List of works - Xuankuo Xu

A CFD Model for Predicting Protein Aggregation in Low-pH Virial Inactivation for mAb Production

scientific article published on 16 July 2020

Adaptation of the pore diffusion model to describe multi-addition batch uptake high-throughput screening experiments

article

Binary adsorption of globular proteins on ion-exchange media

scientific article published on 05 July 2009

Bioinspired supramolecular engineering of self-assembling immunofibers for high affinity binding of immunoglobulin G

scientific article published on 16 April 2018

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

scientific article published on 19 May 2020

Chromatography of proteins on charge-variant ion exchangers and implications for optimizing protein uptake rates.

scientific article

Clarification and capture of high-concentration refold pools for E. coli-based therapeutics using expanded bed adsorption chromatography.

scientific article published on 13 November 2013

Conformation Preservation of α-Helical Peptides within Supramolecular Filamentous Assemblies

scientific article published on 11 September 2017

Contributions of depth filter components to protein adsorption in bioprocessing

scientific article published on 01 May 2018

DNA RETENTION ON DEPTH FILTERS

scientific article published on 24 October 2018

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

scientific article published on 01 January 2020

Early identification of unusually clustered mutations and root causes in therapeutic antibody development

scientific article published on 06 June 2018

Emerging biomaterials for downstream manufacturing of therapeutic proteins

scientific article published on 09 March 2019

Heterogeneous glycoform separation by process chromatography: I: Monomer purification and characterization.

scientific article published on 28 May 2015

High-efficiency affinity precipitation of multiple industrial mAbs and Fc-fusion proteins from cell culture harvests using Z-ELP-E2 nanocages.

scientific article published on 21 April 2018

Hydrophobic property of cation-exchange resins affects monoclonal antibody aggregation

scientific article published on 20 September 2020

Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media.

scientific article published in February 2018

Insights in understanding aggregate formation and dissociation in cation exchange chromatography for a structurally unstable Fc-fusion protein.

scientific article published on 9 July 2016

Mechanisms of precipitate formation during the purification of an Fc-fusion protein

Model assisted comparison of Protein A resins and multi-column chromatography for capture processes

scientific article published on 27 August 2018

Model assisted process characterization and validation for a continuous two-column protein A capture process

article

One-step affinity capture and precipitation for improved purification of an industrial monoclonal antibody using Z-ELP functionalized nanocages

scientific article published on 7 October 2017

Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification

scientific article published on 02 September 2019

Shrinking-core modeling of binary chromatographic breakthrough ⬇️

scientific article published on February 16, 2011

Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization

scientific article published on 11 December 2019

Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

publication published on 01 January 2021

Virus clearance validation across continuous capture chromatography

scientific article published on 27 May 2019

List of works by Xuankuo Xu