List of works - Peter Faller

(Bio)chemical Strategies To Modulate Amyloid-β Self-Assembly

scientific article published on 17 July 2019

A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target ⬇️

scientific article published on November 23, 2012

A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides

scientific article

A terbium(iii) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(ii) in biological media

scientific article published on 30 March 2020

Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.

scientific article

Acrolein and Copper as Competitive Effectors of α-Synuclein

scientific article published on 28 January 2020

Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein

scientific article published on December 2003

Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.

scientific article

Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies

scientific article

Amyloid-beta peptide forms monomeric complexes with Cu(II) and Zn(II) prior to aggregation

scientific article published on 01 January 2007

Ascorbate Oxidation by Cu(Amyloid-β) Complexes: Determination of the Intrinsic Rate as a Function of Alterations in the Peptide Sequence Revealing Key Residues for Reactive Oxygen Species Production

scientific article published on 3 April 2018

Beta-carotene redox reactions in photosystem II: electron transfer pathway.

scientific article published in May 2001

Carotenoid oxidation in photosystem II.

scientific article

Characterization of the ZnII binding to the peptide amyloid-beta1-16 linked to Alzheimer's disease.

scientific article published in September 2005

Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteins

scientific article published in December 2017

Chlorophyll and carotenoid radicals in photosystem II studied by pulsed ENDOR.

scientific article published in January 2001

Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp

scientific article

Concept for simultaneous and specific in situ monitoring of amyloid oligomers and fibrils via Förster resonance energy transfer

scientific article

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones

scientific article published on 15 March 2022

Copper and heme-mediated Abeta toxicity: redox chemistry, Abeta oxidations and anti-ROS compounds.

scientific article published on January 2012

Copper coordination to native N-terminally modified versus full-length amyloid-β: second-sphere effects determine the species present at physiological pH

scientific article published on 14 November 2012

Copper in Alzheimer disease: too much, too little, or misplaced? ⬇️

scientific article published on November 11, 2011

Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity.

scientific article

Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

scientific article

Copper(I/II), α/β-Synuclein and Amyloid-β: Menage à Trois?

scientific article published on 4 September 2015

Copper(II) coordination to amyloid β: murine versus human peptide

scientific article published on 09 December 2010

Copper-Targeting Approaches in Alzheimer's Disease: How To Improve the Fallouts Obtained from in Vitro Studies

scientific article published on 17 June 2019

Cu(II) Binding to the N-Terminal Model Peptide of the Human Ctr2 Transporter at Lysosomal and Extracellular pH

scientific article published on 14 May 2019

Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His

scientific article published on 30 November 2017

Cu(II) affinity for the Alzheimer's peptide: tyrosine fluorescence studies revisited

scientific article published on 9 January 2013

Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.

scientific article published in January 2009

Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor.

scientific article published in October 1997

Dynamics of Zn(II) binding as a key feature in the formation of amyloid fibrils by Aβ11-28

scientific article published on 13 December 2011

Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal-thiolate clusters

scientific article published on 01 August 1999

Evidence that the principal CoII-binding site in human serum albumin is not at the N-terminus: implication on the albumin cobalt binding test for detecting myocardial ischemia

scientific article published on 03 February 2007

Folding of the prion peptide GGGTHSQW around the copper(II) ion: identifying the oxygen donor ligand at neutral pH and probing the proximity of the tryptophan residue to the copper ion.

scientific article published on 24 May 2008

Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Aβ Peptide and O2.

scientific article published on 2 December 2015

Growth inhibitory factor and zinc affect neural cell cultures in a tissue specific manner.

scientific article published in October 1998

How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study.

scientific article published on October 2016

How trimerization of CTR1 N-terminal model peptides tunes Cu-binding and redox-chemistry

scientific article published on 11 September 2020

Identification of key structural features of the elusive Cu-Aβ complex that generates ROS in Alzheimer's disease

scientific article published on 4 May 2017

Identifying, by first-principles simulations, Cu[amyloid-β] species making Fenton-type reactions in Alzheimer's disease

scientific article published on 13 December 2013

Impact of Cu(II) Binding on Structures and Dynamics of Aβ42 Monomer and Dimer: Molecular Dynamics Study.

scientific article published on 25 July 2016

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes.

scientific article published on 18 July 2009

Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties

scientific article published on 15 March 2012

Insights into the mechanisms of amyloid formation of Zn(II)-Ab11-28: pH-dependent zinc coordination and overall charge as key parameters for kinetics and the structure of Zn(II)-Ab11-28 aggregates

scientific article published on 05 July 2012

Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

scientific article published on 03 February 2012

Iron(II) binding to amyloid-β, the Alzheimer's peptide.

scientific article published on 29 July 2011

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

scientific article published on 6 June 2016

Isolation and characterization of a novel monomeric zinc- and heme-containing protein from bovine brain.

scientific article published in October 1996

Measurement of Interpeptidic Cu(II) Exchange Rate Constants by Static Fluorescence Quenching of Tryptophan

scientific article published on 12 April 2018

Mechanism of Cd2+ toxicity: Cd2+ inhibits photoactivation of Photosystem II by competitive binding to the essential Ca2+ site

scientific article published on 01 January 2005

Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28).

scientific article

Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principles

scientific article published on 29 May 2014

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

scientific article published on 4 May 2008

Metal-binding properties of the peptide APP170-188: a model of the ZnII-binding site of amyloid precursor protein (APP).

scientific article published in January 2005

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

scientific article published in October 2016

Metal-thiolate clusters in the C-terminal domain of human neuronal growth inhibitory factor (GIF)

scientific article published on 01 October 1998

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.

scientific article published on 04 April 2017

Metals and Alzheimer's disease.

scientific article published on 3 May 2011

Modeling copper binding to the amyloid-β peptide at different pH: toward a molecular mechanism for Cu reduction.

scientific article published on 26 September 2012

Modeling the Cu+ binding in the 1-16 region of the amyloid-β peptide involved in Alzheimer's disease.

scientific article published on November 2010

Molecular structure of the NQTrp inhibitor with the Alzheimer Aβ1-28 monomer

scientific article

N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications.

scientific article published on 16 January 2018

New insights into the coordination of Cu(II) by the amyloid-B 16 peptide from Fourier transform IR spectroscopy and isotopic labeling

scientific article published on 15 November 2011

Optical and TDPAC spectroscopy of Hg(II)-rubredoxin: model for a mononuclear tetrahedral [Hg(CysS)4]2- center. ISOLDE Collaboration

scientific article published on 01 June 2000

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

scientific article published on 18 October 2017

Photosystem II: evolutionary perspectives

scientific article

Platinoid complexes to target monomeric disordered peptides: a forthcoming solution against amyloid diseases?

scientific article published on 01 March 2014

Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

scientific article published on 05 February 2013

Pulse EPR spectroscopy reveals the coordination sphere of copper(II) ions in the 1-16 amyloid-beta peptide: a key role of the first two N-terminus residues

scientific article published on 01 January 2009

Rapid exchange of metal between Zn(7)-metallothionein-3 and amyloid-β peptide promotes amyloid-related structural changes

scientific article published on 10 February 2012

Rapid formation of the stable tyrosyl radical in photosystem II.

scientific article

Redox chemistry of copper-amyloid-beta: the generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state

scientific article published on 01 July 2007

Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions.

scientific article published on 27 March 2007

Reevaluation of Copper(I) Affinity for Amyloid‐β Peptides by Competition with Ferrozine—An Unusual Copper(I) Indicator ⬇️

scientific article published on December 21, 2011

Remote His50 Acts as a Coordination Switch in the High-Affinity N-Terminal Centered Copper(II) Site of α-Synuclein.

scientific article

Resolving intermediates in biological proton-coupled electron transfer: a tyrosyl radical prior to proton movement.

scientific article

Reversible turn-on fluorescent Cu(ii) sensors: rather dream than reality?

scientific article published on 30 August 2019

Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.

