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List of works by Amedeo Columbano

A long term, non-tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis

scientific article published on February 2017

Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP.

scientific article published in October 2004

Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model.

scientific article published on 24 September 2007

Animal Models: A Useful Tool to Unveil Metabolic Changes in Hepatocellular Carcinoma

scientific article published on 10 November 2020

Cell death: current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo.

scientific article

Cell proliferation in rat kidney induced by 1,2-dibromoethane

scientific article published on 01 June 1987

Ciprofibrate and triiodothyronine do not suppress in vivo induction of placental glutathione S-transferase expression in rat hepatocytes

scientific article published on 01 April 2000

Clustered protocadherins methylation alterations in cancer

scientific article published on 09 July 2019

Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss

scientific article published on 3 March 2016

Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis

scientific article published on 03 October 2015

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

scientific article published on 23 December 2019

Dietary orotic acid, a new selective growth stimulus for carcinogen altered hepatocytes in rat.

scientific article published on July 1982

Different effects of the liver mitogens triiodo-thyronine and ciprofibrate on the development of rat hepatocellular carcinoma

scientific article published on January 2003

Differential effects of choline administration on liver microsomes of female and male rats

scientific article published on 01 April 1978

Distinct Mechanisms Are Responsible for Nrf2-Keap1 Pathway Activation at Different Stages of Rat Hepatocarcinogenesis

scientific article published on 16 August 2020

Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis

scientific article

Estimation of a significance threshold for epigenome-wide association studies

scientific article

Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis.

scientific article published on February 1987

GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease

scientific article

Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia

scientific article published in November 2005

Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice

scientific article

Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation.

scientific article published on 24 June 2011

Genetic mapping and expression analysis of the murine DNA ligase I gene

article

Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene

article

Genotoxic and non-genotoxic activities of 2,4- and 2,6-diaminotoluene, as evaluated in Fischer-344 rat liver

scientific article

Hexose monophosphate shunt and cholesterogenesis in lead-induced kidney hyperplasia

scientific article published on 01 January 1987

High Frequency of β-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist

scientific article published on 08 September 2018

In vivo replication of carcinogen-modified rat liver DNA: increased susceptibility of O6-methylguanine compared to N-7-methylguanine in replicated DNA to S1-nuclease

scientific article published on 01 July 1980

Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.

scientific article published on January 2007

Induction of autophagy promotes the growth of early preneoplastic rat liver nodules

scientific article published on 31 December 2015

Induction of hepatocyte proliferation by retinoic acid.

scientific article

Induction of pancreatic acinar cell proliferation by thyroid hormone.

scientific article published in June 2005

Induction of rat liver glutathione transferase subunit 7 by lead nitrate

scientific article published in August 1989

Involvement of DNA polymerase beta in proliferation of rat liver induced by lead nitrate or partial hepatectomy

scientific article published on 01 September 1992

Lead nitrate induces certain biochemical properties characteristic of hepatocyte nodules

scientific article published in October 1986

Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-kappaB and AP-1 or with expression of tumor necrosis factor alpha.

scientific article published in March 1997

Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine

scientific article published on 01 September 1987

Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats

scientific article

Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli.

scientific article published in November 2002

Met as a therapeutic target in HCC: facts and hopes.

scientific article

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

scientific article published on 7 April 2016

MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer.

scientific article published on 16 December 2011

MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).

scientific article published on 18 November 2013

MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?

scientific article published on 26 December 2012

Mitogenesis by ligands of nuclear receptors: an attractive model for the study of the molecular mechanisms implicated in liver growth.

scientific article

Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases

scientific article published on 12 October 2020

Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis.

scientific article published on 22 April 2015

Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor alpha

scientific article published on 01 June 1996

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration

scientific article published on 29 April 2020

Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation.

scientific article published on 11 February 2008

Progenitor-derived hepatocellular carcinoma model in the rat.

scientific article

Proteomic characterization of early changes induced by triiodothyronine in rat liver

scientific journal article

Regulation of poly(ADP-ribose) polymerase mRNA levels during compensatory and mitogen-induced growth of rat liver

scientific article published on 01 June 1990

Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes.

scientific article published in July 2001

Reply to: "YAP in tumorigenesis: Friend or foe?"

scientific article published on 17 February 2015

Requirement of cell proliferation for the induction of presumptive preneoplastic lesions in rat liver by a single dose of 1,2-dimethylhydrazine

scientific article published on 01 November 1980

Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression.

scientific article published on 16 January 2012

Stimulation of DNA synthesis after a single administration of cadmium nitrate.

scientific article

Stimulation of DNA synthesis by rat plasma following in vivo treatment with three liver mitogens

scientific article published on 01 January 1992

Stimulation of rat liver growth by a single administration of lead nitrate

scientific article published on 01 September 1982

Susceptibility of dimethylnitrosamine induced O6-methylguanine containing regions in in vivo replicated, hybrid rat liver DNA towards S1 nuclease

scientific article published on 01 October 1980

T3/TRs axis in hepatocellular carcinoma: new concepts for an old pair

scientific article

TRbeta is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells.

scientific article published on July 2010

The Dual Roles of NRF2 in Cancer.

scientific article published on 2 June 2016

The Thyromimetic KB2115 (Eprotirome) Induces Rat Hepatocyte Proliferation.

scientific article

The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival

scientific article

The peroxisome proliferator BR931 kills FaO cells by p53-dependent apoptosis.

scientific article published on June 2004

The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas

scientific journal article

Thyroid Hormone Receptor β Agonist Induces β-Catenin-Dependent Hepatocyte Proliferation in Mice: Implications in Hepatic Regeneration

scientific article published on 24 May 2016

Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin-Driven Hepatocellular Cancer.

scientific article

Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats.

scientific article published on 23 April 2008

Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming

scientific article published on 15 January 2020

Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype.

scientific article

Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration

scientific article published on July 2014

Tri-iodothyronine induces hepatocyte proliferation by protein kinase A-dependent β-catenin activation in rodents.

scientific article published on 14 April 2014

Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration.

scientific article published on 14 April 2008

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury.

scientific article published on 4 December 2017

YAP activation is an early event and a potential therapeutic target in liver cancer development.

scientific article

Yes-associated protein promotes early hepatocyte cell cycle progression in regenerating liver after tissue loss

scientific article published on 27 November 2018

Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.

scientific article

miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling.

scientific article published in September 2018

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