List of works - James Briscoe

The mechanisms of Hedgehog signalling and its roles in development and disease

scientific article published on 30 May 2013

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

scientific journal article

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

scientific journal article

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

scientific article published on 11 November 1993

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

scientific journal article

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

scientific article

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

scientific article

The transcriptional control of trunk neural crest induction, survival, and delamination

scientific journal article

Neural crest development is regulated by the transcription factor Sox9.

scientific article published in October 2003

Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube

scientific article published on January 2012

The interpretation of morphogen gradients

scientific article

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

scientific article

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube

scientific article published in June 2001

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

scientific article published on April 1995

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

scientific article

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

scientific article

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

scientific article

SOX9 induces and maintains neural stem cells

scientific journal article

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

scientific journal article

Gli proteins and the control of spinal-cord patterning

scientific article

Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome

scientific article

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

scientific article published on February 1997

Oncogenicity of the developmental transcription factor Sox9.

scientific article

In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity

scientific article

The specification of neuronal identity by graded Sonic Hedgehog signalling.

scientific article published on 01 June 1999

The floor plate: multiple cells, multiple signals

scientific article

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

scientific article

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog

scientific article

Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback

scientific article

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

scientific article

Morphogen rules: design principles of gradient-mediated embryo patterning

scientific article

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube

scientific article published on January 1, 1997

A fluorescent reporter of caspase activity for live imaging

scientific article

Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites.

scientific article

Otx2 regulates subtype specification and neurogenesis in the midbrain

scientific journal article

The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity

scientific article published on 01 February 2006

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

scientific article

Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube

scientific article published on January 2008

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

scientific article

The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling

scientific article

Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

scientific article

Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling

scientific article published on 30 April 2015

Coordination of progenitor specification and growth in mouse and chick spinal cord

scientific article

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

scientific journal article

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

scientific article

Morphogen interpretation: the transcriptional logic of neural tube patterning

scientific article published on 29 May 2013

Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

scientific journal article

Developmental pattern formation: insights from physics and biology

scientific article published on October 2012

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

scientific article published in March 2009

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin

scientific journal article

List of works by James Briscoe

The mechanisms of Hedgehog signalling and its roles in development and disease

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

The transcriptional control of trunk neural crest induction, survival, and delamination

Neural crest development is regulated by the transcription factor Sox9.

Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube

The interpretation of morphogen gradients

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

SOX9 induces and maintains neural stem cells

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

Gli proteins and the control of spinal-cord patterning

Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Oncogenicity of the developmental transcription factor Sox9.

In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity

The specification of neuronal identity by graded Sonic Hedgehog signalling.

The floor plate: multiple cells, multiple signals

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog

Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

Morphogen rules: design principles of gradient-mediated embryo patterning

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube

A fluorescent reporter of caspase activity for live imaging

Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites.

Otx2 regulates subtype specification and neurogenesis in the midbrain

The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling

Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling

Coordination of progenitor specification and growth in mouse and chick spinal cord

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

Morphogen interpretation: the transcriptional logic of neural tube patterning

Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

Developmental pattern formation: insights from physics and biology

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin