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List of works by Christian M Hedrich

"Mutation negative" familial cold autoinflammatory syndrome (FCAS) in an 8-year-old boy: clinical course and functional studies.

scientific article published on 22 July 2011

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.

scientific article published on 09 September 2009

A novel isoform of the orphan receptor RORγt suppresses IL-17 production in human T cells

scientific article published on 12 January 2012

Acrodermatitis Chronica Atrophicans.

scientific article published on 10 December 2015

Altered expression of IL-10 family cytokines in CRMO result in enhanced inflammasome activation.

scientific article

Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1β expression and release

scientific article published on 21 September 2015

Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA)

scientific article published on 15 November 2011

Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression.

scientific article

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO).

scientific article published on 23 December 2013

Autoinflammatory bone disorders.

scientific article published on 05 January 2013

Autologous stem cell transplantation in refractory paediatric Wegener's granulomatosis

scientific article published on 01 September 2011

Autosomal dominant neurohypophyseal diabetes insipidus in two families. Molecular analysis of the vasopressin-neurophysin II gene and functional studies of three missense mutations.

scientific article

Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury.

scientific article published on 05 March 2012

Bridging the gap between autoinflammation and autoimmunity

scientific article published on 26 March 2013

CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances RORγt Recruitment to the IL17A Promoter in Human T Lymphocytes ⬇️

scientific article published on September 18, 2012

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

scientific article published on 25 March 2014

Caspase-1 regulates autoinflammation in rheumatic diseases

scientific article

Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.

scientific article published on 7 February 2018

Chilblain lupus erythematosus--a review of literature.

scientific article published on 10 June 2008

Chilblain lupus erythematosus-a review of literature.

scientific article published on October 2008

Choosing the right treatment for patients with a severe course of chronic non-bacterial osteomyelitis (CNO) - pamidronate or TNF-α blockade?

scientific article

Chorioretinitis in a 7-year-old African girl, probably related to JSSc resolving to methotrexate therapy ⬇️

scientific article published on 03 February 2011

Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression.

scientific article published on 30 August 2011

Clinical and laboratory characteristics in juvenile-onset systemic lupus erythematosus across age groups

scientific article published on 31 March 2020

Clinical and laboratory phenotypes in juvenile-onset Systemic Lupus Erythematosus across ethnicities in the UK

scientific article published on 07 January 2021

Current understanding of the pathophysiology of systemic juvenile idiopathic arthritis (sJIA) and target-directed therapeutic approaches

scientific article published on 06 May 2015

DNA methylation in systemic lupus erythematosus

scientific article published on 25 November 2016

Diclofenac inhibits proliferation and matrix formation of osteoblast cells

scientific article published in January 2005

Dynamic CpG-DNA methylation of Il10 and Il19 in CD4+ T lymphocytes and macrophages: effects on tissue-specific gene expression

scientific article published on 20 December 2011

Dynamic DNA methylation patterns across the mouse and human IL10 genes during CD4+ T cell activation; influence of IL-27.

scientific article published on 16 October 2010

Early onset systemic lupus erythematosus: differential diagnoses, clinical presentation, and treatment options.

scientific article published on October 2010

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division

scientific article published on 8 July 2016

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases

scientific article published on 30 August 2011

Epigenetic patterns in systemic sclerosis and their contribution to attenuated CD70 signaling cascades

scientific article published on 10 February 2012

Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells

scientific article published on 24 April 2014

Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1.

scientific article published on 27 May 2015

Gene-function studies in systemic lupus erythematosus.

scientific article published on 04 June 2013

Good response to IL-1beta blockade by anakinra in a 23-year-old CINCA/NOMID patient without mutations in the CIAS1 gene. Cytokine profiles and functional studies

scientific article published in September 2008

Innately Adaptive or Truly Autoimmune: Is There Something Unique About Systemic Juvenile Idiopathic Arthritis?

scientific article published on 02 January 2020

Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis

scientific article published on 20 August 2019

Meningoencephalitis caused by varicella-zoster virus reactivation in a child with dominant partial interferon-gamma receptor-1 deficiency ⬇️

scientific article published on March 1, 2011

Orbital inflammation and colitis in pediatric IgG4-related disease: A case report and review of the literature

scientific article published on 03 December 2019

Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE

scientific article published in 2022

Pilot study: possible association of IL10 promoter polymorphisms with CRMO

scientific article published on 15 January 2011

Presentations and treatment of childhood scleroderma: localized scleroderma, eosinophilic fasciitis, systemic sclerosis, and graft-versus-host disease

scientific article published on 27 April 2011

SNPs talk to genes using landlines: long-range chromatin interactions link genetic risk with epigenetic patterns in Takayasu arteritis

scientific article published on 07 August 2019

Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO).

scientific article published on 21 March 2016

Serum biomarkers for the diagnosis of chronic recurrent multifocal osteomyelitis (CRMO).

scientific article published on 28 September 2015

Shaping the spectrum - From autoinflammation to autoimmunity.

scientific article published on 3 March 2016

Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling

scientific article

Still's disease in children and adults

scientific article published on 01 June 2017

TCR+CD3+CD4-CD8- effector T cells in psoriasis

scientific article published on 15 June 2017

Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis.

scientific article

Unexpectedly high incidences of chronic non-bacterial as compared to bacterial osteomyelitis in children.

scientific article

Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO) ⬇️

scientific article published on May 21, 2012

Urine and serum S100A8/A9 and S100A12 associate with active lupus nephritis and may predict response to rituximab treatment

scientific article published on 01 July 2020

[Inflammasome and gout]

scientific article published on 01 August 2016

[Osteoid osteomas of the fingers: an atypical localization? Two case reports and a review of the literature]

scientific article published on 01 March 2008

cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus

scientific article published on 25 October 2019

cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.

scientific article

cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells

scientific article published on 02 December 2013

cAMP responsive element modulator: a critical regulator of cytokine production

scientific article published on 13 March 2013

cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus

scientific article published on 24 October 2011

cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus

scientific article

cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).

scientific article published on 19 December 2011

cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease

scientific article published on 18 September 2013

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