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List of works by Bruce N Cronstein

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1 ⬇️

scientific article published on November 1, 1992

A personal journey from the joint to the heart.

scientific article published on 13 August 2010

A prize for the foreign-born.

scientific article

A public-private partnership: the New York University-Health and Hospitals Corporation Clinical and Translational Science Institute.

scientific article published on June 2012

A tribute to Gerald Weissmann (1930-2019)

scientific article published on 01 November 2019

A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux.

scientific article

Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements

scientific article

Activation of adenosine A(2A) receptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

scientific article published on July 2013

Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3.

scientific article

Adenosine A 2A Receptor Activation Prevents Wear Particle–Induced Osteolysis ⬇️

scientific article published on May 23, 2012

Adenosine A(2A) receptor ligation inhibits osteoclast formation.

scientific article

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis

scientific article published on 19 June 2006

Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism.

scientific article

Adenosine A1 receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling.

scientific article

Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function.

scientific article

Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.

scientific article published in January 2003

Adenosine A2A receptor (A2AR) activation triggers Akt signaling and enhances nuclear localization of β-catenin in osteoblasts

scientific article published on 13 March 2019

Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance

scientific article published on 08 June 2013

Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species-mediated mitochondrial injury

scientific article published on 13 February 2020

Adenosine A2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis.

scientific article published on 2 February 2018

Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.

scientific article

Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel).

scientific article

Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.

scientific article published on February 2013

Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis.

scientific article

Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes

scientific article published on 11 May 2021

Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signalin

scientific article published on 14 September 2007

Adenosine A2A receptor plays an important role in radiation-induced dermal injury

scientific article

Adenosine A2A receptor promotes collagen type III synthesis via β-catenin activation in human dermal fibroblasts.

scientific article published on 5 September 2016

Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development.

scientific article

Adenosine A2B receptors play an important role in bone homeostasis.

scientific article published on 11 June 2016

Adenosine A2a Receptor Blockade Diminishes Wnt/β-Catenin Signaling in a Murine Model of Bleomycin-Induced Dermal Fibrosis.

scientific article published on 28 June 2017

Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases

scientific article published on 10 November 2016

Adenosine in fibrosis.

scientific article

Adenosine in inflammatory joint diseases.

scientific article

Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway

scientific article published on January 2013

Adenosine metabolism, immunity and joint health.

scientific article published on 7 February 2018

Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.

scientific article published on June 2002

Adenosine receptor activation ameliorates type 1 diabetes.

scientific article published on 3 April 2007

Adenosine receptors and fibrosis: a translational review ⬇️

scientific article published on October 3, 2011

Adenosine receptors in wound healing, fibrosis and angiogenesis.

scientific article published on January 2009

Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.

scientific article published on 16 May 2013

Adenosine signaling contributes to ethanol-induced fatty liver in mice.

scientific article published on 16 February 2009

Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats

scientific article published on 15 May 2019

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

scientific article

Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.

scientific article

Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis.

scientific article published on 13 February 2018

Biosimilars: how similar?

scientific article published on March 2014

Biosimilars: the debate continues.

scientific article

Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression

scientific article published on 05 December 2018

Bone Tissue Engineering in the Growing Calvarium Using Dipyridamole-Coated 3D Printed Bioceramic Scaffolds: Construct Optimization and Effects to Cranial Suture Patency

scientific article published on 19 November 2019

Bone regeneration in critical bone defects using three-dimensionally printed β-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2.

scientific article published on 29 October 2015

Bovine thrombin and the clinical consequence of antibody development

scientific article published on 01 January 2008

Brief Report: Methotrexate Prevents Wear Particle-Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2A Receptor.

scientific article published on December 2014

CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism.

scientific article published on 8 May 2009

Caffeine, a drug for all seasons.

scientific article

Cholesterol 27-hydroxylase but not apolipoprotein apoE contributes to A2A adenosine receptor stimulated reverse cholesterol transport

scientific article published on February 2012

Clinical trial development for biosimilars

scientific article

Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout.

