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List of works by Thomas A Edwards

2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

scientific article published on 11 July 2012

A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain ⬇️

scientific article

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection ⬇️

scientific article

ATP-driven remodeling of the linker domain in the dynein motor

scientific article published on 10 October 2012

Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin

scientific article published in September 2011

Bespoke RNA recognition by Pumilios

scientific article

Cannabinoids modulate potassium current in cultured hippocampal neurons.

scientific article published in January 1993

Co-occupancy of two Pumilio molecules on a single hunchback NRE.

scientific article published on 16 April 2009

Correction: Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions ⬇️

scientific article published on 02 February 2018

Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions

scientific article published in July 2017

Crystal structure of BstYI at 1.85A resolution: a thermophilic restriction endonuclease with overlapping specificities to BamHI and BglII.

scientific article published in May 2004

Crystal structure of the SF3 helicase from adeno-associated virus type 2

scientific article

Crystal structure of the catalytic core of human DNA polymerase kappa

scientific article

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

scientific article published on 28 January 2014

Crystallization and characterization of PU.1/IRF-4/DNA ternary complex

scientific article (publication date: July 2002)

Crystallization and characterization of Smaug: a novel RNA-binding motif

scientific article published in October 2002

Disruption of six Saccharomyces cerevisiae ORFs on chromosome XII results in three lethal disruptants

scientific article published in January 2002

Erratum: Further Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions ⬇️

scientific article published on 01 February 2018

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

scientific article

Expression, purification and crystallization of the Crimean-Congo haemorrhagic fever virus nucleocapsid protein

scientific article

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology ⬇️

scientific article published on 14 November 2017

Genetic Analysis of Physcomitrella patens Identifies ABSCISIC ACID NON-RESPONSIVE, a Regulator of ABA Responses Unique to Basal Land Plants and Required for Desiccation Tolerance. ⬇️

scientific article

Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle ⬇️

scientific article (publication date: 15 October 2016)

Helix-mediated protein--protein interactions as targets for intervention using foldamers

scientific article published on 17 March 2011

Hydrocarbon constrained peptides - understanding preorganisation and binding affinity ⬇️

scientific article published on 29 February 2016

Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation ⬇️

scientific article published on 10 June 2016

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions ⬇️

scientific article published on 26 April 2017

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening ⬇️

scientific article published on 02 June 2018

Kinked  -strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL

scientific article published on 8 November 2011

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

scientific article

Model of the brain tumor-Pumilio translation repressor complex

scientific article

Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable ⬇️

scientific article

Mutagenesis mapping of the protein-protein interaction underlying FusB-type fusidic acid resistance ⬇️

scientific article

N-alkylated oligoamide alpha-helical proteomimetics

scientific article published on 18 March 2010

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization ⬇️

scientific article

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction ⬇️

scientific article published on 24 June 2009

Orthogonal functionalisation of α-helix mimetics ⬇️

scientific article published on September 2014

Probing Protein Surfaces: QSAR Analysis with Helix Mimetics.

scientific article published on 22 December 2015

Probing bunyavirus N protein oligomerisation using mass spectrometry

scientific article published on April 2014

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

scientific article published on 30 June 2021

Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

scientific article published on 7 February 2012

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions ⬇️

scientific article published on 30 January 2015

Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions ⬇️

scientific article published on 4 February 2015

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction ⬇️

scientific article

Solution Structure of the Vts1 SAM Domain in the Presence of RNA

scientific article published in March 2006

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers ⬇️

scientific article published on 30 January 2015

Structure and RNA binding of the mouse Pumilio-2 Puf domain

scientific article published in September 2009

Structure of Pumilio reveals similarity between RNA and peptide binding motifs

scientific article

Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution ⬇️

scientific article published on June 23, 2011

Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein

scientific article published in October 2012

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups ⬇️

scientific article

The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture

scientific article published in 2022

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex

scientific article published on 13 November 2018

The crystal structure of the Hazara virus nucleocapsid protein ⬇️

scientific article

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics ⬇️

scientific article published on 24 March 2016

Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase

scientific article published in October 2002

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