 June 2015

DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis

scientific article published on 16 November 2010

Daunorubicin-induced variations in gene transcription: commitment to proliferation arrest, senescence and apoptosis

scientific article published on June 2003

Detection of elsamicin-DNA binding specificity by restriction enzyme cleavage

scientific article published on 01 March 1992

Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships

scientific article

Do Hoogsteen base pairs occur in DNA?

scientific article published on 01 April 1989

Drug interactions with nucleosomes and chromatin

scientific article published on 01 January 2001

Elsamicin A binding to DNA. A comparative thermodynamic characterization.

scientific article

Elsamicin A can convert the Z-form of poly[d(G-C)] and poly[(G-m5C)] back to B-form DNA

scientific article published on 01 November 1992

Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences

scientific article published on 16 March 2007

Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity

scientific article published in 2009

Experimental and modelling studies on the DNA cleavage by elsamicin A

scientific article published on 01 September 1992

Exploiting anthracycline scaffold for designing DNA-targeting agents

scientific article published on 01 January 2001

Footprinting analysis of sequence-specific DNA-drug interactions.

scientific article published on January 1989

Genome-wide modulation of gene transcription in ovarian carcinoma cells by a new mithramycin analogue

scientific article

Genomewide expression profiling of cryptolepine-induced toxicity in Saccharomyces cerevisiae

scientific article published on 18 August 2008

High resolution derivative denaturation profiles of DNA in the presence of copper(II) ions

scientific article published in October 1989

Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA

scientific article published on 01 December 1987

Induction of G2/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes

article

Influence of elsamicin A on the activity of mammalian topoisomerase I.

scientific article published in August 1996

Insights into DNA-drug interactions in the era of omics

scientific article published on 15 June 2020

Interaction of nucleosome core particles with distamycin and echinomycin: analysis of the effect of DNA sequences.

scientific article published on February 1987

MALDI-TOF analysis of blood serum proteome can predict the presence of monoclonal gammopathy of undetermined significance

scientific article published in PLoS ONE

Map of chartreusin and elsamicin binding sites on DNA

scientific article published on 01 November 1991

Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells

scientific article

Mitotic catastrophe as a consequence of chemotherapy.

scientific article published on November 2006

Mitotic catastrophe results in cell death by caspase-dependent and caspase-independent mechanisms.

scientific article published on 21 January 2006

Modulation of DNA-protein interactions in the P1 and P2 c-myc promoters by two intercalating drugs.

scientific article

Molecular Dynamics Study of the Binding of Elsamicin A to DNA

scientific article published in June 1995

Noncovalent Binding to DNA: Still a Target in Developing Anticancer Agents

scientific article

Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.

scientific article

Polymorphic curvature of satellite DNA in three subspecies of the beetle Pimelia sparsa.

scientific article published on March 1997

Promoter-specific inhibition of transcription by daunorubicin in Saccharomyces cerevisiae

scientific article published in November 2002

Selective inhibition of yeast regulons by daunorubicin: a transcriptome-wide analysis

scientific article

Small ligands that neither bind to nor alter the structure of d(GA x TC)n sequences in DNA.

scientific article

Sp1 transcription factor as a target for anthracyclines: effects on gene transcription.

scientific article published on 05 January 2008

Sp1 transcription factor: A long-standing target in cancer chemotherapy

scientific article published on 08 May 2015

Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes.

scientific article published in June 2004

The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.

scientific article

The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells

scientific article

The tertiary structure of the four-way DNA junction affords protection against DNase I cleavage

scientific article published on May 1990

Transcriptional changes facilitate mitotic catastrophe in tumour cells that contain functional p53.

scientific article

Transport-related airborne nanoparticles: Sources, different aerosol modes, and their toxicity

scientific article published in 2023

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