List of works - Krzysztof Sobczak

A dimeric 2,9-diamino-1,10-phenanthroline derivative improves alternative splicing in myotonic dystrophy type 1 cell and mouse models

article

Accurate and sensitive analysis of triplet repeat expansions by capillary electrophoresis.

scientific article published in June 2005

Application of ion pair chromatography coupled with mass spectrometry to assess antisense oligonucleotides concentrations in living cells

scientific article published on 21 November 2018

Attitudes of Medical Professionals Towards Discrimination of Patients with Obesity

Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript

scientific article

CAG and CTG repeat polymorphism in exons of human genes shows distinct features at the expandable loci

scientific article published on 01 May 2007

CAG repeats mimic CUG repeats in the misregulation of alternative splicing

scientific article published on 27 July 2011

Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts

scientific article

Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy

scientific article

Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation

scientific article published on 01 September 2021

Delivering bad news in the perspective of patient rights

Delivering bad news: patient's perspective and opinions

scientific article published on 12 November 2018

Design of a "Mini" Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1.

scientific article published on 15 January 2018

Distribution of alternative untranslated regions within the mRNA of the CELF1 splicing factor affects its expression

scientific article published on 07 January 2022

Doctors’ attitudes in the situation of delivering bad news: patients’ experience and expectations

Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

scientific article published on December 2008

Experience of Patients with Obesity in Contacts with Medical Professionals [Response to Letter]

scientific article published on 03 November 2020

Experience of Polish Patients with Obesity in Contacts with Medical Professionals

scientific article published on 22 September 2020

Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1

scientific article

High frequency of recurrent mutations in BRCA1 and BRCA2 genes in Polish families with breast and ovarian cancer.

scientific article published in December 2000

Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.

scientific article published on 14 December 2017

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

scientific article

Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control

scientific article published on 21 July 2020

Intron retention induced by microsatellite expansions as a disease biomarker

scientific article published on 02 April 2018

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

scientific article

Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.

scientific article

MBNL expression in autoregulatory feedback loops.

scientific article published on 26 September 2017

MBNL proteins and their target RNAs, interaction and splicing regulation.

scientific article

MBNL splicing activity depends on RNA binding site structural context

scientific article published on 01 September 2018

MBNL1 alternative splicing isoforms play opposing roles in cancer

scientific article published on 07 September 2018

MEF2C shapes the microtranscriptome during differentiation of skeletal muscles

scientific article

Mechanistic determinants of MBNL activity

scientific article

Medical or common knowledge? Knowledge of medical professionals on obesity diagnosis criteria and treatment

Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel

scientific article

Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs

scientific article published on 15 August 2007

Muscleblind-like 2 controls the hypoxia response of cancer cells

scientific article published on 03 March 2020

Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

scientific article published on 18 January 2011

Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy

scientific article

Patients' Expectations as to Doctors' Behaviors During Appointed Visits.

scientific article published on 21 June 2016

Patterns of CAG repeat interruptions in SCA1 and SCA2 genes in relation to repeat instability

scientific article published in September 2004

Quantitative Evaluation of Toxic Polyglycine Biosynthesis and Aggregation in Cell Models Expressing Expanded CGG Repeats. ⬇️

scientific article published on 19 June 2018

Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy.

scientific article published on 12 April 2018

RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy

scientific article published on 27 November 2012

RNA structure analysis assisted by capillary electrophoresis

scientific article published in November 2002

RNA structure of trinucleotide repeats associated with human neurological diseases

scientific article

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

scientific article

Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA.

scientific article

Scaled-down genetic analysis of myotonic dystrophy type 1 and type 2.

scientific article published on 26 August 2009

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

scientific article published on 24 February 2021

Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy

scientific article

Small molecule kinase inhibitors alleviate different molecular features of myotonic dystrophy type 1.

scientific article published on 24 April 2014

Splicing biomarkers of disease severity in myotonic dystrophy

scientific article

Structural basis of microRNA length variety.

scientific article

Structural diversity of triplet repeat RNAs

scientific article published on 16 February 2010

Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design

scientific article

Structures of trinucleotide repeats in human transcripts and their functional implications.

scientific article published on October 2003

The procedure for death notification--"In Person, In Time…".

scientific article published on October 2013

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy

scientific article published on 17 February 2009

Trinucleotide repeats: triggers for genomic disorders?

scientific article published on 30 April 2010

Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target

scientific article published on 9 September 2011

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

scientific article

Unfavorable Medical Diagnosis - Oncological Patients' Experiences and Preferences

scientific article published on 21 November 2019

List of works by Krzysztof Sobczak

A dimeric 2,9-diamino-1,10-phenanthroline derivative improves alternative splicing in myotonic dystrophy type 1 cell and mouse models

Accurate and sensitive analysis of triplet repeat expansions by capillary electrophoresis.

Application of ion pair chromatography coupled with mass spectrometry to assess antisense oligonucleotides concentrations in living cells

Attitudes of Medical Professionals Towards Discrimination of Patients with Obesity

Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript

CAG and CTG repeat polymorphism in exons of human genes shows distinct features at the expandable loci

CAG repeats mimic CUG repeats in the misregulation of alternative splicing

Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts

Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy

Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation

Delivering bad news in the perspective of patient rights

Delivering bad news: patient's perspective and opinions

Design of a "Mini" Nucleic Acid Probe for Cooperative Binding of an RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1.

Distribution of alternative untranslated regions within the mRNA of the CELF1 splicing factor affects its expression

Doctors’ attitudes in the situation of delivering bad news: patients’ experience and expectations

Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1).

Experience of Patients with Obesity in Contacts with Medical Professionals [Response to Letter]

Experience of Polish Patients with Obesity in Contacts with Medical Professionals

Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1

High frequency of recurrent mutations in BRCA1 and BRCA2 genes in Polish families with breast and ovarian cancer.

Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control

Intron retention induced by microsatellite expansions as a disease biomarker

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.

MBNL expression in autoregulatory feedback loops.

MBNL proteins and their target RNAs, interaction and splicing regulation.

MBNL splicing activity depends on RNA binding site structural context

MBNL1 alternative splicing isoforms play opposing roles in cancer

MEF2C shapes the microtranscriptome during differentiation of skeletal muscles

Mechanistic determinants of MBNL activity

Medical or common knowledge? Knowledge of medical professionals on obesity diagnosis criteria and treatment

Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel

Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs

Muscleblind-like 2 controls the hypoxia response of cancer cells

Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy

Patients' Expectations as to Doctors' Behaviors During Appointed Visits.

Patterns of CAG repeat interruptions in SCA1 and SCA2 genes in relation to repeat instability

Quantitative Evaluation of Toxic Polyglycine Biosynthesis and Aggregation in Cell Models Expressing Expanded CGG Repeats. ⬇️

Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy.

RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy

RNA structure analysis assisted by capillary electrophoresis

RNA structure of trinucleotide repeats associated with human neurological diseases

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA.

Scaled-down genetic analysis of myotonic dystrophy type 1 and type 2.

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats

Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy

Small molecule kinase inhibitors alleviate different molecular features of myotonic dystrophy type 1.

Splicing biomarkers of disease severity in myotonic dystrophy

Structural basis of microRNA length variety.

Structural diversity of triplet repeat RNAs

Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design

Structures of trinucleotide repeats in human transcripts and their functional implications.

The procedure for death notification--"In Person, In Time…".

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy

Trinucleotide repeats: triggers for genomic disorders?

Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

Unfavorable Medical Diagnosis - Oncological Patients' Experiences and Preferences