List of works - Jana Janockova

Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity.

scientific article published on 14 July 2016

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

scientific article published on 26 September 2016

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment

scientific article published on 30 May 2016

In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers

scientific article published on 01 December 2019

Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds.

scientific article published on 8 May 2015

Interaction of cholinesterase modulators with DNA and their cytotoxic activity.

scientific article published in December 2013

Investigation of New Orexin 2 Receptor Modulators Using and In Vitro Methods

scientific article published on 09 November 2018

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

scientific article published in September 2017

N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy

scientific article published on 01 January 2019

New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds

scientific article published on 6 February 2016

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.

scientific article

Novel cholinesterase modulators and their ability to interact with DNA.

scientific article published on 17 June 2013

Orexin supplementation in narcolepsy treatment: A review

scientific article published on 14 November 2018

Profiling donepezil template into multipotent hybrids with antioxidant properties.

scientific article published in December 2018

Proliferation inhibition of novel diphenylamine derivatives

scientific article published on 02 November 2018

Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro.

scientific article published on 11 January 2018

Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives

scientific article published on 26 June 2019

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.

scientific article published on 14 May 2016

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy

scientific article published on 01 December 2019

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment

scientific article published on 27 December 2016

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase

scientific article published on 08 February 2019

Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors.