List of works - Aldo Di Leonardo

Assignment of enolase processed pseudogene (ENO1P) to human chromosome 1 bands 1q41-->q42

scientific article published on 01 January 1996

Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells.

scientific article published on 3 February 2012

Caffeine boosts Ataluren's readthrough activity

scientific article published on 21 June 2019

Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.

scientific article published on 8 September 2005

Cytogenetic manifestations associated with the reversion, by gene amplification, at the HGPRT locus in V79 Chinese hamster cells

scientific article published on 01 June 1989

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

scientific article

DNA demethylation caused by 5-Aza-2'-deoxycytidine induces mitotic alterations and aneuploidy

scientific article

DNA topoisomerase II inhibition and gene amplification in V79/B7 cells.

scientific article published on March 1993

Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives

scientific article

Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening

scientific article published on 29 June 2016

Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway.

scientific article published on 27 October 2010

Induction of CAD gene amplification by restriction endonucleases in V79,B7 Chinese hamster cells.

scientific article published in January 1989

Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons ⬇️

scientific article published on 06 July 2020

Localization of amplified CAD genes on rearranged chromosomes of Chinese hamster cells.

scientific article

MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation

scientific article published on 01 September 2012

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

scientific article published on 04 September 2018

P14ARF: The Absence that Makes the Difference

scientific article published on 20 July 2020

Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARF tumor suppressor

scientific article published on 27 September 2018

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts.

scientific article

RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation.

scientific article

Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs

Retinoblastoma epidemiology: does the evidence matter?

scientific article published on 31 May 2007

Selection in HAT medium is not a reliable method for the study of reversion from 6-thioguanine resistance to sensitivity.

scientific article

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype.

scientific article

Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death

scientific article published on 10 April 2014

Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)

scientific article published on 06 July 2019

Targeting Nonsense: Optimization of 1,2,4-Oxadiazole TRIDs to Rescue CFTR Expression and Functionality in Cystic Fibrosis Cell Model Systems

scientific article published on 03 September 2020

The retinoblastoma paradigm revisited.

scientific article published on December 2008

Toward a rationale for the PTC124 (Ataluren) promoted readthrough of premature stop codons: a computational approach and GFP-reporter cell-based assay

scientific article

p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis.

scientific article published in February 2016

List of works by Aldo Di Leonardo

Assignment of enolase processed pseudogene (ENO1P) to human chromosome 1 bands 1q41-->q42

Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells.

Caffeine boosts Ataluren's readthrough activity

Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.

Cytogenetic manifestations associated with the reversion, by gene amplification, at the HGPRT locus in V79 Chinese hamster cells

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

DNA demethylation caused by 5-Aza-2'-deoxycytidine induces mitotic alterations and aneuploidy

DNA topoisomerase II inhibition and gene amplification in V79/B7 cells.

Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives

Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening

Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway.

Induction of CAD gene amplification by restriction endonucleases in V79,B7 Chinese hamster cells.

Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons ⬇️

Localization of amplified CAD genes on rearranged chromosomes of Chinese hamster cells.

MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

P14ARF: The Absence that Makes the Difference

Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARF tumor suppressor

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts.

RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation.

Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs

Retinoblastoma epidemiology: does the evidence matter?

Selection in HAT medium is not a reliable method for the study of reversion from 6-thioguanine resistance to sensitivity.

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype.

Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death

Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)

Targeting Nonsense: Optimization of 1,2,4-Oxadiazole TRIDs to Rescue CFTR Expression and Functionality in Cystic Fibrosis Cell Model Systems

The retinoblastoma paradigm revisited.

Toward a rationale for the PTC124 (Ataluren) promoted readthrough of premature stop codons: a computational approach and GFP-reporter cell-based assay

p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis.