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List of works by Khandan Keyomarsi

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

scientific article

A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer

scientific article published on 7 May 2015

AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers.

scientific article published on 26 September 2016

Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells.

scientific article published on 29 December 2003

Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation.

scientific article published on 24 March 2009

An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

scientific article

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

scientific article

Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.

scientific article published on October 2008

Biomarkers in Neoadjuvant Trials

scientific article published on 01 January 2009

Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles ⬇️

scientific article published on November 30, 2011

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.

scientific article

CDK4/6 inhibitors sensitize Rb-positive sarcoma cells to Wee1 kinase inhibition through reversible cell cycle arrest.

scientific article published on 15 June 2017

Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E

scientific article

Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells.

scientific article published on 29 February 2016

Cyclin E deregulation alters the biologic properties of ovarian cancer cells.

scientific article published on April 2004

Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C.

scientific article

Cyclin E deregulation is an early event in the development of breast cancer.

scientific article published on 24 December 2008

Cyclin E is a more powerful predictor of breast cancer outcome than proliferation

scientific article published on 01 February 2003

Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer.

scientific article published on 17 January 2017

Cyclin E-associated kinase activity predicts response to platinum-based chemotherapy.

scientific article published on August 2007

Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors in Breast Cancer.

scientific article published on 25 September 2017

Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer

scientific article published on 23 November 2016

Cytoplasmic Cyclin E and Phospho-Cyclin-Dependent Kinase 2 Are Biomarkers of Aggressive Breast Cancer

scientific article published on 13 May 2016

DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer

scientific article published on 26 May 2009

Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer

scientific article published on December 2006

Differential regulation of elafin in normal and tumor-derived mammary epithelial cells is mediated by CCAAT/enhancer binding protein beta.

scientific article published in December 2007

Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence

scientific article

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer

scientific article published on 15 January 2013

Erratum to "Expression of an estrogen receptor alpha variant protein in cell lines and tumors"

scientific article published in August 2000

Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence.

scientific article published on 25 June 2015

Estrogen receptor alpha is cell cycle-regulated and regulates the cell cycle in a ligand-dependent fashion

scientific article published on 06 April 2016

Expression of an estrogen receptor alpha variant protein in cell lines and tumors

scientific article published on 01 April 2000

Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.

scientific article published in January 2006

Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells.

scientific article published on 16 August 2013

How will we recruit, train, and retain physicians and scientists to conduct translational cancer research?

scientific article

Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells

scientific article

Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions.

scientific article published on 7 December 2017

LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients ⬇️

scientific article published on March 29, 2012

Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

scientific article

Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer ⬇️

scientific article published on April 1, 2012

Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification

scientific article

Low-molecular-weight cyclin E: the missing link between biology and clinical outcome

scientific article

MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells.

scientific article published on 06 May 2011

Modification of cell proliferation with inhibitors

scientific article published on April 1, 1992

Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway.

scientific article published in August 2007

PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

scientific article published on 4 February 2016

PKCiota promotes ovarian tumor progression through deregulation of cyclin E.

scientific article published on 17 August 2015

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

scientific article (publication date: 5 October 2001)

Role of cell cycle in mediating sensitivity to radiotherapy

scientific article published in July 2004

Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells

scientific article published on 19 September 2010

Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer

scientific article published on 29 January 2016

Staurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner

scientific article published on 30 May 2013

Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.

scientific article

Targeting low molecular weight cyclin E (LMW-E) in breast cancer.

scientific article published on 22 June 2011

The biphasic induction of p21 and p27 in breast cancer cells by modulators of cAMP is posttranscriptionally regulated and independent of the PKA pathway.

scientific article published on October 1999

The neutrophil elastase inhibitor elafin triggers rb-mediated growth arrest and caspase-dependent apoptosis in breast cancer.

scientific article

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

scientific article

The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase

scientific article

Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms

scientific article

[47] Preparation of (6S)-5-formyltetrahydrofolate labeled at high specific activity with 14C and 3H

scientific article published on 01 January 1986

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