Search filters

Authors whose works are in public domain in at least one jurisdiction

List of works by Jan G Hengstler

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

scientific article published on 29 April 2016

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

scientific article published on 12 January 2015

A Comprehensive Analysis of Human Gene Expression Profiles Identifies Stromal Immunoglobulin C as a Compatible Prognostic Marker in Human Solid Tumors

article

A comprehensive review about micronuclei: mechanisms of formation and practical aspects in genotoxicity testing

scientific article published on 01 August 2011

A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein

scientific article published on 19 August 2017

A microfluidic array with cellular valving for single cell co-culture

scientific article published on 27 October 2010

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

scientific journal article

A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms

scientific article published on 01 April 1996

A new series of review articles on drug metabolizing enzymes: nomenclature of isoenzyme families, genetic organization, polymorphisms, substrate specificities, clinical relevance and role in carcinogenesis.

scientific article published in July 2008

A rapid and easy to handle thermoluminescence based technique for evaluation of carbon tetrachloride-induced oxidative stress on rat hepatocytes.

scientific article published on 12 February 2009

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

scientific article

A special issue on metal toxicity

scientific article published on 01 August 2008

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation

scientific article

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

scientific article

Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer

article published in 2014

Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons

scientific article published on 12 April 2014

Activated ErbB3 Translocates to the Nucleus via Clathrin-independent Endocytosis, Which Is Associated with Proliferating Cells

scientific article published on 30 December 2015

Activity of O6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students

scientific article published on 01 February 1999

Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue

scientific article

Adverse outcome pathways: a concise introduction for toxicologists

scientific article published on 28 June 2017

Adverse outcome pathways: opportunities, limitations and open questions

scientific article published on 19 October 2017

Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice

scientific journal article

Agitation effects on submerged growth and product formation of Aspergillus niger.

scientific article

Alcohol-induced liver injury: how a small molecule overwhelms one of the cell types with the best regeneration capacity of the human body.

scientific article

Allowing pseudoscience into EU risk assessment processes is eroding public trust in science experts and in science as a whole: The bigger picture

scientific article published on 21 July 2016

Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity

scientific article published on 19 April 2016

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH).

scientific article published on 06 March 2008

Aluminium and lead toxicity revisited: mechanisms explaining the particular sensitivity of the brain to oxidative damage.

scientific article published in November 2008

An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".

scientific article published on January 2011

Analysis of DNA single-strand breaks in human venous blood: a technique which does not require isolation of white blood cells

scientific article published on 01 January 1997

Angiogenesis and fibroblast proliferation precede formation of recurrent tumors after radiation therapy in nude mice

scientific article published on 01 March 2002

Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis.

scientific article

Assessment criteria for compensation of occupational bladder cancer

scientific article published on January 2013

Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate

scientific article published in November 1999

Augmenter of liver regeneration (ALR) protects human hepatocytes against apoptosis.

scientific article published on 23 November 2010

BDNF Val66Met polymorphism and goal-directed behavior in healthy elderly - evidence from auditory distraction.

scientific article published on 4 September 2012

Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles.

scientific article published on 24 August 2005

Bile acids as colon carcinogens and coffee ingredients as antagonists

scientific article published on 01 August 2011

Bile canalicular dynamics in hepatocyte sandwich cultures

scientific article published on 18 August 2015

Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation.

scientific article published on 2 October 2012

Bladder cancer documentation of causes: multilingual questionnaire, 'bladder cancer doc'.

scientific article published on June 2012

Bladder cancer in crack testers applying azo dye-based sprays to metal bodies

scientific article published in January 2012

Bladder cancer survival in a former industrial area in Saxony-Anhalt, Germany

scientific article published on 01 January 2012

Buckyballs (fullerenes): free radical sponges or inflammatory agents?

scientific article published on 01 December 2012

C-myc mRNA expression in epithelial ovarian carcinomas in relation to estrogen receptor status, metastatic spread, survival time, FIGO stage, and histologic grade and type

scientific article published on 01 January 1998

CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)

scientific article

Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.

scientific article

Calibrating a Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness

scientific article published in 2022

Can drinking tea prevent cancer? A controversy revisited

scientific article

Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk

scientific article published on 01 December 2000

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

scientific article published on 3 February 2018

Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate.

scientific article

Characterization of a Fetal Liver Cell Population Endowed with Long-Term Multiorgan Endothelial Reconstitution Potential

scientific article published on 12 September 2016

Cholestasis-induced adaptive remodeling of interlobular bile ducts

scientific article published on 26 November 2015

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis

scientific article

Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities

scientific article published on 31 October 2012

Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis

scientific article published on January 2014

Clarifying haplotype ambiguity of NAT2 in multi-national cohorts.

scientific article

Cluster-localized sparse logistic regression for SNP data.

