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List of works by Roland Kappler

Activation of the Wnt/β-catenin pathway is common in wilms tumor, but rarely through β-catenin mutation and APC promoter methylation

scientific article published on 27 September 2016

Altered expression of imprinted genes in Wilms tumors

scientific article published on 20 December 2010

An enhancer directs differential expression of the linked Mrf4 and Myf5 myogenic regulatory genes in the mouse.

scientific article published in May 2004

Analysis of the PTCH1 signaling pathway in ovarian dermoids.

scientific article

Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker.

scientific article published on 05 August 2016

Association of a CXCL9 polymorphism with pediatric Crohn's disease

scientific article published on 18 September 2007

Association of the interleukin-23 receptor gene variant rs11209026 with Crohn's disease in German children.

scientific article published on 26 February 2010

Author Correction: The landscape of genomic alterations across childhood cancers

scientific article published in Nature

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children.

scientific article

Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.

scientific article

Betulinic acid treatment promotes apoptosis in hepatoblastoma cells.

scientific article

Blocking the hedgehog pathway inhibits hepatoblastoma growth.

scientific article published in February 2009

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

scientific article

Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway

scientific article

Characteristic overexpression of the forkhead box transcription factor Foxf1 in Patched-associated tumors.

scientific article published on December 2008

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

scientific article published on 7 February 2017

Chromosomal imbalances and DNA amplifications in SV40 large T antigen-induced primitive neuroectodermal tumor cell lines of the rat.

scientific article published in August 1999

Comparative genomic in situ hybridization discloses chromosomal copy number changes in a transplanted brain tumor line of the rat (Rattus norvegicus).

scientific article

Comparative genomic in situ hybridization discloses recurrent gain of chromosome 4 in experimental gliomas of the rat.

scientific article published in January 1999

Expression of Truncated Neurokinin-1 Receptor in Childhood Neuroblastoma is Independent of Tumor Biology and Stage.

scientific article

Frequent hypermethylation of a CTCF binding site influences Wilms tumor 1 expression in Wilms tumors

scientific article published on 11 February 2014

Genetics and epigenetics of hepatoblastoma.

scientific article published on 13 July 2012

Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo.

scientific article

Hirschsprung-associated enterocolitis develops independently of NOD2 variants.

scientific article published in September 2010

IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors ⬇️

scientific article published on March 8, 2012

Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma.

scientific article published on 27 February 2014

In vivo expression of interleukin-37 reduces local and systemic inflammation in concanavalin A-induced hepatitis

scientific article published on 26 December 2011

Intestinal expression of the anti-inflammatory interleukin-1 homologue IL-37 in pediatric inflammatory bowel disease.

scientific article published on August 2014

MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma

scientific article

Molecular characterization of Patched-associated rhabdomyosarcoma.

scientific article published on July 2003

Molecular genetic characterisation of intracerebrally transplanted brain tumours.

scientific article published in January 1999

Molecular profiling of chordoma

scientific article

NOD2 mutations predict the risk for surgery in pediatric-onset Crohn's disease

scientific article published on 01 August 2010

Neutrophils express distinct RNA receptors in a non-canonical way.

scientific article

Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma

scientific article published on 2 March 2018

PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis

scientific article published on 20 September 2010

Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.

scientific article published in September 2000

Patient-derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management

scientific article published on 26 April 2016

Platelet Derived Growth Factor Has a Role in Pressure Induced Bladder Smooth Muscle Cell Hyperplasia and Acts in a Paracrine Way.

scientific article published on 6 June 2015

Pleiotropic effects of sonic hedgehog on muscle satellite cells.

scientific article published in August 2005

Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcoma

scientific article published in November 2004

RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex

scientific article published on 13 August 2012

Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients ⬇️

scientific article published on January 28, 2012

Rare occurrence of PHOX2b mutations in sporadic neuroblastomas

scientific article

Reduced body growth and excessive incisor length in insertional mutants mapping to mouse Chromosome 13.

scientific article published in September 2002

Reply to: "TERT promoter mutation during development of hepatoblastoma to hepatocellular carcinoma"

scientific article published on 05 November 2014

SP8 Promotes an Aggressive Phenotype in Hepatoblastoma via FGF8 Activation

scientific article published on 15 August 2020

Selective Methylation of CpGs at Regulatory Binding Sites Controls NNAT Expression in Wilms Tumors ⬇️

scientific article published on June 25, 2013

Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease

scientific article published on 01 November 2010

Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells.

scientific article published on 21 May 2015

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

scientific article

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

scientific article published on 15 August 2014

The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018

The p16/Cdkn2a/Ink4a gene is frequently deleted in nitrosourea-induced rat glial tumors.

scientific article

Therapeutic Innovations for Targeting Hepatoblastoma.

scientific article published on November 2016

Transcriptional activation of Hedgehog pathway components in aggressive haemangioma.

scientific article

Truncated neurokinin-1 receptor is an ubiquitous antitumor target in hepatoblastoma, and its expression is independent of tumor biology and stage

scientific article published on 20 November 2015

Tumor-associated E-cadherin mutations do not induce Wnt target gene expression, but affect E-cadherin repressors.

scientific article published on October 2004

Unbalanced overexpression of the mutant allele in murine Patched mutants

scientific article

β-Catenin mutations in 2 nested stromal epithelial tumors of the liver--a neoplasia with defective mesenchymal-epithelial transition.

scientific article published on 29 June 2012

γ-Secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets

scientific article published on 30 August 2016

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