scientific article published on 22 April 2013

Similarities and differences of copper and zinc cations binding to biologically relevant peptides studied by vibrational spectroscopies

scientific article

Simultaneous femtosecond-pulse compression and second-harmonic generation in aperiodically poled KTiOPO(4)

scientific article published on 01 August 1999

Stress status of gudgeon (Gobio gobio) from rivers in Switzerland with and without input of sewage treatment plant effluent.

scientific article published in September 2003

Structural and thermodynamical properties of CuII amyloid-beta16/28 complexes associated with Alzheimer's disease.

scientific article published on 22 August 2006

Structural characterization of Cu(I) and Zn(II) sites in neuronal-growth-inhibitory factor by extended X-ray absorption fine structure (EXAFS).

scientific article published in July 1998

Switching on Endogenous Metal Binding Proteins in Parkinson's Disease

scientific article published on 19 February 2019

The Glutathione/Metallothionein System Challenges the Design of Efficient O2 -Activating Copper Complexes

scientific article published on 12 February 2020

The Na+/K+-ATPase and the amyloid-beta peptide aβ1-40 control the cellular distribution, abundance and activity of TRPC6 channels

scientific article published on 05 September 2015

The catalytically active copper-amyloid-Beta state: coordination site responsible for reactive oxygen species production

scientific article published on 3 September 2013

The heart of photosynthesis in glorious 3D

scientific article published on 01 June 2001

The role of metal ions in amyloid formation: general principles from model peptides.

scientific article published on March 2013

The stable tyrosyl radical in photosystem II: why D?

scientific article published on April 2004

Thermodynamic study of Cu2+ binding to the DAHK and GHK peptides by isothermal titration calorimetry (ITC) with the weaker competitor glycine

article published in 2011

Thioflavin derivatives as markers for amyloid-beta fibrils: insights into structural features important for high-affinity binding.

scientific article published in January 2008

Two functions, one molecule: a metal-binding and a targeting moiety to combat Alzheimer's disease.

scientific article published in May 2010

Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants

scientific article published on 01 July 2014

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease?

scientific article published on 6 June 2017

Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors

scientific article published on 6 November 2007

Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-β aggregates ⬇️

scientific article published on October 21, 2010

Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides.

scientific article published on 26 September 2016

Zinc(II) binds to the neuroprotective peptide humanin

scientific article published on 13 June 2006

Zinc(II) modulates specifically amyloid formation and structure in model peptides

scientific article published on 01 February 2011

Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity.

scientific article

pH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations.

scientific article published on 6 October 2011

List of works by Peter Faller

(Bio)chemical Strategies To Modulate Amyloid-β Self-Assembly

A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target ⬇️

A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides

A terbium(iii) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(ii) in biological media

Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.

Acrolein and Copper as Competitive Effectors of α-Synuclein

Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein

Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.

Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies

Amyloid-beta peptide forms monomeric complexes with Cu(II) and Zn(II) prior to aggregation

Ascorbate Oxidation by Cu(Amyloid-β) Complexes: Determination of the Intrinsic Rate as a Function of Alterations in the Peptide Sequence Revealing Key Residues for Reactive Oxygen Species Production

Beta-carotene redox reactions in photosystem II: electron transfer pathway.

Carotenoid oxidation in photosystem II.

Characterization of the ZnII binding to the peptide amyloid-beta1-16 linked to Alzheimer's disease.

Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteins

Chlorophyll and carotenoid radicals in photosystem II studied by pulsed ENDOR.

Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp

Concept for simultaneous and specific in situ monitoring of amyloid oligomers and fibrils via Förster resonance energy transfer

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones

Copper and heme-mediated Abeta toxicity: redox chemistry, Abeta oxidations and anti-ROS compounds.

Copper coordination to native N-terminally modified versus full-length amyloid-β: second-sphere effects determine the species present at physiological pH

Copper in Alzheimer disease: too much, too little, or misplaced? ⬇️

Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity.

Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

Copper(I/II), α/β-Synuclein and Amyloid-β: Menage à Trois?