scientific article

Combination therapy with low-dose transpupillary thermotherapy and intravitreal ranibizumab for neovascular age-related macular degeneration: a 24-month prospective randomised clinical study

scientific article published on 12 January 2012

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

scientific article

Comparative analysis of 3D culture methods on human HepG2 cells

scientific article published on 12 February 2016

Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse.

scientific article published on 16 December 2003

Comparing the growth kinetics of cell populations in two and three dimensions

scientific article published on 12 May 2009

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.

scientific article published on 30 December 2016

Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes.

scientific article

Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration.

scientific article

Conflict of interest statements: current dilemma and a possible way forward.

scientific article published on 28 June 2016

Contrast agent-induced nephrotoxicity: role of oxidative stress and apoptosis through the mitochondrial pathway

scientific article published on 01 March 2011

Contribution of c-erbB-2 and topoisomerase IIalpha to chemoresistance in ovarian cancer.

scientific article

Control of oxidative stress by the Keap1-Nrf2 pathway

scientific article published on 01 April 2011

Control of the mutagenicity of aromatic amines by protein kinases and phosphatases. I. The protein phosphatase inhibitors okadaic acid and ortho-vanadate drastically reduce the mutagenicity of aromatic amines

scientific article published on 01 January 1997

Control of the mutagenicity of arylamines by protein kinases and phosphatases: II. Lack of response of rat liver N-acetyl transferases to phosphorylation modulators

scientific article published on 01 January 1997

Coordinates in the universe of node-negative breast cancer revisited.

scientific article published on 24 March 2009

Correction: Distinct SNP Combinations Confer Susceptibility to Urinary Bladder Cancer in Smokers and Non-Smokers

scientific article published on 3 September 2015

Could treatment with neohepatocytes benefit patients with decompensated chronic liver disease?

scientific article published on 01 November 2007

Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine.

scientific article published in January 2017

Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A.

scientific article

Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction

scientific article published on 01 February 2000

DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids.

scientific article published in March 1995

DNA damage in nurses handling antineoplastic agents

scientific article published on 01 March 1995

DNA single strand break analysis in mononuclear blood cells of petrol pump attendants

scientific article published on 01 January 1995

DNA strand break induction, mutagenicity, and cytotoxicity of the mycotoxins 11-β-hydroxy-7-deoxy-rosenonolactone, rosenonolactone, and trichothecin

scientific article published in September 1992

DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin

scientific article published on 01 October 1992

Decrease of global methylation improves significantly hepatic differentiation of Ad-MSCs: possible future application for urea detoxification

scientific article published on 10 April 2012

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests

scientific article

Dephosphorylation of p-ERK1/2 in relation to tumor remission after HER-2 and Raf1 blocking therapy in a conditional mouse tumor model.

scientific article published on May 2006

Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells.

scientific article published on 21 January 2014

Detection of primary DNA damage: applicability to biomonitoring of genotoxic occupational exposure and in clinical therapy.

scientific article published on January 1995

Development of a strategy for biological monitoring in a chemical plant producing 3,3'-dichlorobenzidine dihydrochloride.

scientific article published in January 2012

Developments in industrial and occupational toxicology: REACH, toxicogenomics, mycotoxins, lead, asbestos, boron, bitumen, deletions polymorphisms and SNP interactions: meeting report of the 16th EUROTOX training and discussion session

scientific article published on 21 May 2008

Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes

scientific article published on 01 January 2010

Diabetes mellitus is a multivariate independent prognostic factor in endometrial carcinoma: a clinicopathologic study on 313 patients

scientific article published on 01 January 2007

Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement.

scientific article

Differentiation and selection of hepatocyte precursors in suspension spheroid culture of transgenic murine embryonic stem cells

scientific article

Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers

scientific article

Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes

scientific article

Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P450 1A1.

scientific article published on 18 July 2008

Distribution of detoxifying genes polymorphism in Maharastrian population of central India

scientific article published on 14 September 2007

Downregulation of beta2-microglobulin in human cord blood somatic stem cells after transplantation into livers of SCID-mice: an escape mechanism of stem cells?

scientific article published on 01 June 2002

Drug metabolizing capacity of cryopreserved human, rat, and mouse liver parenchymal cells in suspension

scientific article published on 01 December 1999

EDI3 links choline metabolism to integrin expression, cell adhesion and spreading

scientific article

ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction.

scientific article published on 6 April 2010

ERBB2 induces an antiapoptotic expression pattern of Bcl-2 family members in node-negative breast cancer.

scientific article published on 12 January 2010

ERBB2 overexpression triggers transient high mechanoactivity of breast tumor cells.

scientific article

ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions.

scientific article published on April 2006

EU research activities in alternative testing strategies: current status and future perspectives

scientific article published on 01 December 2009

Editorial

scientific article published in December 2013

Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer

scientific article published on 30 March 2010

Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis

scientific article

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy

scientific article

ErbB-3 predicts survival in ovarian cancer

scientific article published on 8 August 2006

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

scientific article published on 01 January 2020

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

scientific article

Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by 31P NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines

scientific article

Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases.

