List of works - Derek G Doherty

(E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated Vgamma9Vdelta2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells.

scientific article published on 20 March 2010

A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens.

scientific article published on 8 April 2006

Activation and Regulation of B Cell Responses by Invariant Natural Killer T Cells.

scientific article

Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide.

scientific article published on 13 April 2011

Activation-Induced Expression of CD56 by T Cells Is Associated With a Reprogramming of Cytolytic Activity and Cytokine Secretion Profile In Vitro

scientific article published on 20 September 2006

Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis

article

Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury

scientific article published on 28 September 2017

Altered Toll-Like Receptor Signalling in Children with Down Syndrome

scientific article published on 12 September 2019

Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity.

scientific article published on 15 May 2015

Altered endotoxin responsiveness in healthy children with Down syndrome

scientific article published on 03 November 2018

Amino acid substitutions at position 38 of the DRβ polypeptide confer susceptibility to and protection from primary sclerosing cholangitis

article

Antigen-specific immune tolerance in the liver

scientific article published on 01 October 2019

Autoimmune hepatitis in childhood: a 20-year experience.

scientific article

CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver.

scientific article

CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies

scientific article published on 20 February 2020

CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection.

scientific article

Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by Vδ1 T cells.

scientific article published on 11 May 2015

Characterising cytokine gene expression signatures in patients with severe sepsis

scientific article published on 02 July 2013

Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia.

scientific article published in January 2005

Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses

article

Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-γ or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection.

scientific article published on 3 September 2014

Consensus statement from the BJA Workshop on Cancer and Anaesthesia

scientific article published on 7 August 2014

Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells.

scientific article published on 05 June 2013

Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection

scientific article published in July 2002

Defining the outcome of immunosuppression withdrawal after liver transplantation

article

Dendritic cells: regulators of hepatic immunity or tolerance?

scientific article published on 01 January 2001

Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells.

scientific article published on October 2002

Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells

scientific article

Distinct subpopulations of ?? T cells are present in normal and tumor-bearing human liver

scientific article published on 01 October 2004

Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer

article

Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis

scientific article published on 28 October 2019

Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells

scientific article published on 12 February 2018

Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver.

scientific article published in May 2003

Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma

scientific article published on 12 January 2018

Genetic bases of autoimmune hepatitis.

scientific article

Genotype analysis for delta F508, G551D and R553X mutations in children and young adults with cystic fibrosis with and without chronic liver disease.

scientific article

Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.

scientific article

HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes.

scientific article published on January 2014

HLA DQA, DQB, and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British caucasoids

scientific article (publication date: May 1992)

HLA genotyping of colorectal carcinoma in the Chinese population

scientific article published on May 1, 1992

HLA phenotypes and gene polymorphisms in juvenile liver disease associated with α1-antitrypsin deficiency

article

HLA-DRB GENES AND ANTIRIBOSOMAL P ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

article

Hepatic expression of IL-15 mRNA is associated with liver graft acceptance.

scientific article

Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development

scientific article published in October 2004

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion

scientific article published on 2 May 2011

Hepatitis C virus--T-cell responses and viral escape mutations.

scientific article

High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection

scientific article

Hospital-acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression

scientific article published on 9 September 2010

Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype.

scientific article published on 24 June 2016

Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system.

scientific article published on 28 January 2015

Human Vδ2(+) γδ T Cells Differentially Induce Maturation, Cytokine Production, and Alloreactive T Cell Stimulation by Dendritic Cells and B Cells.

scientific article published on 19 December 2014

Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells.

scientific article published on 10 February 2018

Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules

scientific article published on 01 November 2002

Human invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro

scientific article published on 12 July 2013

Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation.

scientific article

IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer.

scientific article published on 19 June 2013

Immunity, tolerance and autoimmunity in the liver: A comprehensive review.

scientific article published on 07 September 2015

Increased Frequencies of Circulating IFN-γ-Producing Vδ1(+) and Vδ2(+) γδ T Cells in Patients with Asymptomatic Persistent Hepatitis B Virus Infection.

scientific article published on 19 March 2015

Increased systemic inflammation in children with Down syndrome

scientific article published on 27 November 2019

Influence of human leukocyte antigen matching on liver allograft survival and rejection: "the dualistic effect"

scientific article published on 01 June 1993

Innate Lymphocyte Th1 and Th17 Responses in Elderly Hospitalised Patients with Infection and Sepsis

scientific article published on 17 June 2020

Interleukin-15 is associated with disease severity in viral bronchiolitis

scientific article published on 5 November 2015

Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity.

scientific article

Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterisation

scientific article published on 01 August 2000

Major histocompatibility complex associations with primary antiphospholipid syndrome

scientific article published on 01 January 1992

Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern chinese

article

Mucosal-associated invariant T cells are depleted and functionally altered in patients with common variable immunodeficiency.

scientific article published on 20 December 2016

Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Vα24-JαQ and γδ T cell receptor bearing cells

article

Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells.

scientific article published on 6 April 2018

Persistent changes in circulating and intestinal γδ T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease.

