List of works - Gabriel C. Lander

A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality

scientific article published on 15 November 2018

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

scientific article

A test-bed for optimizing high-resolution single particle reconstructions

scientific article

A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy.

scientific article

Ab initio maximum likelihood reconstruction from cryo electron microscopy images of an infectious virion of the tailed bacteriophage P22 and maximum likelihood versions of Fourier Shell Correlation appropriate for measuring resolution of spherical o

scientific article

Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV.

scientific article published on 9 October 2017

AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex

scientific article published on 01 June 2020

An allosteric network in spastin couples multiple activities required for microtubule severing

scientific article published on 08 July 2019

Appion: an integrated, database-driven pipeline to facilitate EM image processing

scientific article (publication date: April 2009)

Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

scientific article

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.

scientific article published on 8 January 2016

Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing

scientific article published on 01 April 2020

Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

scientific article published on 01 April 2018

Automated cryoEM data acquisition and analysis of 284742 particles of GroEL.

scientific article

Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM.

scientific article published on September 2008

Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM.

scientific article published on November 2006

Complete subunit architecture of the proteasome regulatory particle ⬇️

scientific article published on January 11, 2012

Conformational ensemble of the human TRPV3 ion channel

scientific article published in Nature Communications

Conformational switching of the 26S proteasome enables substrate degradation

scientific article

Cryo-EM structure of a mitochondrial calcium uniporter

scientific article published on 28 June 2018

Cryo-electron microscopy structure of the TRPV2 ion channel

scientific article

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

scientific article published on 7 February 2018

Crystal Structure of Group II Chaperonin in the Open State

scientific article

Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM

scientific article published on 07 October 2019

DNA bending-induced phase transition of encapsidated genome in phage λ.

scientific article published on 28 February 2013

Development of bacteriophage p22 as a platform for molecular display: genetic and chemical modifications of the procapsid exterior surface

article

Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase.

scientific article published on 27 May 2009

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

scientific article published on 26 February 2020

Functional annotation of the Arabidopsis genome using controlled vocabularies

scientific article (publication date: June 2004)

Genomic and functional analysis of Vibrio phage SIO-2 reveals novel insights into ecology and evolution of marine siphoviruses

scientific article published on 9 January 2012

Go hybrid: EM, crystallography, and beyond ⬇️

scientific article published on July 24, 2012

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

scientific article

High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM

scientific article published on 04 March 2019

Isolation of yeast complex IV in native lipid nanodiscs

scientific article

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex

scientific article

Molecular architecture of human polycomb repressive complex 2

scientific article published in 2012

Molecular glue CELMoD compounds are regulators of cereblon conformation

scientific article published on 4 November 2022

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases

scientific article

Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22

scientific article

Setting the dynein motor in motion: New insights from electron tomography

scientific article published on 08 July 2019

Site-specific labeling of proteins for electron microscopy.

scientific article published on 23 September 2015

Small Terminase Couples Viral DNA Binding to Genome-Packaging ATPase Activity ⬇️

scientific article published on 8 August 2012

Solid-to-fluid-like DNA transition in viruses facilitates infection

scientific article

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation

scientific article published on 28 November 2019

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

scientific article published on 20 May 2020

Structural organization of the dynein-dynactin complex bound to microtubules

scientific article

Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex

scientific article published on March 2017

Structure of the cold- and menthol-sensing ion channel TRPM8.

scientific article

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

scientific article

Structures of the RNA-guided surveillance complex from a bacterial immune system

scientific article

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

scientific article

Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus.

scientific article

The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit.

scientific article published on June 2009

The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.

scientific article

The Structure of an Infectious P22 Virion Shows the Signal for Headful DNA Packaging

scientific article

The YΦ motif defines the structure-activity relationships of human 20S proteasome activators

scientific article published on 09 March 2022

The molecular principles governing the activity and functional diversity of AAA+ proteins

scientific article published on 21 November 2019

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.

scientific article published on 10 January 2018

The proteasome under the microscope: the regulatory particle in focus

scientific article

Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex.

scientific article

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.

scientific article

VIPERdb2: an enhanced and web API enabled relational database for structural virology

scientific article

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

scientific article published on 20 August 2019

What's the Key to Unlocking the Proteasome's Gate?

scientific article published in December 2016

List of works by Gabriel C. Lander

A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

A test-bed for optimizing high-resolution single particle reconstructions

A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy.

Ab initio maximum likelihood reconstruction from cryo electron microscopy images of an infectious virion of the tailed bacteriophage P22 and maximum likelihood versions of Fourier Shell Correlation appropriate for measuring resolution of spherical o

Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV.

AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex

An allosteric network in spastin couples multiple activities required for microtubule severing

Appion: an integrated, database-driven pipeline to facilitate EM image processing

Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.

Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing

Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

Automated cryoEM data acquisition and analysis of 284742 particles of GroEL.

Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM.

Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM.

Complete subunit architecture of the proteasome regulatory particle ⬇️

Conformational ensemble of the human TRPV3 ion channel

Conformational switching of the 26S proteasome enables substrate degradation

Cryo-EM structure of a mitochondrial calcium uniporter

Cryo-electron microscopy structure of the TRPV2 ion channel

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

Crystal Structure of Group II Chaperonin in the Open State

Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM

DNA bending-induced phase transition of encapsidated genome in phage λ.

Development of bacteriophage p22 as a platform for molecular display: genetic and chemical modifications of the procapsid exterior surface

Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase.

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

Functional annotation of the Arabidopsis genome using controlled vocabularies

Genomic and functional analysis of Vibrio phage SIO-2 reveals novel insights into ecology and evolution of marine siphoviruses

Go hybrid: EM, crystallography, and beyond ⬇️

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM

Isolation of yeast complex IV in native lipid nanodiscs

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex

Molecular architecture of human polycomb repressive complex 2

Molecular glue CELMoD compounds are regulators of cereblon conformation

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases

Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22

Setting the dynein motor in motion: New insights from electron tomography

Site-specific labeling of proteins for electron microscopy.

Small Terminase Couples Viral DNA Binding to Genome-Packaging ATPase Activity ⬇️

Solid-to-fluid-like DNA transition in viruses facilitates infection

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

Structural organization of the dynein-dynactin complex bound to microtubules

Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex

Structure of the cold- and menthol-sensing ion channel TRPM8.

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

Structures of the RNA-guided surveillance complex from a bacterial immune system

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus.

The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit.

The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.

The Structure of an Infectious P22 Virion Shows the Signal for Headful DNA Packaging

The YΦ motif defines the structure-activity relationships of human 20S proteasome activators

The molecular principles governing the activity and functional diversity of AAA+ proteins

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.

The proteasome under the microscope: the regulatory particle in focus

Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex.

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.

VIPERdb2: an enhanced and web API enabled relational database for structural virology

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

What's the Key to Unlocking the Proteasome's Gate?