List of works - Graham Knott

3D Ultrastructure of Synaptic Inputs to Distinct GABAergic Neurons in the Mouse Primary Visual Cortex

scientific article published on 22 December 2020

A protocol for preparing GFP-labeled neurons previously imaged in vivo and in slice preparations for light and electron microscopic analysis

scientific article

A single epidermal stem cell strategy for safe ex vivo gene therapy.

scientific article

ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

scientific article published in 2022

Albumin transfer across the choroid plexus of South American opossum (Monodelphis domestica).

scientific article published in February 1997

Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice.

scientific article published in March 2004

Altered synaptic dynamics during normal brain aging.

scientific article

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

scientific article published on 08 August 2018

Analysis of centriole elimination during C. elegans oogenesis

scientific article

Automated detection and segmentation of synaptic contacts in nearly isotropic serial electron microscopy images

scientific article published in 2011

BMP signaling specifies the development of a large and fast CNS synapse.

scientific article published on 26 May 2013

Barriers in the immature brain

scientific article

Block Face Scanning Electron Microscopy of Fluorescently Labeled Axons Without Using Near Infra-Red Branding

scientific article published on 06 November 2018

Carving: Scalable Interactive Segmentation of Neural Volume Electron Microscopy Images

scientific article published on 01 January 2011

Cell Division by Longitudinal Scission in the Insect Endosymbiont Spiroplasma poulsonii

scientific article

Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex

scientific article published in March 2006

Cellular Uptake and Intracellular Trafficking of Poly(N-(2-Hydroxypropyl) Methacrylamide)

scientific article published on 14 November 2018

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

scientific article

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

scientific article published on 23 June 2020

Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images.

scientific article published on 23 October 2017

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

scientific article

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

scientific article published on 2 March 2014

Correction: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

scientific article published on 28 October 2015

Correlative in vivo 2 photon and focused ion beam scanning electron microscopy of cortical neurons.

scientific article

Correlative in vivo 2-photon imaging and focused ion beam scanning electron microscopy: 3D analysis of neuronal ultrastructure.

scientific article

Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain

scientific article published on 13 September 2013

Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits

scientific article published on June 2015

Dendritic spine plasticity--current understanding from in vivo studies.

scientific article published on 19 March 2008

Development of motoneurons and primary sensory afferents in the thoracic and lumbar spinal cord of the South American opossum Monodelphis domestica

article

Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica)

article by Zolt�n Moln�r et al published 7 September 1998 in The Journal of Comparative Neurology

Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica).

scientific article published in September 1998

Development of walking, swimming and neuronal connections after complete spinal cord transection in the neonatal opossum, Monodelphis domestica

scientific article published on 01 January 1998

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study.

scientific article

Differential effect on myelination through abolition of activity-dependent synaptic vesicle release or reduction of overall electrical activity of selected cortical projections in the mouse

scientific article published on 22 March 2019

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

scientific article published on 20 August 2018

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

scientific article published on 21 July 2021

Efficient scanning for EM based target localization

scientific article published on 01 January 2012

Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period.

scientific article published in October 2004

Experience-dependent and cell-type-specific spine growth in the neocortex.

scientific article

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.

scientific article published on 24 October 2013

Fetuin expression in the dorsal root ganglia and trigeminal ganglia of perinatal rats

scientific article published on 01 October 1997

Flash scanning electron microscopy

scientific article published on 01 January 2013

Focussed ion beam milling and scanning electron microscopy of brain tissue.

scientific article

Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice.

scientific article published in April 2002

GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons.

scientific article published on January 2012

GCIB-SEM: A path to 10 nm isotropic imaging of cubic millimeter volumes

Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution

scientific article published on 18 November 2019

Glial glutamate transporters and maturation of the mouse somatosensory cortex

scientific article published in October 2003

Growth of axons through a lesion in the intact CNS of fetal rat maintained in long-term culture

article

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

scientific article published on 28 September 2016

Imaging green fluorescent protein-labeled neurons using light and electron microscopy.

scientific article

Imaging liver and brain glycogen metabolism at the nanometer scale

scientific article

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose.

scientific article published on 23 September 2015

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

scientific article published on 01 March 2020

In vivo modeling of human neuron dynamics and Down syndrome

scientific article published in Science

In vivo reactive neural plasticity investigation by means of correlative two photon: electron microscopy

In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex.

scientific article

In vivoimaging of neural reactive plasticity after laser axotomy in cerebellar cortex

scholarly article published 24 March 2014

In vivotwo-photon imaging of climbing fibers plasticity after laser axotomy

Increased axonal bouton dynamics in the aging mouse cortex

scientific article (publication date: 16 April 2013)

Increasing depth resolution of electron microscopy of neural circuits using sparse tomographic reconstruction

scientific article published in June 2010

Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton

scientific journal article

Is EM dead?

scientific article published on October 2013

Learning context cues for synapse segmentation

scientific article published on 11 June 2013

Learning context cues for synapse segmentation in EM volumes

scientific article published on 01 January 2012

Learning structured models for segmentation of 2-D and 3-D imagery.

scientific article published on 26 November 2014

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

scientific article published on 01 June 2018

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

scientific article (publication date: December 2002)

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

scientific article

Maturation of Complex Synaptic Connections of Layer 5 Cortical Axons in the Posterior Thalamic Nucleus Requires SNAP25

scientific article published on 26 December 2020

Mitonuclear protein imbalance as a conserved longevity mechanism

scientific article published on May 2013

Modeling brain circuitry over a wide range of scales ⬇️

scientific article

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

scientific article published on 3 November 2017

Molecular insights into Vibrio cholerae's intra-amoebal host-pathogen interactions

scientific article published in Nature Communications

Morphological and molecular heterogeneity in release sites of single neurons.

scientific article published in April 2003

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

scientific article published on 19 October 2017

Multi-Modal Optical Imaging of the Cerebellum in Animals

scientific article published on 17 October 2015

Multicut brings automated neurite segmentation closer to human performance

scientific article published in January 2017

Multiphoton microscopy in brain imaging

Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson's disease

scientific article published on 09 July 2020

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

scientific article published in October 2015

Neural plasticity explored by correlative two-photon and electron/SPIM microscopy

scholarly article published 17 June 2013

NeuroMorph: A Software Toolset for 3D Analysis of Neurite Morphology and Connectivity

scientific article published on 23 July 2018

NeuroMorph: a toolset for the morphometric analysis and visualization of 3D models derived from electron microscopy image stacks.

scientific article published on January 2015

Neurodegeneration: Cold shock protects the brain

scientific article published on 14 January 2015

Neuron Segmentation with High-Level Biological Priors.

scientific article published on 06 June 2017

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

scientific article published on 24 February 2012

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

scientific article published on 12 November 2021

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein

scientific article

PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling.

scientific article published on December 2008

Pansynaptic enlargement at adult cortical connections strengthened by experience.

scientific article

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

scientific article published on 4 January 2017

Permeability of the developing and mature blood-brain barriers to theophylline in rats.

scientific article published in May 1998

Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex

scientific article

Primary sensory afferent innervation of the developing superficial dorsal horn in the South American opossum Monodelphis domestica

scientific article published on 01 March 2006

Publisher Correction: Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution

scientific article published on 01 January 2020

Rapid functional maturation of nascent dendritic spines

scientific article

Repair and recovery following spinal cord injury in a neonatal marsupial (Monodelphis domestica)

scientific article published on 01 August 1995

SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans

scientific article

Semiautomated correlative 3D electron microscopy of in vivo-imaged axons and dendrites

scientific article

Serial Section Scanning Electron Microscopy of Adult Brain Tissue Using Focused Ion Beam Milling

scientific article published on 01 March 2008

Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1

scientific article published on 22 April 2020

Spine growth precedes synapse formation in the adult neocortex in vivo.

scientific article published on 6 August 2006

Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.

scientific article published on 10 October 2004

Supervoxel-based segmentation of mitochondria in em image stacks with learned shape features

scientific article published on 13 October 2011

Synapse formation in adult barrel cortex following naturalistic environmental enrichment

scientific article published on 30 October 2011

TGF-beta receptor type II and fetuin in the developing sheep neocortex.

scientific article

The Differential Distribution of RAPTA-T in Non-Invasive and Invasive Breast Cancer Cells Correlates with Its Anti-Invasive and Anti-Metastatic Effects.

scientific article published on 29 August 2017

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

scientific article published on 11 January 2019

The effects of aging on neuropil structure in mouse somatosensory cortex-A 3D electron microscopy analysis of layer 1

scientific article published in PLoS ONE

The nature and composition of the internal environment of the developing brain

scientific article

The nature of the decrease in blood-cerebrospinal fluid barrier exchange during postnatal brain development in the rat.

