List of works - Samuel Silvestre

3,3′-Diamino-N-methyldipropylamine as a versatile affinity ligand

scientific article published on 03 February 2015

5-Hydrazinylethylidenepyrimidines effective against multidrug-resistant Acinetobacter baumannii: Synthesis and in vitro biological evaluation of antibacterial, radical scavenging and cytotoxic activities

scientific article published on 21 June 2019

Bismuth compounds in medicinal chemistry.

scientific article published on July 2012

Bismuth(III) reagents in steroid and terpene chemistry.

scientific article published on 04 April 2011

Cell proliferation effects of calix[4]arene derivatives

Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test.

scientific article published in January 2018

Dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone in male reproductive health: Implications of differential regulation of human Sertoli cells metabolic profile

scientific article published on 29 June 2015

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology.

scientific article published on 28 December 2016

Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates

scientific article published on 14 March 2017

Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

scientific article published on 20 November 2015

Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study

From Xanthine Oxidase Inhibition to In Vivo Hypouricemic Effect: An Integrated Overview of In Vitro and In Vivo Studies with Focus on Natural Molecules and Analogues

scientific article published on 25 February 2020

Gastrodia elata and epilepsy: Rationale and therapeutic potential

scientific article

HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance

scientific article published on 27 August 2014

Natural Products as a Source for New Leads in Gout Treatment

scientific article published on 15 May 2020

New applications for bismuth(III) salts in organic synthesis: from bulk chemicals to steroid and terpene chemistry

scientific article published on 01 January 2012

Novel 4-acetamide-2-alkylthio-N-acetanilides resembling nimesulide: Synthesis, cell viability evaluation and in silico studies

scientific article

Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones.

scientific article published on 5 April 2017

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

scientific article published on 14 July 2017

Potential antitumoral 3,4-dihydropyrimidin-2-(1H)-ones: synthesis, in vitro biological evaluation and QSAR studies

scholarly article in RSC Advances, vol. 6 no. 88, 2016

Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches

scientific article published in 2021

Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders

scientific article published on 11 November 2016

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays

scientific article published on 22 August 2017

Simultaneous Quantification of Antidepressants and Metabolites in Urine and Plasma Samples by GC–MS for Therapeutic Drug Monitoring

Sodium Tripolyphosphate: an excipient with intrinsic in vitro anti-Candida activity

scientific article published on 29 September 2011

Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases.

scientific article published on 18 May 2013

Steroidal oximes: useful compounds with antitumor activities

scientific article published on 3 October 2017

Synthesis and process optimization of symmetric and unsymmetric barbiturates C5-coupled with 2,1-benzisoxazoles

scientific article published on 14 March 2019

Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-dihydropyrimidin-2-(1H)-thiones

Targeting of mitochondria-endoplasmic reticulum by fluorescent macrocyclic compounds.

scientific article

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.

scientific article published on 27 November 2017

List of works by Samuel Silvestre

3,3′-Diamino-N-methyldipropylamine as a versatile affinity ligand

5-Hydrazinylethylidenepyrimidines effective against multidrug-resistant Acinetobacter baumannii: Synthesis and in vitro biological evaluation of antibacterial, radical scavenging and cytotoxic activities

Bismuth compounds in medicinal chemistry.

Bismuth(III) reagents in steroid and terpene chemistry.

Cell proliferation effects of calix[4]arene derivatives

Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test.

Dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone in male reproductive health: Implications of differential regulation of human Sertoli cells metabolic profile

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology.

Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates

Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study

From Xanthine Oxidase Inhibition to In Vivo Hypouricemic Effect: An Integrated Overview of In Vitro and In Vivo Studies with Focus on Natural Molecules and Analogues

Gastrodia elata and epilepsy: Rationale and therapeutic potential

HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance

Natural Products as a Source for New Leads in Gout Treatment

New applications for bismuth(III) salts in organic synthesis: from bulk chemicals to steroid and terpene chemistry

Novel 4-acetamide-2-alkylthio-N-acetanilides resembling nimesulide: Synthesis, cell viability evaluation and in silico studies

Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones.

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

Potential antitumoral 3,4-dihydropyrimidin-2-(1H)-ones: synthesis, in vitro biological evaluation and QSAR studies

Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches

Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays

Simultaneous Quantification of Antidepressants and Metabolites in Urine and Plasma Samples by GC–MS for Therapeutic Drug Monitoring

Sodium Tripolyphosphate: an excipient with intrinsic in vitro anti-Candida activity

Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases.

Steroidal oximes: useful compounds with antitumor activities

Synthesis and process optimization of symmetric and unsymmetric barbiturates C5-coupled with 2,1-benzisoxazoles

Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-dihydropyrimidin-2-(1H)-thiones

Targeting of mitochondria-endoplasmic reticulum by fluorescent macrocyclic compounds.

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.