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List of works by Lewis C. Cantley

1,25(OH)2D3 increases calcium and phosphatidylinositol metabolism in differentiating cultured human keratinocytes

scientific article published on 01 February 1990

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

A Bad kinase makes good ⬇️

scientific article published on November 13, 1997

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

scientific article published on 07 October 2015

A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.

scientific article published on 3 February 2016

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

scientific article

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

scientific article published on 2 June 2013

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

scientific article published on 14 April 2013

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

scientific article

A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice

scientific article

A flattened face for membranes

scientific article published on 01 October 1998

A fluorescent reporter of AMPK activity and cellular energy stress

scientific article published on April 2011

A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis

scientific article

A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition

scientific article published on 09 December 2013

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation

scientific article

A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen

scientific article

A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms

scientific article

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

scientific article

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

scientific article

A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase

scientific article

A rapid method for determining protein kinase phosphorylation specificity

scientific article

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase

scientific article published on June 2000

A slow interconversion between active and inactive states of the (Na-K)ATPase

scientific article published on November 1976

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

scientific article published on March 1993

A wortmannin-cetuximab as a double drug

scientific article

AACR Cancer Progress Report 2015

scientific article published on October 2015

AKT/PKB signaling: navigating downstream

scientific article

AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo

scientific article published on April 2007

AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization

scientific article published on 24 March 2011

AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

scientific article

Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C ⬇️

scientific article published on January 30, 1998

Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate ⬇️

scientific article published on February 20, 1998

Activation of phosphatidylinositol 3-kinase by insulin

scientific article published on February 1990

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

scientific article published on 13 April 2015

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

scientific article

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

scientific article published on 10 July 2015

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

scientific article

Age-induced accumulation of methylmalonic acid promotes tumour progression

scientific article published on 19 August 2020

Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases

scientific article published on 24 August 2010

Akt/protein kinase B promotes organ growth in transgenic mice

scientific article

Altered metabolism in cancer

scientific article

Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha

scientific article

Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment

scientific article

An integrated vector system for cellular studies of phage display-derived peptides

scientific article

Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation

scientific article

Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts.

scientific article

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

scientific article

BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity

scientific article published on 20 March 2014

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

scientific article

Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis

scientific article (publication date: May 2009)

Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds ⬇️

scientific article published on May 5, 1993

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

scientific article published on December 2005

Breathless cancer cells get fat on glutamine ⬇️

scientific article published on January 3, 2012

Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation

scientific article

Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation

scientific article

Cancer Discovery at One Year: The Editors' Interim Analysis ⬇️

scientific article published on January 1, 2012

Cancer metabolism: fatty acid oxidation in the limelight ⬇️

scientific article published on February 28, 2013

Cancer's Fuel Choice: New Flavors for a Picky Eater

scientific article

Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar

scientific article published on 31 January 2013

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article published on June 2010

Cell biology. Ancient sensor for ancient drug

scientific article published in May 2012

Cell regulation

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

scientific article

Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations

scientific article

Characterization of KRAS rearrangements in metastatic prostate cancer

scientific article published on June 2011

Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking

scientific article

Characterization of nucleotide binding sites on chloroplast coupling factor 1

scientific article (publication date: July 1975)

Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation ⬇️

scientific article (publication date: 13 January 1976)

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis

scientific article

Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis

scientific article

Chemoprevention meets glucose control

scientific article published on September 2010

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

scholarly article

Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms

scientific article published on December 2010

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

scientific article

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

scientific article published on 22 August 2012

Computational prediction of protein-protein interactions

scientific article published on January 2015

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

scientific article published on October 1997

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

scientific article published on 11 June 2007

Covalent Reactions of Wortmannin under Physiological Conditions

D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate

scientific article published on 01 December 1996

Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis

scholarly article

Delta endotoxin inhibits Rb+ uptake, lowers cytoplasmic pH and inhibits a K+-ATPase in Manduca sexta CHE cells

scientific article

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors

scientific article

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

scientific article

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

scientific article

Determination of the specific substrate sequence motifs of protein kinase C isozymes

scientific article published on January 1997

Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates

scientific article

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε

scientific article

Development of an intracellularly acting inhibitory peptide selective for PKN.

scientific article

Dietary fructose improves intestinal cell survival and nutrient absorption

scientific article published in 2021

Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2 ⬇️

scientific article published on 01 October 1998

Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

scientific article published on August 2005

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

scientific article published on November 2011

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

scientific article

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

scientific article published on 01 November 2019

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src

scientific article published on 9 November 2015

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

scientific article

Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney

scientific article published in October 1996

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

scientific article

Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol

scientific article

Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium

scientific article

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

scientific article

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

scientific article published on 12 June 2013

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

scientific article

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

scientific article

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol

scientific article

Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis

scientific article published in March 2007

Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons

scientific article

Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells

scientific article published in November 1997

FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS

scientific article published on 01 April 2021

Fate of a bioactive fluorescent wortmannin derivative in cells

scientific article published on 8 November 2007

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

scientific journal article

Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism

scientific article published on August 2013

Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1

scientific article published on July 1, 1975

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

scientific article published on 06 September 2013

Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain

scientific article

Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity

scientific article

Genetic selection for enhanced serine metabolism in cancer development

scientific article published on 15 November 2011

Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?

