List of works - James Briscoe

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

scientific article published on February 1997

A fluorescent reporter of caspase activity for live imaging

scientific article

A focus on scope

scientific article published on 26 March 2019

A gene regulatory motif that generates oscillatory or multiway switch outputs

scientific article published on 12 December 2012

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

scientific article

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube

scientific article published in June 2001

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

scientific journal article

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

scientific article published on April 1995

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

scientific article published in March 2009

A shared transcriptional code orchestrates temporal patterning of the central nervous system

scientific article published on 12 November 2021

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

scientific article

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis

scientific article

Agonizing Hedgehog

scientific article published on 01 January 2006

An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates

scientific article

An inducible transgene expression system for zebrafish and chick

scientific article published on May 2013

An interview with Olivier Pourquie

scientific article published in February 2010

An intuitive graphical visualization technique for the interrogation of transcriptome data

scientific article

An ode to the Node: 10 years in the life of a community blog

scientific article published on 06 July 2020

Anterior Hox Genes Interact with Components of the Neural Crest Specification Network to Induce Neural Crest Fates ⬇️

scientific article published on May 1, 2011

Applying an adaptive watershed to the tissue cell quantification during T-cell migration and embryonic development.

scientific article published in January 2010

Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord

scientific article published on 7 December 2011

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

scientific article

Coordination of progenitor specification and growth in mouse and chick spinal cord

scientific article

Decoding of position in the developing neural tube from antiparallel morphogen gradients.

scientific article

Developing new associations

scientific article published on 05 March 2020

Development-on-chip: in vitro neural tube patterning with a microfluidic device

scientific article

Developmental Pattern Formation in Phases.

scientific article published on October 2015

Developmental pattern formation: insights from physics and biology

scientific article published on October 2012

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

scientific article

Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube

scientific article

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

scientific article

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog

scientific article

ERK1/2 signalling dynamics promote neural differentiation by regulating the polycomb repressive complex

article published in 2019

Epithelial organisation revealed by a network of cellular contacts

scientific article published on 8 November 2011

Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback

scientific article

Establishing neuronal circuitry: Hox genes make the connection

scientific article published in July 2004

Establishing neuronal diversity in the spinal cord: a time and a place

scientific article published on 25 November 2019

Floor Plate Patterning of Ventral Cell Types: Ventral Patterning

scholarly article published 2009

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

scientific article

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

scientific article

G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

scientific article published on 6 February 2018

Gene expression dysregulation domains are not a specific feature of Down syndrome

scientific article published on 06 June 2019

Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube

scientific article published on January 2012

Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

scientific journal article

Genetics of system biology ⬇️

scientific article published on December 27, 2012

Gli proteins and the control of spinal-cord patterning

scientific article

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube

scientific article published on January 1, 1997

Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs

scientific article published in February 2005

Hedgehog signaling: measuring ligand concentrations with receptor ratios

scientific article published in October 2004

Hedgehog threads to spread

scientific article published in November 2013

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

scientific journal article

Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning

scientific article published in June 2005

Human axial progenitors generate trunk neural crest cells in vitro

scientific article published on 10 August 2018

In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity

scientific article

Inclusion and diversity in developmental biology: introducing the Node Network

scientific article published on 23 January 2020

Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome

scientific article

Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

scientific article

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain

scientific article published on July 2009

Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity

scientific article

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

scientific article

Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches ⬇️

scientific article

JAKs and STATs branch out.

scientific article published in September 1996

JAKs, STATs and signal transduction in response to the interferons and other cytokines

scientific article published on February 1996

Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord.

scientific article published on July 2011

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

scientific article

Let there be preLights: one year on

scientific article published on 22 February 2019

Limbs made to measure

scientific article

Local retinoic acid signaling directs emergence of the extraocular muscle functional unit

scientific article published on 17 November 2020

Looking at neurodevelopment through a big data lens

scientific article published on 01 September 2020

Making a grade: Sonic Hedgehog signalling and the control of neural cell fate

scientific article

Mathematical models help explain experimental data. Response to 'Transcriptional interpretation of Shh morphogen signaling: computational modeling validates empirically established models'.

scientific article published in May 2016

Memory functions reveal structural properties of gene regulatory networks.

scientific article published on 22 February 2018

Morphogen interpretation: concentration, time, competence, and signaling dynamics

scientific article published on 20 March 2017

Morphogen interpretation: the transcriptional logic of neural tube patterning

scientific article published on 29 May 2013

Morphogen rules: design principles of gradient-mediated embryo patterning

scientific article

Morphogens, modeling and patterning the neural tube: an interview with James Briscoe

scientific article

Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development

scientific article

Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs

scientific article published on 9 March 2016

Neural crest development is regulated by the transcription factor Sox9.

scientific article published in October 2003

Neuronal differentiation affects tissue mechanics and progenitor arrangement in the vertebrate neuroepithelium

Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium

scientific article published on 04 December 2019

New Year PlanS

scientific article published on 04 January 2019

Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling

scientific article published on 30 April 2015

Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics

scientific article published in February 2018

Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics

Oncogenicity of the developmental transcription factor Sox9.

scientific article

Otx2 regulates subtype specification and neurogenesis in the midbrain

scientific journal article

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

scientific article

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

scientific journal article

Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling. ⬇️

scientific article published on 4 February 2013

Please allow me to introduce myself

Primary cilia and graded Sonic Hedgehog signaling

scientific article published on 04 April 2012

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms

scientific article

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

article

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.

scientific article

Regionalization of the nervous system requires axial allocation prior to neural lineage commitment

Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites.

scientific article

Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube

scientific article published on January 2008

Retinoid Acid Specifies Neuronal Identity through Graded Expression of Ascl1.

scientific article published in April 2013

Retinoid acid specifies neuronal identity through graded expression of Ascl1.

scientific article published on 14 February 2013

SOX9 induces and maintains neural stem cells

scientific journal article

SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors

scientific article

Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube

scientific article

Signal transduction. Just another signalling pathway.

scientific article published on November 1994

Singapore signalling: the 2012 hedgehog pathway cocktail

scientific article published on 29 June 2012

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

scientific article published on 27 March 2019

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features

scientific article published on 05 August 2021

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

scientific article

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

scientific article published on 12 May 2022

Species-specific pace of development is associated with differences in protein stability

scientific article

TRF2-independent chromosome end protection during pluripotency

scientific article published on 25 November 2020

Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube.

scientific article published on 5 March 2013

Temporal dynamics of patterning by morphogen gradients

scientific article published on 10 July 2009

The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition

scientific article published on 11 November 2020

The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity

scientific article published on 01 February 2006

The antiviral response to gamma interferon

scientific article published on September 2002

The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling

scientific article

The floor plate: multiple cells, multiple signals

scientific article

The generation and diversification of spinal motor neurons: signals and responses

scientific article published in September 2004

The interpretation of morphogen gradients

scientific article

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

scientific journal article

The mechanisms of Hedgehog signalling and its roles in development and disease

scientific article published on 30 May 2013

The physics of development 100years after D'Arcy Thompson's "On Growth and Form".

scientific article

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

scientific article

The route to spinal cord cell types: a tale of signals and switches

scientific article published on 27 March 2015

The specification of neuronal identity by graded Sonic Hedgehog signalling.

scientific article

The transcriptional control of trunk neural crest induction, survival, and delamination

scientific journal article

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin

scientific journal article

The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling

scientific article published on April 2013

Thomas M. Jessell (1951-2019)

scientific article published on 24 May 2019

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

scientific journal article

Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome

scientific article published on 17 October 2013

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates

scientific article

What does time mean in development?

article

Zooming into 2021

scientific article published on 07 January 2021

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.

scientific article published on 16 April 2018

List of works by James Briscoe

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

A fluorescent reporter of caspase activity for live imaging

A focus on scope

A gene regulatory motif that generates oscillatory or multiway switch outputs

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

A shared transcriptional code orchestrates temporal patterning of the central nervous system

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis

Agonizing Hedgehog

An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates

An inducible transgene expression system for zebrafish and chick

An interview with Olivier Pourquie

An intuitive graphical visualization technique for the interrogation of transcriptome data

An ode to the Node: 10 years in the life of a community blog

Anterior Hox Genes Interact with Components of the Neural Crest Specification Network to Induce Neural Crest Fates ⬇️

Applying an adaptive watershed to the tissue cell quantification during T-cell migration and embryonic development.

Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

Coordination of progenitor specification and growth in mouse and chick spinal cord

Decoding of position in the developing neural tube from antiparallel morphogen gradients.

Developing new associations

Development-on-chip: in vitro neural tube patterning with a microfluidic device

Developmental Pattern Formation in Phases.

Developmental pattern formation: insights from physics and biology

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog

ERK1/2 signalling dynamics promote neural differentiation by regulating the polycomb repressive complex

Epithelial organisation revealed by a network of cellular contacts

Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback

Establishing neuronal circuitry: Hox genes make the connection

Establishing neuronal diversity in the spinal cord: a time and a place

Floor Plate Patterning of Ventral Cell Types: Ventral Patterning

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

Gene expression dysregulation domains are not a specific feature of Down syndrome

Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube

Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

Genetics of system biology ⬇️

Gli proteins and the control of spinal-cord patterning

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube

Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs

Hedgehog signaling: measuring ligand concentrations with receptor ratios

Hedgehog threads to spread

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning

Human axial progenitors generate trunk neural crest cells in vitro

In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity

Inclusion and diversity in developmental biology: introducing the Node Network

Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome

Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain

Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches ⬇️

JAKs and STATs branch out.

JAKs, STATs and signal transduction in response to the interferons and other cytokines

Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord.

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

Let there be preLights: one year on

Limbs made to measure

Local retinoic acid signaling directs emergence of the extraocular muscle functional unit

Looking at neurodevelopment through a big data lens

Making a grade: Sonic Hedgehog signalling and the control of neural cell fate

Mathematical models help explain experimental data. Response to 'Transcriptional interpretation of Shh morphogen signaling: computational modeling validates empirically established models'.

Memory functions reveal structural properties of gene regulatory networks.

Morphogen interpretation: concentration, time, competence, and signaling dynamics

Morphogen interpretation: the transcriptional logic of neural tube patterning

Morphogen rules: design principles of gradient-mediated embryo patterning

Morphogens, modeling and patterning the neural tube: an interview with James Briscoe

Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development

Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs

Neural crest development is regulated by the transcription factor Sox9.