List of works - Mario Alberto Flores-Valdez

A quantitative model for dermal infection and oedema in BALB/c mice pinna

scientific article (publication date: 12 December 2016)

Advanced hydrogels for treatment of diabetes

scientific article published on 18 July 2019

An opportunity to compare the effects of BCG-Moreau and BCG-Russia in Brazil

scientific article published on 01 September 2018

BCG Vaccination Prevents Reactivation of Latent Lymphatic Murine Tuberculosis Independently of CD4 T Cells

scientific article published on 21 March 2019

BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines

scientific article published on 12 March 2020

BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice

scientific article published on 24 August 2018

Can immunization with Bacillus Calmette-Guérin be improved for prevention or therapy and elimination of chronic Mycobacterium tuberculosis infection?

scientific article published on 01 December 2019

Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia

scientific article published on 04 October 2019

Erratum: Author Correction: BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines

scientific article published on 20 October 2020

Evaluation of the immunogenic capability of the BCG strains BCGΔBCG1419c and BCGΔBCG1416c in a three-dimensional human lung tissue model.

scientific article published on 20 February 2018

Expression of non-replicating persistence associated genes of Mycobacterium bovis in lymph nodes from skin test-reactor cattle.

scientific article

Global reemergence of tuberculosis: are host defense peptides an option to ameliorate disease burden?

scientific article

How Can We Diagnose Tuberculosis More Effectively?

scholarly article

Identification of immunodominant antigens of Mycobacterium bovis by expression library immunization.

scientific article

Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence.

scientific article

LeuO antagonizes H-NS and StpA-dependent repression in Salmonella enterica ompS1.

scientific article published in October 2007

Macrophage infection with combinations of BCG mutants reduces induction of TNF-α, IL-6, IL-1β and increases IL-4

scientific article published on 25 January 2019

Matrix metalloproteases and their association to tuberculosis

scientific article published on 01 September 2010

Mice continue to be a good model for preliminary assessment of tuberculosis vaccine candidates.

scientific article published on 20 October 2016

Modulation of autophagy as a strategy for development of new vaccine candidates against tuberculosis

scientific article published on 13 March 2018

Modulation of cAMP metabolism in Mycobacterium tuberculosis and its effect on host infection

scientific article published on 10 April 2010

Molecular findings and approaches spotlighting Mycobacterium bovis persistence in cattle

scientific article published on 18 February 2009

Multiantigenic subunitary vaccines against tuberculosis in clinical trials: Where do we stand and where do we need to go?

scientific article published on 6 April 2016

Mycobacterium bovis DNA detection in colostrum as a potential indicator of vaccination effectiveness against bovine tuberculosis

scientific article published on 20 February 2013

Mycobacterium tuberculosis modulates its cell surface via an oligopeptide permease (Opp) transport system

scientific article

Negative osmoregulation of the Salmonella ompS1 porin gene independently of OmpR in an hns background

scientific article

New potential biomarkers to assess efficacy of protection afforded by vaccine candidates against tuberculosis

scientific article published on 20 February 2019

OmpR phosphorylation regulates ompS1 expression by differentially controlling the use of promoters.

scientific article

Overexpression of DosR in Mycobacterium tuberculosis does not affect aerobic replication in vitro or in murine macrophages

scholarly article by Mario Alberto Flores-Valdez et al published 24 May 2014 in Annals of Microbiology

Overexpression of the celA1 gene in BCG modifies surface pellicle, glucosamine content in biofilms, and affects in vivo replication

scientific article published on 01 October 2020

Preclinical evaluation of tuberculosis vaccine candidates: Is it time to harmonize study design and readouts for prioritizing their development?

scientific article published on 14 December 2020

Proteomic characterization of a second-generation version of the BCGΔBCG1419c vaccine candidate by means of Electrospray-ionization quadrupole time-of-flight mass spectrometry

scientific article published on 17 November 2020

Recent mouse models and vaccine candidates for preventing chronic/latent tuberculosis infection and its reactivation.

scientific article published in August 2017

The BCGΔBCG1419c Vaccine Candidate Reduces Lung Pathology, IL-6, TNF-α, and IL-10 During Chronic TB Infection.

scientific article

The BCGΔBCG1419c strain, which produces more pellicle in vitro, improves control of chronic tuberculosis in vivo.

scientific article published on 18 August 2016

The Cyclic Di-GMP Phosphodiesterase Gene Rv1357c/BCG1419c Affects BCG Pellicle Production and In Vivo Maintenance.

scientific article published on February 2015

The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG.

scientific article

The synthetic cathelicidin HHC-10 inhibits Mycobacterium bovis BCG in vitro and in C57BL/6 mice.

scientific article

Transcriptional and mycolic acids profiling in Mycobacterium bovis BCG in vitro show an effect for c-di-GMP and overlap between dormancy and biofilms

scientific article published on 13 March 2020

Transcriptional portrait of M. bovis BCG during biofilm production shows genes differentially expressed during intercellular aggregation and substrate attachment

scientific article published on 28 July 2020

Uncovering the hidden: complexity and strategies for diagnosing latent tuberculosis.

scientific article published on 24 October 2017

Vaccination of guinea pigs with BCGΔBCG1419c transiently reduces hematogenous spread of M. tuberculosis to the spleen

scientific article published on 01 December 2018

Vaccination of mice with recombinant bacille Calmette-Guérin harboring Rv1357c protects similarly to native BCG.

scientific article

Vaccines Directed Against Microorganisms or Their Products Present During Biofilm Lifestyle: Can We Make a Translation as a Broad Biological Model to Tuberculosis?

scientific article published on 21 January 2016

[Biological, clinical and epidemiological aspects of latent tuberculosis]

scientific article published on 01 January 2010

List of works by Mario Alberto Flores-Valdez

A quantitative model for dermal infection and oedema in BALB/c mice pinna

Advanced hydrogels for treatment of diabetes

An opportunity to compare the effects of BCG-Moreau and BCG-Russia in Brazil

BCG Vaccination Prevents Reactivation of Latent Lymphatic Murine Tuberculosis Independently of CD4 T Cells

BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines

BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice

Can immunization with Bacillus Calmette-Guérin be improved for prevention or therapy and elimination of chronic Mycobacterium tuberculosis infection?

Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia

Erratum: Author Correction: BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines

Evaluation of the immunogenic capability of the BCG strains BCGΔBCG1419c and BCGΔBCG1416c in a three-dimensional human lung tissue model.

Expression of non-replicating persistence associated genes of Mycobacterium bovis in lymph nodes from skin test-reactor cattle.

Global reemergence of tuberculosis: are host defense peptides an option to ameliorate disease burden?

How Can We Diagnose Tuberculosis More Effectively?

Identification of immunodominant antigens of Mycobacterium bovis by expression library immunization.

Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence.

LeuO antagonizes H-NS and StpA-dependent repression in Salmonella enterica ompS1.

Macrophage infection with combinations of BCG mutants reduces induction of TNF-α, IL-6, IL-1β and increases IL-4

Matrix metalloproteases and their association to tuberculosis

Mice continue to be a good model for preliminary assessment of tuberculosis vaccine candidates.

Modulation of autophagy as a strategy for development of new vaccine candidates against tuberculosis

Modulation of cAMP metabolism in Mycobacterium tuberculosis and its effect on host infection

Molecular findings and approaches spotlighting Mycobacterium bovis persistence in cattle

Multiantigenic subunitary vaccines against tuberculosis in clinical trials: Where do we stand and where do we need to go?

Mycobacterium bovis DNA detection in colostrum as a potential indicator of vaccination effectiveness against bovine tuberculosis

Mycobacterium tuberculosis modulates its cell surface via an oligopeptide permease (Opp) transport system

Negative osmoregulation of the Salmonella ompS1 porin gene independently of OmpR in an hns background

New potential biomarkers to assess efficacy of protection afforded by vaccine candidates against tuberculosis

OmpR phosphorylation regulates ompS1 expression by differentially controlling the use of promoters.

Overexpression of DosR in Mycobacterium tuberculosis does not affect aerobic replication in vitro or in murine macrophages

Overexpression of the celA1 gene in BCG modifies surface pellicle, glucosamine content in biofilms, and affects in vivo replication

Preclinical evaluation of tuberculosis vaccine candidates: Is it time to harmonize study design and readouts for prioritizing their development?

Proteomic characterization of a second-generation version of the BCGΔBCG1419c vaccine candidate by means of Electrospray-ionization quadrupole time-of-flight mass spectrometry

Recent mouse models and vaccine candidates for preventing chronic/latent tuberculosis infection and its reactivation.

The BCGΔBCG1419c Vaccine Candidate Reduces Lung Pathology, IL-6, TNF-α, and IL-10 During Chronic TB Infection.

The BCGΔBCG1419c strain, which produces more pellicle in vitro, improves control of chronic tuberculosis in vivo.

The Cyclic Di-GMP Phosphodiesterase Gene Rv1357c/BCG1419c Affects BCG Pellicle Production and In Vivo Maintenance.

The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG.

The synthetic cathelicidin HHC-10 inhibits Mycobacterium bovis BCG in vitro and in C57BL/6 mice.

Transcriptional and mycolic acids profiling in Mycobacterium bovis BCG in vitro show an effect for c-di-GMP and overlap between dormancy and biofilms

Transcriptional portrait of M. bovis BCG during biofilm production shows genes differentially expressed during intercellular aggregation and substrate attachment

Uncovering the hidden: complexity and strategies for diagnosing latent tuberculosis.

Vaccination of guinea pigs with BCGΔBCG1419c transiently reduces hematogenous spread of M. tuberculosis to the spleen

Vaccination of mice with recombinant bacille Calmette-Guérin harboring Rv1357c protects similarly to native BCG.

Vaccines Directed Against Microorganisms or Their Products Present During Biofilm Lifestyle: Can We Make a Translation as a Broad Biological Model to Tuberculosis?

[Biological, clinical and epidemiological aspects of latent tuberculosis]

[Extensively drug-resistant tuberculosis (XDR-TB): successful therapies used in the clinic to the disease]