List of works - Chu Wang

A Dimethyl-Labeling-Based Strategy for Site-Specifically Quantitative Chemical Proteomics

scholarly article by Fan Yang et al published 10 July 2018 in Analytical Chemistry

A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

scientific article published on December 2013

A chemoselective reaction between protein N-homocysteinylation and azides catalyzed by heme(ii)

scientific article published on 01 March 2019

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

scientific article

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

scientific article

Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice

scientific article published in 2021

Activity-based Protein Profiling

Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling

scientific article published on 13 December 2017

Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts

scientific article published on 25 October 2017

Chemical proteomic profiling of protein N-homocysteinylation with a thioester probe.

scientific article

Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function

Chemoproteomic Profiling of Bile Acid Interacting Proteins

scientific article

Chemoproteomic Profiling of O-GlcNAcylation in Caenorhabditis elegans

scientific article published on 04 November 2019

Chemoproteomic profiling of protein modifications by lipid-derived electrophiles

scientific article

Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe

scientific article

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

scientific article

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().

scientific article

Conformational and functional significance of residue proline 17 in chicken muscle adenylate kinase

scientific article published in November 2001

Cryo-EM structure of human mitochondrial trifunctional protein

article published in the Proceedings of the National Academy of Sciences of the United States of America

Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging

scientific article published on 2 May 2006

Design of activated serine–containing catalytic triads with atomic-level accuracy

scientific article

Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome

scientific article published on July 2012

Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label

scientific article published on 27 July 2016

Global Mapping of Metalloproteomes

scientific article published in 2021

Global profiling of dynamic protein palmitoylation

scientific article

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

scientific article

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

scientific article published on 5 September 2015

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

scientific article published on 10 September 2016

Improved side-chain modeling for protein-protein docking

scientific article

Investigating the proteome reactivity and selectivity of aryl halides

scientific article

KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia

scientific article published on 21 January 2022

Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

scientific article published in November 2011

Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling

scientific article published on 8 March 2016

Prediction of structures of zinc-binding proteins through explicit modeling of metal coordination geometry.

scientific article

Prediction of the structure of symmetrical protein assemblies

scholarly article

Profiling of post-translational modifications by chemical and computational proteomics

scientific article published on 21 October 2020

Progress in modeling of protein structures and interactions

scientific article

Progress in protein-protein docking: atomic resolution predictions in the CAPRI experiment using RosettaDock with an improved treatment of side-chain flexibility

scientific article

Protein-protein docking with backbone flexibility

scientific article published on 2 August 2007

Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations

scientific article (publication date: August 2003)

Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria

scientific article published on March 2013

Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors

scholarly article by Hongting Tang et al published 8 October 2018 in Journal of the American Chemical Society

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe

scientific article published on 23 March 2018

Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker

scientific article published on 30 July 2018

Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein

scientific article published on 15 January 2019

Quantitative reactivity profiling predicts functional cysteines in proteomes

scientific article

Quantitative time-resolved chemoproteomics reveals that stable O-GlcNAc regulates box C/D snoRNP biogenesis

scientific article published on 31 July 2017

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

scientific article published on 22 May 2019

RosettaDock in CAPRI rounds 6-12

scientific article (publication date: December 2007)

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

scientific article published on 22 July 2019

Selenium-Encoded Isotopic Signature Targeted Profiling

Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning.

scientific article published on 26 October 2017

Site-specific chemoproteomic profiling of targets of glyoxal

scientific article published on 30 October 2019

Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home

scientific article

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

scientific article published on 10 May 2021

Target discovery of ebselen with a biotinylated probe

scientific article published on 01 August 2018

List of works by Chu Wang

A Dimethyl-Labeling-Based Strategy for Site-Specifically Quantitative Chemical Proteomics

A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

A chemoselective reaction between protein N-homocysteinylation and azides catalyzed by heme(ii)

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice

Activity-based Protein Profiling

Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling

Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts

Chemical proteomic profiling of protein N-homocysteinylation with a thioester probe.

Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function

Chemoproteomic Profiling of Bile Acid Interacting Proteins

Chemoproteomic Profiling of O-GlcNAcylation in Caenorhabditis elegans

Chemoproteomic profiling of protein modifications by lipid-derived electrophiles

Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().

Conformational and functional significance of residue proline 17 in chicken muscle adenylate kinase

Cryo-EM structure of human mitochondrial trifunctional protein

Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging

Design of activated serine–containing catalytic triads with atomic-level accuracy

Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome

Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label

Global Mapping of Metalloproteomes

Global profiling of dynamic protein palmitoylation

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

Improved side-chain modeling for protein-protein docking

Investigating the proteome reactivity and selectivity of aryl halides

KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia

Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling

Prediction of structures of zinc-binding proteins through explicit modeling of metal coordination geometry.

Prediction of the structure of symmetrical protein assemblies

Profiling of post-translational modifications by chemical and computational proteomics

Progress in modeling of protein structures and interactions

Progress in protein-protein docking: atomic resolution predictions in the CAPRI experiment using RosettaDock with an improved treatment of side-chain flexibility

Protein-protein docking with backbone flexibility

Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations

Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria

Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe

Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker

Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein

Quantitative reactivity profiling predicts functional cysteines in proteomes

Quantitative time-resolved chemoproteomics reveals that stable O-GlcNAc regulates box C/D snoRNP biogenesis

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

RosettaDock in CAPRI rounds 6-12

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

Selenium-Encoded Isotopic Signature Targeted Profiling

Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning.

Site-specific chemoproteomic profiling of targets of glyoxal

Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

Target discovery of ebselen with a biotinylated probe