List of works by Steven Niederer

A Biophysical Systems Approach to Identifying the Pathways of Acute and Chronic Doxorubicin Mitochondrial Cardiotoxicity

scientific article

A Computational Model of Cardiac Electromechanics

article

A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges

scientific article published on 11 August 2015

A comparison of left ventricular endocardial, multisite, and multipolar epicardial cardiac resynchronization: an acute haemodynamic and electroanatomical study

scientific article published on 12 February 2014

A comparison of the different features of quadripolar left ventricular pacing leads to deliver cardiac resynchronization therapy

scientific article published on 23 August 2017

A computational pipeline for quantification of mouse myocardial stiffness parameters

scientific article

A mathematical model of the slow force response to stretch in rat ventricular myocytes.

scientific article published on 16 March 2007

A meta-analysis of cardiac electrophysiology computational models.

scientific article published on 12 January 2009

A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes

scientific article published on 6 April 2017

A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity

scientific article published on 29 August 2017

A prospective evaluation of cardiovascular magnetic resonance measures of dyssynchrony in the prediction of response to cardiac resynchronization therapy

scientific article published on August 2014

A quantitative analysis of cardiac myocyte relaxation: a simulation study.

scientific article published on 9 December 2005

A simulated single ventilator/dual patient ventilation strategy for acute respiratory distress syndrome during the COVID-19 pandemic

scientific article published on 24 August 2020

A two-variable model robust to pacemaker behaviour for the dynamics of the cardiac action potential.

scientific article

An Automatic Data Assimilation Framework for Patient-Specific Myocardial Mechanical Parameter Estimation

An accurate, fast and robust method to generate patient-specific cubic Hermite meshes

scientific article published on 06 July 2011

An analysis of deformation-dependent electromechanical coupling in the mouse heart

scientific article published on 21 May 2012

An automatic service for the personalization of ventricular cardiac meshes

scientific article published on 11 December 2013

An improved numerical method for strong coupling of excitation and contraction models in the heart

scientific article published on 10 August 2007

Analysis of lead placement optimization metrics in cardiac resynchronization therapy with computational modelling.

scientific article published in December 2016

Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation.

scientific article published on January 2016

At the heart of computational modelling.

scientific article published on 23 January 2012

Beneficial Effect on Cardiac Resynchronization From Left Ventricular Endocardial Pacing Is Mediated by Early Access to High Conduction Velocity Tissue

scientific article published in October 2015

Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice

scientific article published on 19 March 2013

Biophysical Modeling to Determine the Optimization of Left Ventricular Pacing Site and AV/VV Delays in the Acute and Chronic Phase of Cardiac Resynchronization Therapy.

scientific article published on 25 November 2016

Biophysical modeling to simulate the response to multisite left ventricular stimulation using a quadripolar pacing lead

scientific article published on 31 October 2011

Cardiac CT assessment of tissue thickness at the ostium of the left atrial appendage predicts acute success of radiofrequency ablation.

scientific article published on 21 September 2017

Cardiac computational modeling of ventricular tachycardia and cardiac resynchronization therapy: a clinical perspective.

scientific article published on 17 February 2017

Comprehensive use of cardiac computed tomography to guide left ventricular lead placement in cardiac resynchronization therapy.

scientific article published on 4 May 2017

Computational Modeling for Cardiac Resynchronization Therapy.

scientific article published on 11 January 2018

Computational biology of cardiac myocytes: proposed standards for the physiome.

scientific article

Computational fluid dynamic modelling to determine the hemodynamic effects of implanting a transcatheter mitral valve within the left ventricle.

scientific article published on 13 November 2017

Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

scientific article published in 2021

Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle

scientific article

Computational modelling of cardiac electrophysiology: explanation of the variability of results from different numerical solvers

scientific article published on 28 February 2012

Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart.

scientific article published on June 2009

Coupling multi-physics models to cardiac mechanics.

scientific article

CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels.

scientific article published on 15 November 2015

Current concepts relating coronary flow, myocardial perfusion and metabolism in left bundle branch block and cardiac resynchronisation therapy.

scientific article

Delayed trans-septal activation results in comparable hemodynamic effect of left ventricular and biventricular endocardial pacing: insights from electroanatomical mapping.

scientific article published on 7 March 2014

Detection of focal source and arrhythmogenic substrate from body surface potentials to guide atrial fibrillation ablation

scientific article published on 21 March 2022

Effects of Epicardial and Endocardial Cardiac Resynchronization Therapy on Coronary Flow: Insights From Wave Intensity Analysis.

scientific article published on 17 December 2015

Efficient computation of electrograms and ECGs in human whole heart simulations using a reaction-eikonal model.

scientific article published on October 2017

Efficient computational methods for strongly coupled cardiac electromechanics.

scientific article published on 7 February 2011

Factors influencing left ventricular outflow tract obstruction following a mitral valve-in-valve or valve-in-ring procedure, part 1.

scientific article published on October 2015

Genotype-Phenotype Map Characteristics of an In silico Heart Cell

scientific article (publication date: 2011)

High-throughput functional curation of cellular electrophysiology models

scientific article published on 15 June 2011

Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes

scientific article published on 19 February 2020

Image-Based Personalization of Cardiac Anatomy for Coupled Electromechanical Modeling.

scientific article published on 30 September 2015

Images as drivers of progress in cardiac computational modelling.

scientific article

Improved identifiability of myocardial material parameters by an energy-based cost function.

scientific article

Improvement of Right Ventricular Hemodynamics with Left Ventricular Endocardial Pacing during Cardiac Resynchronization Therapy

scientific article published on 22 March 2016

Improving the stability of cardiac mechanical simulations.

scientific article published on 2 December 2014

In silico identification of potential calcium dynamics and sarcomere targets for recovering left ventricular function in rat heart failure with preserved ejection fraction

scientific article published on 06 December 2021

Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development.

scientific article

Integrating multi-scale data to create a virtual physiological mouse heart

scientific article

Integration of different cardiac electrophysiological models into a single simulation pipeline

scientific article published in May 2012

Inter-model consistency and complementarity: learning from ex-vivo imaging and electrophysiological data towards an integrated understanding of cardiac physiology.

scientific article

Intra-Atrial Conduction Delay Revealed by Multisite Incremental Atrial Pacing is an Independent Marker of Remodeling in Human Atrial Fibrillation.

scientific article published on September 2017

Is computational modeling adding value for understanding the Heart?

scientific article published in July 2016

Left ventricular outflow obstruction predicts increase in systolic pressure gradients and blood residence time after transcatheter mitral valve replacement

scientific article published in Scientific Reports

Length-dependent tension in the failing heart and the efficacy of cardiac resynchronization therapy

scientific article published on 14 October 2010

Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte

scientific article

Mechanistic insights into the benefits of multisite pacing in cardiac resynchronization therapy: The importance of electrical substrate and rate of left ventricular activation

scientific article published on 09 July 2015

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

scientific article published on 6 June 2017

Modelling and measuring electromechanical coupling in the rat heart.

scientific article published on 13 February 2009

Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design

scientific article published on 01 April 2022

Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths

scientific article published on 7 September 2017

Optimized Left Ventricular Endocardial Stimulation Is Superior to Optimized Epicardial Stimulation in Ischemic Patients With Poor Response to Cardiac Resynchronization Therapy: A Combined Magnetic Resonance Imaging, Electroanatomic Contact Mapping, a

scientific article published on 01 December 2016

Personalization of cubic Hermite meshes for efficient biomechanical simulations

scientific article published on 01 January 2010

Personalized Models of Human Atrial Electrophysiology Derived From Endocardial Electrograms.

scientific article published on 30 May 2016

Quality metrics for high order meshes: analysis of the mechanical simulation of the heart beat

scientific article published on 3 December 2012

Quantifying inter-species differences in contractile function through biophysical modelling

scientific article

Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer.

scientific article published on 15 November 2015

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression

article

Regulation of ion gradients across myocardial ischemic border zones: a biophysical modelling analysis.

scientific article

Restitution slope is principally determined by steady-state action potential duration.

scientific article

Simulating human cardiac electrophysiology on clinical time-scales

scientific article

Simultaneous display of multiple three-dimensional electrophysiological datasets (dot mapping).

scientific article

Species-dependent adaptation of the cardiac Na+/K+ pump kinetics to the intracellular Na+ concentration.

scientific article published on 31 October 2014

Standardised Framework for Quantitative Analysis of Fibrillation Dynamics

scientific article published on 13 November 2019

The calcium-frequency response in the rat ventricular myocyte: an experimental and modelling study.

scientific article

The effect of activation rate on left atrial bipolar voltage in patients with paroxysmal atrial fibrillation.

scientific article published on 22 June 2017

The estimation of patient-specific cardiac diastolic functions from clinical measurements.

scientific article published on 16 October 2012

The impact of beat-to-beat variability in optimising the acute hemodynamic response in cardiac resynchronisation therapy

scientific article

The impact of wall thickness and curvature on wall stress in patient-specific electromechanical models of the left atrium

scientific article published on 04 December 2019

The relative role of patient physiology and device optimisation in cardiac resynchronisation therapy: A computational modelling study

scientific article

The role of myocardial wall thickness in atrial arrhythmogenesis

scientific article published on 31 May 2016

The role of the Frank-Starling law in the transduction of cellular work to whole organ pump function: a computational modeling analysis

scientific article

Three-dimensional atrial wall thickness maps to inform catheter ablation procedures for atrial fibrillation

scientific article published on 4 April 2015

Towards causally cohesive genotype-phenotype modelling for characterization of the soft-tissue mechanics of the heart in normal and pathological geometries.

scientific article

Transcatheter mitral valve replacement in mitral annulus calcification - "The art of computer simulation".

scientific article published on 4 January 2018

Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction

scientific article published on 14 March 2008

Using cardiac ionic cell models to interpret clinical data

scientific article published on 07 October 2020

Using physiologically based models for clinical translation: predictive modelling, data interpretation or something in-between?

scientific article

Vagal modulation of dispersion of repolarisation in the rabbit heart

scientific article

Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour ⬇️

scientific article published in December 2015

Verification of cardiac tissue electrophysiology simulators using an N-version benchmark.

scientific article published on November 2011

Paulina is supported by:

About Paulina

Help