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List of works by Francis C Lynn

A mouse model for monitoring islet cell genesis and developing therapies for diabetes

scientific article

All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes

scientific article

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

scientific article published on 09 October 2020

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells.

scientific article

Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization

scientific article published on 01 August 1999

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

scientific article

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

scientific article published on March 2003

Friend and foe: β-cell Ca2+ signaling and the development of diabetes

scientific article published on 24 December 2018

Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).

scientific article published on 11 January 2016

Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.

scientific article published in January 2003

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

scientific article published on 21 January 2003

Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin.

scientific article

Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

scientific article published on 8 May 2014

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network

scientific journal article

Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide

scientific article published on 01 March 1999

In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants

scientific article published on 18 March 2019

Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology

scientific article

Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes

scientific article

Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells

scientific article published in January 2018

Noncoding RNAs

scientific article published on 29 December 2012

Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

scientific article

Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells ⬇️

scientific article

Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells.

scientific article published on 08 May 2013

Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.

scientific article published in April 2017

Quetiapine treatment in youth is associated with decreased insulin secretion

scientific article published in June 2014

Reawakening the Duct Cell Progenitor?

scientific article published in January 2016

Recessive mutations in ATP8A2 cause severe hypotonia, cognitive impairment, hyperkinetic movement disorders and progressive optic atrophy

scientific article published on 31 May 2018

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

scientific article

Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization

scientific article

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat

scientific article published on 29 August 2007

Rfx6 directs islet formation and insulin production in mice and humans

scientific article

SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a.

scientific article

SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models.

scientific article published on 5 February 2015

Sequence and epigenetic determinants in the regulation of the Math6 gene by Neurogenin3.

scientific article published on 14 June 2011

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors

scientific article published on 01 December 2018

Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP).

scientific article published in March 2003

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

scientific article published on 24 January 2020

TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm

scientific article

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.

scientific article

The p300 and CBP Transcriptional Coactivators are Required for Beta Cell and Alpha Cell Proliferation

scientific article published on 7 December 2017

The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development

scientific journal article

Use-dependent activation of neuronal Kv1.2 channel complexes.

scientific article

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