scientific article

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

scientific article published on 19 February 2020

The relationship between PSD-95 clustering and spine stability in vivo.

scientific article published in February 2014

Transient and persistent dendritic spines in the neocortex in vivo

scientific article (publication date: 20 January 2005)

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

scientific article

Ultrastructural basis of strong unitary inhibition in a binaural neuron

scientific article published on 02 September 2018

Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation

scientific article published on 04 December 2020

Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics

scientific article

List of works by Graham Knott

3D Ultrastructure of Synaptic Inputs to Distinct GABAergic Neurons in the Mouse Primary Visual Cortex

A protocol for preparing GFP-labeled neurons previously imaged in vivo and in slice preparations for light and electron microscopic analysis

A single epidermal stem cell strategy for safe ex vivo gene therapy.

ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels

Albumin transfer across the choroid plexus of South American opossum (Monodelphis domestica).

Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice.

Altered synaptic dynamics during normal brain aging.

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Analysis of centriole elimination during C. elegans oogenesis

Automated detection and segmentation of synaptic contacts in nearly isotropic serial electron microscopy images

BMP signaling specifies the development of a large and fast CNS synapse.

Barriers in the immature brain

Block Face Scanning Electron Microscopy of Fluorescently Labeled Axons Without Using Near Infra-Red Branding

Carving: Scalable Interactive Segmentation of Neural Volume Electron Microscopy Images

Cell Division by Longitudinal Scission in the Insect Endosymbiont Spiroplasma poulsonii

Cell type-specific structural plasticity of axonal branches and boutons in the adult neocortex

Cellular Uptake and Intracellular Trafficking of Poly(N-(2-Hydroxypropyl) Methacrylamide)

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images.

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

Correction: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

Correlative in vivo 2 photon and focused ion beam scanning electron microscopy of cortical neurons.

Correlative in vivo 2-photon imaging and focused ion beam scanning electron microscopy: 3D analysis of neuronal ultrastructure.

Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain

Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits

Dendritic spine plasticity--current understanding from in vivo studies.

Development of motoneurons and primary sensory afferents in the thoracic and lumbar spinal cord of the South American opossum Monodelphis domestica

Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica)

Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica).

Development of walking, swimming and neuronal connections after complete spinal cord transection in the neonatal opossum, Monodelphis domestica

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study.

Differential effect on myelination through abolition of activity-dependent synaptic vesicle release or reduction of overall electrical activity of selected cortical projections in the mouse

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model

Efficient scanning for EM based target localization

Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period.

Experience-dependent and cell-type-specific spine growth in the neocortex.

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.

Fetuin expression in the dorsal root ganglia and trigeminal ganglia of perinatal rats

Flash scanning electron microscopy

Focussed ion beam milling and scanning electron microscopy of brain tissue.

Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice.

GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons.

GCIB-SEM: A path to 10 nm isotropic imaging of cubic millimeter volumes

Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution

Glial glutamate transporters and maturation of the mouse somatosensory cortex

Growth of axons through a lesion in the intact CNS of fetal rat maintained in long-term culture

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

Imaging green fluorescent protein-labeled neurons using light and electron microscopy.

Imaging liver and brain glycogen metabolism at the nanometer scale

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose.

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

In vivo modeling of human neuron dynamics and Down syndrome

In vivo reactive neural plasticity investigation by means of correlative two photon: electron microscopy

In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex.

In vivoimaging of neural reactive plasticity after laser axotomy in cerebellar cortex

In vivotwo-photon imaging of climbing fibers plasticity after laser axotomy

Increased axonal bouton dynamics in the aging mouse cortex

Increasing depth resolution of electron microscopy of neural circuits using sparse tomographic reconstruction

Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton

Is EM dead?

Learning context cues for synapse segmentation

Learning context cues for synapse segmentation in EM volumes

Learning structured models for segmentation of 2-D and 3-D imagery.

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

Maturation of Complex Synaptic Connections of Layer 5 Cortical Axons in the Posterior Thalamic Nucleus Requires SNAP25

Mitonuclear protein imbalance as a conserved longevity mechanism

Modeling brain circuitry over a wide range of scales ⬇️

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

Molecular insights into Vibrio cholerae's intra-amoebal host-pathogen interactions

Morphological and molecular heterogeneity in release sites of single neurons.

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

Multi-Modal Optical Imaging of the Cerebellum in Animals

Multicut brings automated neurite segmentation closer to human performance

Multiphoton microscopy in brain imaging