Copper(II) coordination to amyloid β: murine versus human peptide

Copper-Targeting Approaches in Alzheimer's Disease: How To Improve the Fallouts Obtained from in Vitro Studies

Cu(II) Binding to the N-Terminal Model Peptide of the Human Ctr2 Transporter at Lysosomal and Extracellular pH

Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His

Cu(II) affinity for the Alzheimer's peptide: tyrosine fluorescence studies revisited

Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.

Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor.

Dynamics of Zn(II) binding as a key feature in the formation of amyloid fibrils by Aβ11-28

Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal-thiolate clusters

Evidence that the principal CoII-binding site in human serum albumin is not at the N-terminus: implication on the albumin cobalt binding test for detecting myocardial ischemia

Folding of the prion peptide GGGTHSQW around the copper(II) ion: identifying the oxygen donor ligand at neutral pH and probing the proximity of the tryptophan residue to the copper ion.

Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Aβ Peptide and O2.

Growth inhibitory factor and zinc affect neural cell cultures in a tissue specific manner.

How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study.

How trimerization of CTR1 N-terminal model peptides tunes Cu-binding and redox-chemistry

Identification of key structural features of the elusive Cu-Aβ complex that generates ROS in Alzheimer's disease

Identifying, by first-principles simulations, Cu[amyloid-β] species making Fenton-type reactions in Alzheimer's disease

Impact of Cu(II) Binding on Structures and Dynamics of Aβ42 Monomer and Dimer: Molecular Dynamics Study.

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes.

Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties

Insights into the mechanisms of amyloid formation of Zn(II)-Ab11-28: pH-dependent zinc coordination and overall charge as key parameters for kinetics and the structure of Zn(II)-Ab11-28 aggregates

Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

Iron(II) binding to amyloid-β, the Alzheimer's peptide.

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

Isolation and characterization of a novel monomeric zinc- and heme-containing protein from bovine brain.

Measurement of Interpeptidic Cu(II) Exchange Rate Constants by Static Fluorescence Quenching of Tryptophan

Mechanism of Cd2+ toxicity: Cd2+ inhibits photoactivation of Photosystem II by competitive binding to the essential Ca2+ site

Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28).

Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principles

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

Metal-binding properties of the peptide APP170-188: a model of the ZnII-binding site of amyloid precursor protein (APP).

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

Metal-thiolate clusters in the C-terminal domain of human neuronal growth inhibitory factor (GIF)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.

Metals and Alzheimer's disease.

Modeling copper binding to the amyloid-β peptide at different pH: toward a molecular mechanism for Cu reduction.

Modeling the Cu+ binding in the 1-16 region of the amyloid-β peptide involved in Alzheimer's disease.

Molecular structure of the NQTrp inhibitor with the Alzheimer Aβ1-28 monomer

N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications.

New insights into the coordination of Cu(II) by the amyloid-B 16 peptide from Fourier transform IR spectroscopy and isotopic labeling

Optical and TDPAC spectroscopy of Hg(II)-rubredoxin: model for a mononuclear tetrahedral [Hg(CysS)4]2- center. ISOLDE Collaboration

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

Photosystem II: evolutionary perspectives

Platinoid complexes to target monomeric disordered peptides: a forthcoming solution against amyloid diseases?

Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

Pulse EPR spectroscopy reveals the coordination sphere of copper(II) ions in the 1-16 amyloid-beta peptide: a key role of the first two N-terminus residues

Rapid exchange of metal between Zn(7)-metallothionein-3 and amyloid-β peptide promotes amyloid-related structural changes

Rapid formation of the stable tyrosyl radical in photosystem II.

Redox chemistry of copper-amyloid-beta: the generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state

Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions.

Reevaluation of Copper(I) Affinity for Amyloid‐β Peptides by Competition with Ferrozine—An Unusual Copper(I) Indicator ⬇️

Remote His50 Acts as a Coordination Switch in the High-Affinity N-Terminal Centered Copper(II) Site of α-Synuclein.

Resolving intermediates in biological proton-coupled electron transfer: a tyrosyl radical prior to proton movement.

Reversible turn-on fluorescent Cu(ii) sensors: rather dream than reality?