scientific article

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

scientific article published on 27 March 2013

Glutathione reduces cytoplasmic vanadate mechanism and physiological implications ⬇️

scientific article published on April 17, 1980

Growth factor and oncogene influences on cell growth regulation

scientific article

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis

scientific article

Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association ⬇️

scientific article published on January 9, 2002

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

scientific article published on 21 April 2013

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

scientific article

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif

scientific article published on July 1997

High-fructose corn syrup enhances intestinal tumor growth in mice

scientific article published on 01 March 2019

Human erythrocyte anion exchange site characterised using a fluorescent probe

scientific article published on November 29, 1979

Human pluripotent stem cells decouple respiration from energy production

scientific article

Idelalisib--a PI3Kδ inhibitor for B-cell cancers

scientific article published on March 2014

Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients

scientific article published on February 2013

Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids

scientific article published on 28 October 2020

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

scientific article

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

scientific article published in February 2016

Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src

scientific article published on October 1995

Identification of small molecule inhibitors of anthrax lethal factor

scientific article

Identification of small molecule inhibitors of pyruvate kinase M2

scientific article

Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

scientific article

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway

scientific article

In vivo near-infrared fluorescence imaging of osteoblastic activity

scientific article

In-gel stable isotope labeling for relative quantification using mass spectrometry

Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice

scientific article

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

scientific article

Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line

scientific article published on December 1983

Influence of threonine metabolism on S-adenosylmethionine and histone methylation

scientific article published on November 2012

Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains

scientific article

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways

scientific article

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

scientific article published on August 1994

Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer

scientific article published on 03 March 2020

Interactions between transport inhibitors at the anion binding sites of the band 3 dimer ⬇️

scientific article published on September 1, 1981

Interferon regulatory factor-3 is an in vivo target of DNA-PK.

scientific article

Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase

scientific article published on August 1991

Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton

scientific article published on October 1993

Interpreting sequences from mastodon and T. rex.

scientific article

Introduction

Investigation of quercetin binding sites on chloroplast coupling factor 1

scientific article (publication date: 13 January 1976)

Ion transport systems sequenced

Isolation of a potent (Na-K)ATPase inhibitor from striated muscle

scientific article

IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling

scientific article

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells ⬇️

scientific article published on July 1, 1997

LOCATION OF BINDING SITES ON THE (Na.K)-ATPase FOR FLUORESCEIN-5'-ISOTHIOCYANATE AND OUABAIN

scientific article published on 01 January 1982

Large-scale characterization of HeLa cell nuclear phosphoproteins

scientific article

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

scientific article published on 22 June 2020

Lin28 enhances tissue repair by reprogramming cellular metabolism

scientific article

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

scientific article published on 08 February 2024

Lipid Research Picks Up Speed on the Slopes of Taos

scientific article published on 01 April 2002

Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C

scientific article

Location of the stilbenedisulfonate binding site of the human erythrocyte anion-exchange system by resonance energy transfer

scientific article published on October 16, 1979

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

scholarly article

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

scientific article

Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites ⬇️

scientific article published on September 29, 1981

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer

scientific article published on 28 May 2013

Metabolic flux and the regulation of mammalian cell growth

scientific article published on October 2011

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival

scientific article

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

scientific article published on 8 November 2012

Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma

scientific article

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

scientific article published on 17 May 2013

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

scientific article published on 03 July 2013

Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms

scientific article published on 30 September 2005

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase

scientific article

Molecular phylogenetics of mastodon and Tyrannosaurus rex.

scientific article

Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B.

scientific article

NRF2 regulates serine biosynthesis in non-small cell lung cancer

scientific article

Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation

scientific article published on 22 July 2003

Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation

scientific article published on January 2009

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

scientific article

Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha

scientific article

Overview of the Alliance for Cellular Signaling

scientific article

PD-142 ErbB-3 mediates PI3K activity in gefitinib-sensitive non-smallcell lung cancer cell lines

PHGDH amplification and altered glucose metabolism in human melanoma

scientific article published on 28 October 2011

PI3K drives the de novo synthesis of coenzyme A from vitamin B5

scientific article published on 27 July 2022

PI3K enters beta-testing

scientific article published on September 2008

PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer

scientific article published on 23 February 2009

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

scientific article

PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients

scientific article

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

scientific article published on 10 June 2013

Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.

scientific article

Pathways for phosphoinositide synthesis

scientific article

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

scientific article

Peptide libraries: at the crossroads of proteomics and bioinformatics

scientific article

Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma

scientific article published on 21 October 2013

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis

scientific article published on 09 October 2009

Phosphatidylinositol 3-kinase

scientific article published on August 1994

Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis ⬇️

scientific article published on November 1, 2001

Phosphatidylinositol metabolism and polyoma-mediated transformation

scientific article published on June 1986

Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction

scientific article published on February 1994

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals ⬇️

scientific article published on April 1, 1998

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

scientific article

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

scientific article published on January 2016

Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling ⬇️

scientific article published on September 11, 1998

Phosphoinositide 3-kinase and the regulation of cell growth

scientific article

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

scientific article

Phosphoinositide 3-kinase in immunological systems

scientific article

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit ⬇️

scientific article published on May 5, 1993

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

scholarly article

Phosphoinositide binding domains: embracing 3-phosphate

scientific article

Phosphoinositide kinases

scientific article published on December 1990

Phosphoinositide metabolism and the control of cell proliferation

scientific article

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9

scientific article published on 15 April 2013

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

scientific article

Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences

scientific article

Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation

scientific article published on 03 October 2013

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

scientific article

Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn

scientific article

Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling ⬇️

scientific article published on September 22, 2003

Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer

scientific article

Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer

scientific article published on 30 October 2020

Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry

scientific article

Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation

scientific article published on 02 May 2013

Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries

scientific article published on 2 August 2011

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

scientific article

PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis

scientific article

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article

Pyruvate kinase M2 is a phosphotyrosine-binding protein

scientific article

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

scientific article

Reaction of (sodium(1+)-potassium(1+) ion)-activated ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site ⬇️

scientific article published on February 7, 1978

Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).

scientific article published on October 1993

Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate

scientific article published on January 1998

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

scholarly article

Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase

Regulation of mTORC1 by PI3K signaling

scientific article

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

scientific article

Rewiring of glycolysis in cancer cell metabolism

scientific article published on 7 November 2010

Rheb fills a GAP between TSC and TOR.

scientific article published on November 2003

SH2 domain specificity and activity modified by a single residue

scientific article

SIRT6 puts cancer metabolism in the driver's seat.

scientific article

SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells ⬇️

scientific article published on February 23, 1998

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

scientific article

Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.

scientific article published on June 1997

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

scientific article published on 25 November 2012

Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase

scholarly article

Slow self-activation enhances the potency of viridin prodrugs

scientific article published on 17 July 2008

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

scientific article

Somatic mutations of PIK3R1 promote gliomagenesis

scientific article

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

scientific article

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

scientific article

Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer

scientific article published on 24 March 2014

Stem cell metabolism in tissue development and aging

scientific article published on June 2013

Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

scientific article published on October 1996

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

scientific article published on 23 October 2009

Sugar free, cancer free?

scientific article published on October 2012

Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy

scientific article published on 9 September 2015

Synthesis and activity of C11-modified wortmannin probes for PI3 kinase

scientific article published in May 2005

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

scientific article published on 6 March 2012

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

scientific article

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

scientific article published on April 2007

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

scientific article

Targeting a common collaborator in cancer development

scientific article

Targeting cancer vulnerabilities with high-dose vitamin C

scientific article published on 01 May 2019

Targeting metabolic scavenging in pancreatic cancer

scientific article published on 28 October 2013

Targeting the PI3K signaling pathway in cancer

scientific article

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

scientific article published on October 2003

The APL paradigm and the "co-clinical trial" project

scientific article published on July 2011

The C2 domain of PKCdelta is a phosphotyrosine binding domain

scientific article

The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

scientific article

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

scientific article

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer

scientific article published on 08 June 2020

The LKB1 tumor suppressor negatively regulates mTOR signaling

scientific article

The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape

scientific article

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

scientific article

The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility

scientific article

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity ⬇️

scientific article (publication date: 26 December 1997)

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

scientific article

The antiproliferative cytostatic effects of a self-activating viridin prodrug

scientific article

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

scientific article

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

scientific article (publication date: August 2006)

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

scientific article

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

scientific article

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

scientific article

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance

scientific article published on 5 February 2007

The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation

scientific article published on August 2003

The phosphoinositide 3-kinase pathway

scientific article

The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling

scientific article published on 8 June 2010

The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump

scientific article published on 01 January 1984

The role of phosphoinositide 3-kinase lipid products in cell function

scientific article

The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors

scientific article published on July 2006

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

scientific article

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

scientific article

Toward a better understanding of folate metabolism in health and disease

scientific article published on 26 December 2018

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

scientific article

Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking

article

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

scientific article

Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

scientific journal article

Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

article

Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases

scientific article

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

scientific article

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

scientific article published on 8 March 2011

Understanding the Warburg effect: the metabolic requirements of cell proliferation

scientific article

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

scientific article

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

scientific article

Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes

scientific article published in April 2004

Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer

scientific article published on 20 July 2011

Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

scientific article

Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side ⬇️

scientific article published on April 6, 1978

Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis

scientific article

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

scientific article

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway

scientific article

p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake

scientific article

p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation

scientific article

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