List of works - Thorsten Buch

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

scientific article

Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-κB signaling.

scientific article published on June 2017

Agouti-related peptide-expressing neurons are mandatory for feeding

scientific article

Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis

scientific article published on 01 November 2005

B-cell-intrinsic STAT6 signaling controls germinal center formation

scientific article published on 21 May 2014

Benefits of a factorial design focusing on inclusion of female and male animals in one experiment

scientific article published on 13 April 2019

Bone marrow chimeras-a vital tool in basic and translational research

scientific article published on 26 April 2019

Building a zoo of mice for genetic analyses: a comprehensive protocol for the rapid generation of BAC transgenic mice

scientific article published in April 2010

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

scientific article

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

scientific article published on 6 November 2014

Correction: Inducible Ablation of Melanopsin-Expressing Retinal Ganglion Cells Reveals Their Central Role in Non-Image Forming Visual Responses

Correction: Inducible Ablation of Melanopsin-Expressing Retinal Ganglion Cells Reveals Their Central Role in Non-Image Forming Visual Responses.

scientific article

Critical functions for c-Myb at three checkpoints during thymocyte development

scientific article

Cytokine reporter mice in immunological research: perspectives and lessons learned ⬇️

scientific article published on November 11, 2010

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

scientific article published on 8 March 2009

DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma

scientific article published on 30 November 2012

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

scientific article

Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing

scientific article published on 27 February 2010

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs

scientific article published on October 2008

Efficient B cell depletion via diphtheria toxin in CD19-Cre/iDTR mice

scientific article published on 27 March 2013

Erratum: PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

scientific article published on 29 November 2017

Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos

scientific article

Expression analysis data of BCL11A and γ-globin genes in KU812 and KG-1 cell lines after CRISPR/Cas9-mediated BCL11A enhancer deletion

scientific article published on 11 December 2019

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

article

Fecal microbiota transfer (FMT) in a patient with refractory irritable bowel syndrome

scientific article published on 11 August 2015

Follicular dendritic cells emerge from ubiquitous perivascular precursors

scientific article published on July 2012

Gamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific manner

scientific article published on 14 March 2007

Generation of bacterial artificial chromosome (BAC) transgenic mice

scientific article published in January 2014

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis

scientific article published on 13 March 2018

Host microbiota constantly control maturation and function of microglia in the CNS.

scientific article

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

scientific article published on 10 December 2012

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis

scientific article published on 01 December 2007

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1

scientific article published on 06 May 2014

Identification of novel immune phenotypes for allergic and nonallergic childhood asthma

scientific article published on 13 September 2014

Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses

scientific article

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

scientific article

Insulin-like growth factor-1 controls type 2 T cell-independent B cell response

scientific article

Is BAC transgenesis obsolete? State of the art in the era of designer nucleases

scientific article published on 30 July 2012

MHC class II expression through a hitherto unknown pathway supports T helper cell-dependent immune responses: implications for MHC class II deficiency

scientific journal article

MHC-restricted T cell receptor signaling is required for αβ TCR replacement of the pre T cell receptor

scientific article published on 01 February 2008

Manipulation of T cell function and conditional gene targeting in T cells

scientific article published in January 2014

Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation

scientific article published on 18 July 2014

Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage.

scientific article

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes

scientific article

Metabolism gene signatures and surgical site infections in abdominal surgery

scientific article published on 16 January 2015

NONO couples the circadian clock to the cell cycle

scientific article

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.

scientific article published on 26 August 2013

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

scientific article published on 15 November 2017

Primary oligodendrocyte death does not elicit anti-CNS immunity

scientific article published on 26 February 2012

Protection from autoimmune brain inflammation in mice lacking IFN-regulatory factor-1 is associated with Th2-type cytokines

scientific article published in July 2003

Protection from autoimmunity by DNA vaccination against T-cell receptor.

scientific article published on January 2006

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40

scientific article

Selection of higher order regression models in the analysis of multi-factorial transcription data

scientific article

Selective erasure of a fear memory

scientific article

T cell-specific inactivation of mouse CD2 by CRISPR/Cas9.

scientific article published on 23 February 2016

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function

scientific article

Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease

scientific article published on 27 April 2019

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

scientific article published on 25 November 2015

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

scientific article

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

scientific article published on 01 March 2019

The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth

scientific article published on 18 September 2013

The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration

scientific article published on 19 April 2012

The more the merrier? Scoring, statistics and animal welfare in experimental autoimmune encephalomyelitis

scientific article published on December 2016

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

scientific article published on 27 July 2015

Tissue adaptation of regulatory and intraepithelial CD4⁺ T cells controls gut inflammation

scientific article

Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion

scientific article published on October 2008

Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint

scientific article published in April 2012

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection

scientific article

List of works by Thorsten Buch

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-κB signaling.

Agouti-related peptide-expressing neurons are mandatory for feeding

Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis

B-cell-intrinsic STAT6 signaling controls germinal center formation

Benefits of a factorial design focusing on inclusion of female and male animals in one experiment

Bone marrow chimeras-a vital tool in basic and translational research

Building a zoo of mice for genetic analyses: a comprehensive protocol for the rapid generation of BAC transgenic mice

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

Correction: Inducible Ablation of Melanopsin-Expressing Retinal Ganglion Cells Reveals Their Central Role in Non-Image Forming Visual Responses

Correction: Inducible Ablation of Melanopsin-Expressing Retinal Ganglion Cells Reveals Their Central Role in Non-Image Forming Visual Responses.

Critical functions for c-Myb at three checkpoints during thymocyte development

Cytokine reporter mice in immunological research: perspectives and lessons learned ⬇️

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs

Efficient B cell depletion via diphtheria toxin in CD19-Cre/iDTR mice

Erratum: PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos

Expression analysis data of BCL11A and γ-globin genes in KU812 and KG-1 cell lines after CRISPR/Cas9-mediated BCL11A enhancer deletion

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

Fecal microbiota transfer (FMT) in a patient with refractory irritable bowel syndrome

Follicular dendritic cells emerge from ubiquitous perivascular precursors

Gamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific manner

Generation of bacterial artificial chromosome (BAC) transgenic mice

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis

Host microbiota constantly control maturation and function of microglia in the CNS.

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1

Identification of novel immune phenotypes for allergic and nonallergic childhood asthma

Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

Insulin-like growth factor-1 controls type 2 T cell-independent B cell response

Is BAC transgenesis obsolete? State of the art in the era of designer nucleases

MHC class II expression through a hitherto unknown pathway supports T helper cell-dependent immune responses: implications for MHC class II deficiency

MHC-restricted T cell receptor signaling is required for αβ TCR replacement of the pre T cell receptor

Manipulation of T cell function and conditional gene targeting in T cells

Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation

Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage.

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes

Metabolism gene signatures and surgical site infections in abdominal surgery

NONO couples the circadian clock to the cell cycle

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

Primary oligodendrocyte death does not elicit anti-CNS immunity

Protection from autoimmune brain inflammation in mice lacking IFN-regulatory factor-1 is associated with Th2-type cytokines

Protection from autoimmunity by DNA vaccination against T-cell receptor.

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40

Selection of higher order regression models in the analysis of multi-factorial transcription data

Selective erasure of a fear memory

T cell-specific inactivation of mouse CD2 by CRISPR/Cas9.

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function

Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth

The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration

The more the merrier? Scoring, statistics and animal welfare in experimental autoimmune encephalomyelitis

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

Tissue adaptation of regulatory and intraepithelial CD4⁺ T cells controls gut inflammation

Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion

Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection