List of works by Rafael Linden

A quick UPLC-MS/MS method for therapeutic drug monitoring of abiraterone and delta(4)-abiraterone (D4A) in human plasma

scientific article published on 11 July 2020

Analytical and clinical validation of a dried blood spot assay for the determination of paclitaxel using high-performance liquid chromatography-tandem mass spectrometry.

scientific article published on 4 March 2018

Association between atazanavir plasma levels and renal function in HIV-positive individuals on antiretroviral therapy with undetectable viral load

scientific article published on 28 February 2013

CYP3A4*22 is related to increased plasma levels of 4-hydroxytamoxifen and partially compensates for reduced CYP2D6 activation of tamoxifen

scientific article published on 20 April 2015

Caffeine as an indicator of human fecal contamination in the Sinos River: a preliminary study

scientific article published in May 2015

Caffeine levels as a predictor of Human mastadenovirus presence in surface waters-a case study in the Sinos River basin-Brazil.

scientific article published on 26 March 2018

Cellular effects of thirdhand tobacco smoke from smokers' homes.

scientific article published on 29 November 2017

Characterization of imatinib mesylate formulations distributed in South American countries: Determination of genotoxic impurities by UHPLC-MS/MS and dissolution profile.

scientific article published on 27 February 2018

Clinical evaluation of a dried blood spot method for determination of mycophenolic acid in renal transplant patients

scientific article published on 22 October 2013

Correlation analysis between cotinine hair concentrations from active smokers and nicotine intake and dependence

scientific article published on 01 June 2015

DBS sampling in imatinib therapeutic drug monitoring: from method development to clinical application

scientific article published on 01 January 2015

DPD functional tests in plasma, fresh saliva and dried saliva samples as predictors of 5-fluorouracil exposure and occurrence of drug-related severe toxicity

scientific article published on 04 April 2018

Determination of cannabinoids in plasma using salting-out assisted liquid-liquid extraction followed by LC-MS/MS analysis

scientific article published on 24 July 2020

Determination of docetaxel in dried blood spots by LC-MS/MS: Method development, validation and clinical application

scientific article published on 17 May 2018

Determination of irinotecan and its metabolite SN-38 in dried blood spots using high-performance liquid-chromatography with fluorescence detection

scientific article published on 4 December 2017

Determination of topiramate in dried blood spots using single-quadrupole gas chromatography-mass spectrometry after flash methylation with trimethylanilinium hydroxide.

scientific article published in February 2017

Development, validation and clinical application of a HPLC-FL method for CYP2D6 phenotyping in South Brazilian breast cancer patients

scientific article published on 18 April 2014

Dried blood spots analysis with mass spectrometry: Potentials and pitfalls in therapeutic drug monitoring.

scientific article published on 11 May 2016

Early hematological and immunological alterations in gasoline station attendants exposed to benzene

scientific article published on 17 January 2015

Ecotoxicological risk assessment due to the presence of bisphenol A and caffeine in surface waters in the Sinos River Basin - Rio Grande do Sul - Brazil

scientific article published on 08 November 2018

Effects of low-level exposure to xenobiotics present in paints on oxidative stress in workers.

scientific article published on 22 July 2010

Endogenous plasma and salivary uracil to dihydrouracil ratios and DPYD genotyping as predictors of severe fluoropyrimidine toxicity in patients with gastrointestinal malignancies

scientific article published on 8 July 2016

Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy.

scientific article published in August 2012

Environmental and biological monitoring of occupational formaldehyde exposure resulting from the use of products for hair straightening

scientific article published on 09 September 2015

Evaluation of genotoxicity and oxidative damage in painters exposed to low levels of toluene.

scientific article published on 24 February 2012

Evaluation of genotoxicity in workers exposed to low levels of formaldehyde in a furniture manufacturing facility.

scientific article published on 13 May 2015

Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity.

scientific article published in September 2008

Fast method for simultaneous quantification of tamoxifen and metabolites in dried blood spots using an entry level LC-MS/MS system.

scientific article published on 3 August 2016

First report of imatinib measurement in hair: Method development and preliminary evaluation of the relation between hair and plasma concentrations with therapeutic response in chronic myeloid leukemia

scientific article published on 03 December 2015

Improved determination of uracil and dihydrouracil in plasma after a loading oral dose of uracil using high-performance liquid chromatography with photodiode array detection and porous graphitic carbon stationary phase.

scientific article published in May 2015

Increase of global DNA methylation patterns in beauty salon workers exposed to low levels of formaldehyde

scientific article published on 12 November 2018

Influence of CYP2D6 and CYP3A4 Phenotypes, Drug Interactions, and Vitamin D Status on Tamoxifen Biotransformation

scientific article published on 4 April 2015

Monitoring imatinib plasma concentrations in chronic myeloid leukemia

scientific article

Pharmacogenetic and pharmacokinetic dose individualization of the taxane chemotherapeutic drugs paclitaxel and docetaxel

scientific article published on 22 June 2017

Pyruvate kinase activity and δ-aminolevulinic acid dehydratase activity as biomarkers of toxicity in workers exposed to lead.

scientific article published on 5 August 2012

Response surface analysis applied to the preparation of tablets containing a high concentration of vegetable spray-dried extract.

scientific article published in April 2000

Richness, coverage and concentration of heavy metals in vascular epiphytes along an urbanization gradient

scientific article

Sensitive HPLC-PDA determination of tamoxifen and its metabolites N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in human plasma

scientific article published on 13 December 2012

Simple procedure for determination of valproic acid in dried blood spots by gas chromatography-mass spectrometry

scientific article published on 02 April 2014

Simultaneous determination of cocaine, ecgonine methyl ester, benzoylecgonine, cocaethylene and norcocaine in dried blood spots by ultra-performance liquid chromatography coupled to tandem mass spectrometry

scientific article published on 23 March 2019

Simultaneous determination of fluoxetine and norfluoxetine in dried blood spots using high-performance liquid chromatography-tandem mass spectrometry

scientific article

Simultaneous determination of vancomycin and creatinine in plasma applied to volumetric absorptive microsampling devices using liquid chromatography-tandem mass spectrometry

scientific article published on 14 December 2018

Suicide attempt with acetonitrile ingestion in a nursing mother.

scientific article published on 11 May 2017

The influence on DNA damage of glycaemic parameters, oral antidiabetic drugs and polymorphisms of genes involved in the DNA repair system.

scientific article published on 22 June 2013

Thirdhand tobacco smoke: procedures to evaluate cytotoxicity in cell cultures

scientific article published on 7 June 2016

Ultra-high performance liquid chromatography tandem mass spectrometric method for the determination of tamoxifen, N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in dried blood spots--development, validation and clinical application during br

scientific article published on 29 October 2014

Voriconazole therapeutic drug monitoring: focus on safety.

scientific article published on January 2010

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