scientific article

Polymorphism in the Human Complement C4 Genes and Genetic Susceptibility to Autoimmune Hepatitis

article

Post-operative infection and sepsis in humans is associated with deficient gene expression of γc cytokines and their apoptosis mediators

scientific article published on 28 June 2011

Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells.

scientific article

Resident human hepatitis lymphocytes are phenotypically different from circulating lymphocytes

article

Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8+ invariant natural killer T cells

scientific article published on 2 August 2017

Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-15

scientific article published on 01 September 2001

Selective effects of radiotherapy on viability and function of invariant natural killer T cells in vitro

scientific article published on 18 January 2020

Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy.

scientific article published on 10 December 2002

Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer.

scientific article published in May 2003

Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.

scientific article published on October 1998

Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype

scientific article published on December 1, 1992

The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns

scientific article published on 01 August 1999

The major histocompatibility complex influences the development of chronic liver disease in male children and young adults with cystic fibrosis

article

The molecular genetics of autoimmune liver disease.

scientific article published on July 1994

The role of the liver in the migration of parasites of global significance

scientific article published on 08 November 2019

Unmet needs persist in pediatric HIV programs: lessons from selected case studies in Uganda

scientific article published on May 2017

Viral Bronchiolitis is Associated With Altered Cytokine Gene Expression and Lymphocyte Activation Status

scientific article published on 18 July 2016

List of works by Derek G Doherty

(E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated Vgamma9Vdelta2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells.

A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens.

Activation and Regulation of B Cell Responses by Invariant Natural Killer T Cells.

Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide.

Activation-Induced Expression of CD56 by T Cells Is Associated With a Reprogramming of Cytolytic Activity and Cytokine Secretion Profile In Vitro

Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis

Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury

Altered Toll-Like Receptor Signalling in Children with Down Syndrome

Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity.

Altered endotoxin responsiveness in healthy children with Down syndrome

Amino acid substitutions at position 38 of the DRβ polypeptide confer susceptibility to and protection from primary sclerosing cholangitis

Antigen-specific immune tolerance in the liver

Autoimmune hepatitis in childhood: a 20-year experience.

CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver.

CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies

CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection.

Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by Vδ1 T cells.

Characterising cytokine gene expression signatures in patients with severe sepsis

Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia.

Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses

Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-γ or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection.

Consensus statement from the BJA Workshop on Cancer and Anaesthesia

Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells.

Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection

Defining the outcome of immunosuppression withdrawal after liver transplantation

Dendritic cells: regulators of hepatic immunity or tolerance?

Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells.

Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells

Distinct subpopulations of ?? T cells are present in normal and tumor-bearing human liver

Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer

Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis

Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells

Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver.

Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma

Genetic bases of autoimmune hepatitis.

Genotype analysis for delta F508, G551D and R553X mutations in children and young adults with cystic fibrosis with and without chronic liver disease.

Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.

HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes.

HLA DQA, DQB, and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British caucasoids

HLA genotyping of colorectal carcinoma in the Chinese population

HLA phenotypes and gene polymorphisms in juvenile liver disease associated with α1-antitrypsin deficiency

HLA-DRB GENES AND ANTIRIBOSOMAL P ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

Hepatic expression of IL-15 mRNA is associated with liver graft acceptance.

Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion

Hepatitis C virus--T-cell responses and viral escape mutations.

High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection

Hospital-acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression

Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype.

Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system.

Human Vδ2(+) γδ T Cells Differentially Induce Maturation, Cytokine Production, and Alloreactive T Cell Stimulation by Dendritic Cells and B Cells.

Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells.

Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules

Human invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro

Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation.

IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer.

Immunity, tolerance and autoimmunity in the liver: A comprehensive review.

Increased Frequencies of Circulating IFN-γ-Producing Vδ1(+) and Vδ2(+) γδ T Cells in Patients with Asymptomatic Persistent Hepatitis B Virus Infection.

Increased systemic inflammation in children with Down syndrome

Influence of human leukocyte antigen matching on liver allograft survival and rejection: "the dualistic effect"

Innate Lymphocyte Th1 and Th17 Responses in Elderly Hospitalised Patients with Infection and Sepsis

Interleukin-15 is associated with disease severity in viral bronchiolitis

Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity.

Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterisation

Major histocompatibility complex associations with primary antiphospholipid syndrome

Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern chinese

Mucosal-associated invariant T cells are depleted and functionally altered in patients with common variable immunodeficiency.

Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Vα24-JαQ and γδ T cell receptor bearing cells

Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells.

Persistent changes in circulating and intestinal γδ T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease.

Polymorphism in the Human Complement C4 Genes and Genetic Susceptibility to Autoimmune Hepatitis

Post-operative infection and sepsis in humans is associated with deficient gene expression of γc cytokines and their apoptosis mediators

Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells.

Resident human hepatitis lymphocytes are phenotypically different from circulating lymphocytes

Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8+ invariant natural killer T cells

Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-15

Selective effects of radiotherapy on viability and function of invariant natural killer T cells in vitro

Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy.

Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer.