List of works - Xi-Ping Huang

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

scientific article

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

scientific article

Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists.

scientific article published on 03 September 2013

Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors

scientific article published in March 2000

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs

scientific article published in November 2010

Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions

scientific article published on 10 September 2020

Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo

scientific article

Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor

scientific article published on 24 May 2012

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

scientific article

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

scientific article published on 13 March 2017

Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels

scientific article

Molecular control of δ-opioid receptor signalling

scientific article

Molecular interactions between general anesthetics and the 5HT2B receptor.

scientific article published on 23 December 2013

Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric lig

scientific article published on 28 November 2006

N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.

scientific article

Neurochemical profiles of some novel psychoactive substances

scientific article

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation

scientific article

Novel molecular targets of dezocine and their clinical implications

scientific article (publication date: March 2014)

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

scientific article published on 20 April 2015

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

scientific article

Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity

scientific article

Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

scientific article

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

scientific article

Structure of the human smoothened receptor bound to an antitumour agent

scientific article

Structure of the human κ-opioid receptor in complex with JDTic

scientific article

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

scientific article

Structure-based discovery of potent and selective melatonin receptor agonists

scientific article published on 02 March 2020

Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.

scientific article

The activities of drug inactive ingredients on biological targets

scientific article

The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs

scientific article

The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor

scientific article published in 2013

trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family

scientific article

σ1 receptor ligands control a switch between passive and active threat responses

scientific article

List of works by Xi-Ping Huang

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo

Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists.

Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs

Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions

Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo

Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels

Molecular control of δ-opioid receptor signalling

Molecular interactions between general anesthetics and the 5HT2B receptor.

Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric lig

N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.

Neurochemical profiles of some novel psychoactive substances

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation

Novel molecular targets of dezocine and their clinical implications

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity

Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

Structure of the human smoothened receptor bound to an antitumour agent

Structure of the human κ-opioid receptor in complex with JDTic

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

Structure-based discovery of potent and selective melatonin receptor agonists

Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.

The activities of drug inactive ingredients on biological targets

The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs

The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor

trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family

σ1 receptor ligands control a switch between passive and active threat responses