scientific article published on June 2012

Come from away: Best practices in mini-sabbaticals for the development of young investigators: a White Paper by the SEQUIN (mini-Sabbatical Evaluation and QUality ImprovemeNt) Group

scientific article published on 01 February 2019

Correlation of the conformation of a modified ribonuclease octapeptide, homologous to peptide T, with its ability to induce CD4-dependent monocyte chemotaxis

scientific article published on 01 October 1992

Designing and implementing INTREPID, an intensive program in translational research methodologies for new investigators

scientific article

Dipyridamole Augments Three-Dimensionally Printed Bioactive Ceramic Scaffolds to Regenerate Craniofacial Bone

scientific article published on 01 May 2019

Dipyridamole enhances osteogenesis of three-dimensionally printed bioactive ceramic scaffolds in calvarial defects.

scientific article published on 21 November 2017

Dipyridamole-loaded 3D-printed bioceramic scaffolds stimulate pediatric bone regeneration in vivo without disruption of craniofacial growth through facial maturity

scientific article published on 05 December 2019

Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2.

scientific article

Do elevated red blood cell methotrexate polyglutamate levels predict methotrexate efficacy?

scientific article published on 20 March 2007

Do genetic variations in the adenosine pathway affect patient response to methotrexate?

scientific article published on 01 December 2006

Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.

scientific article

Ecto-5'-nucleotidase (CD73) regulates bone formation and remodeling during intramembranous bone repair in aging mice

scientific article

Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis.

scientific article published on June 2008

Effects of Acute Colchicine Administration Prior to Percutaneous Coronary Intervention: COLCHICINE-PCI Randomized Trial

scientific article published on 16 April 2020

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression.

scientific article

Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis.

scientific article published on December 2013

Fibroblasts from methotrexate-sensitive mice accumulate methotrexate polyglutamates but those from methotrexate-resistant mice do not.

scientific article published on 04 March 2013

Folic acid and folinic acid supplements and methotrexate therapy: comment on the article by Morgan et al.

scientific article published in April 2005

Form and functional repair of long bone using 3D-printed bioactive scaffolds

scientific article published on 24 August 2018

Gerald Weissmann: Inflammation in rheumatic disease

scientific article published on 22 January 2020

Gout: forgotten therapy for a common disease

scientific article published on 01 March 2005

Greater number of narcotic analgesic prescriptions for osteoarthritis is associated with falls and fractures in elderly adults.

scientific article published on March 2013

Growth Hormone Control of Hepatic Lipid Metabolism

scientific article published on 27 September 2016

How does methotrexate suppress inflammation?

scientific article published on September 1, 2010

Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1.

scientific article

Immune Responses Associated With Perioperative Exposure and Reexposure to Topical Bovine Thrombin Do Not Impair Hemostasis

article

Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages ⬇️

scientific article published on November 1, 2001

Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts.

scientific article

Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells.

scientific article

Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages.

scientific article

Interferon-gamma inhibits adenosine A2A receptor function in hepatic stellate cells by STAT1-mediated repression of adenylyl cyclase ⬇️

scientific article published on October 1, 2010

Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritis.

scientific article published on January 2007

Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing

scientific article published on 18 June 2018

Mechanisms of action of methotrexate

scientific article

Mechanistic Aspects of Inflammation and Clinical Management of Inflammation in Acute Gouty Arthritis ⬇️

scientific article published on January 1, 2013

Methotrexate BAFFles anti-drug antibodies

scientific article published on 01 September 2018

Methotrexate and its mechanisms of action in inflammatory arthritis

scientific article published on 17 February 2020

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides ⬇️

scientific article published on January 15, 1998

Methotrexate in rheumatoid arthritis

scientific article published on 01 January 2007

Methotrexate mechanism in treatment of rheumatoid arthritis

scientific article published on 03 August 2018

Methotrexate--the anchor drug--an introduction

scientific article published on 01 September 2010

Methylxanthines and Inflammatory Cells ⬇️

scientific article published on January 1, 2011

Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis

scientific article published on 8 August 2016

Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation

scientific article

Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis.

scientific article published on 9 October 2015

Outcomes related to methotrexate dose and route of administration in patients with rheumatoid arthritis: a systematic literature review

scientific article

Pharmacogenetics in the rheumatic diseases

scientific article published on 01 January 2006

Pharmacogenetics in the rheumatic diseases, from prêt-à-porter to haute couture

scientific article published on 01 January 2006

Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine

scientific article published on 8 May 2008

Pharmacological blockade of adenosine A2A receptors diminishes scarring

scientific article

Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease

scientific article published on 23 June 2009

Profiling Clinical Research Activity at an Academic Medical Center by Using Institutional Databases: Content Analysis

scientific article published on 24 August 2020

Promotion of Wound Healing by an Agonist of Adenosine A2A Receptor Is Dependent on Tissue Plasminogen Activator.

scientific article published in December 2015

Purinergic signaling in scarring

scientific article

Regulation of bone and cartilage by adenosine signaling.

scientific article published on 29 July 2016

Regulation of foam cells by adenosine.

scientific article

Regulation of inflammation by adenosine.

scientific article published on 8 April 2013

Repair of Critical-Sized Long Bone Defects Using Dipyridamole-Augmented 3D-Printed Bioactive Ceramic Scaffolds

scientific article published on 08 August 2019

Requirements for T lymphocyte migration in explanted lymph nodes.

scientific article

Response to RFP: "rigorous test of intelligent design".

scientific article published in December 2005

Restraint stress fails to modulate cutaneous hypersensitivity responses in mice lacking the adenosine A1 receptor.

scientific article

Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat ad

scientific article published on 01 March 2000

Rheumatoid arthritis: GWAS or TMI?

scientific article published on 27 October 2009

Rolofylline, an adenosine A1 receptor antagonist, inhibits osteoclast differentiation as an inverse agonist ⬇️

scientific article published on November 1, 2013

Signaling of the Purinergic System in the Joint

scientific article published on 01 January 2019

Signaling pathways involving adenosine A2A and A2B receptors in wound healing and fibrosis.

scientific article published on 4 February 2016

Something old, something new--colchicine in the 21st century

scientific article published on 01 November 2009

Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis.

scientific article

Teaching Targeted Drug Discovery and Development to Healthcare Professionals

scientific article published on 7 November 2017

Teaching Translational Research to Medical Students: The New York University School of Medicine's Master's of Science in Clinical Investigation Dual-Degree Program

scientific article published on 13 September 2015

Tenofovir Causes Bone Loss via Decreased Bone Formation and Increased Bone Resorption, Which Can Be Counteracted by Dipyridamole in Mice

scientific article published on 25 February 2019

Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells.

scientific article published on October 2003

The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling ⬇️

scientific article published on August 1, 2013

The Effect of A2A Adenosine Receptor Activation on C-C Chemokine Receptor 7 Expression in Human THP1 Macrophages During Inflammation ⬇️

scientific article published on April 1, 2012

The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

scientific article published on 14 April 2018

The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.

scientific article

The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice

scientific article published on 01 May 2007

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

scientific article

The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin.

scientific article published on 16 November 2017

The benefits and drawbacks of biosimilars

scientific article published on October 2015

The role of 3D printing in treating craniomaxillofacial congenital anomalies

scientific article published on 20 May 2018

The roles of adenosine and adenosine receptors in bone remodeling

scientific article published on June 1, 2011

Three dimensionally printed bioactive ceramic scaffold osseoconduction across critical-sized mandibular defects

scientific article published on 17 November 2017

Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism.

scientific article

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2018

scientific article published on 02 February 2019

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

scientific article published on 29 October 2019

Update on gout: pathophysiology and potential treatments.

scientific article published on December 2007

Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors.

scientific article

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