scientific article published in January 2005

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

scientific article

Expression of c-erbB-2 and topoisomerase II alpha in relation to chemoresistance in ovarian cancer

scientific article

Expression patterns and novel splicing variants of glutathione-S-transferase isoenzymes of human lung and hepatocyte cell lines

scientific article published on 24 February 2006

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis

scientific article published in June 2009

Failure in drug development: the role of inhibition and induction of cytochrome P450 enzymes

scientific article published on 01 October 2008

Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers.

scientific article published in September 2007

Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma

scientific article published on 4 April 2014

Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells

scientific article published on 12 November 2014

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

scientific article published on 25 March 2016

Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells

scientific article published on 27 March 2014

From bisphenol A to bisphenol F and a ban of mustard due to chronic low-dose exposures?

scientific article published on 02 February 2016

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.

scientific article

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 22 September 2017

Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers.

scientific article

Gelsolin Is Associated with Longer Metastasis-free Survival and Reduced Cell Migration in Estrogen Receptor-positive Breast Cancer.

scientific article published on October 2015

Gene array screening for identification of drugs with low levels of adverse side effects

article

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

scientific article published on 23 June 2016

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

scientific article published on 25 May 2015

Generation of human hepatocytes by stem cell technology: definition of the hepatocyte.

scientific article published on June 2005

Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs".

scientific article published on 05 March 2011

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

scientific article published on 26 May 2014

Genotoxic effects of the herbicides alachlor, atrazine, pendimethaline, and simazine in mammalian cells

scientific article published on 01 April 1994

Genotoxic risk for humans due to work place exposure to ethylene oxide: remarkable individual differences in susceptibility.

scientific article published on January 1994

Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype

Glutathione S-transferase T1 and M1 gene defects in ovarian carcinoma

scientific article

Glutathione, glutathione S-transferase alpha and pi, and aldehyde dehydrogenase content in relationship to drug resistance in ovarian cancer

scientific article published on 01 April 1997

Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.

scientific article published on 26 June 2017

Glycerophospholipid profile in oncogene-induced senescence

scientific article

Glycolaldehyde causes DNA-protein crosslinks: a new aspect of ethylene oxide genotoxicity

scientific article published on 01 January 1994

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

scientific article published on January 2004

Handedness and the X chromosome: the role of androgen receptor CAG-repeat length

scientific article

Heavy metal status and oxidative stress in diesel engine tuning workers of central Indian population

scientific article published in November 2007

Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo.

scientific article

Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction.

scientific article published in January 2005

Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis

scientific article published on 28 January 2016

High exposure to inorganic arsenic by food: the need for risk reduction

scientific article

High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines

scientific article published on 01 February 1997

Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing

article

How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis.

scientific article published on 17 June 2014

Human Hepatocytes: Isolation, Culture, and Quality Procedures

article

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

scientific article

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

scientific article

Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy.

scientific article published in May 2005

IGKC and prognosis in breast cancer

scientific article published on 11 December 2012

Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer

scientific article published on 27 September 2017

Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry

scientific article published on 4 January 2016

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

scientific article published on 4 November 2015

Identification of interactions of binary variables associated with survival time using survivalFS

scientific article published on 29 January 2019

Identification of sample annotation errors in gene expression datasets

scientific article

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.

scientific article

Immunoglobulin kappa C predicts overall survival in node-negative breast cancer

scientific article

Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors.

scientific article published on October 2012

Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study

scientific article published on 14 March 2022

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy

scientific article

Improvements in algorithms for phenotype inference: the NAT2 example

scientific article

In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens.

scientific article published in January 2012

In vitro cultured islet-derived progenitor cells of human origin express human albumin in severe combined immunodeficiency mouse liver in vivo

scientific article published in January 2004

In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice.

scientific article published on 23 July 2009

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.

scientific article

Increase in DNA single-strand break rejoining by continuous exposure of human mononuclear blood cells to radioiodine ((131)I) in vitro

scientific article published on 01 November 1997

Increased polysialic acid neural cell adhesion molecule expression in human hippocampus of heroin addicts.

scientific article published on 23 January 2006

Indication for joint replacement and glutathione s-transferases M1 and T1 genotypes.

scientific article

Induction and control of oxidative stress.

scientific article published in December 2007

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity

scientific article published on November 2006

Influence of several solutions used in bypass surgery on the permeability of the endothelium of carotid arteries in New Zealand rabbits

scientific article published in August 1999

Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells.

scientific article

Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.

scientific article published on 7 November 2017

Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects

scientific article published on 07 April 2020

Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response

scientific article

International symposium on control mechanisms of carcinogenesis. September 1995, Mainz, Germany

scientific article

Invitation to an open scientific discussion

scientific article published on 01 January 2015

Isolation of fibroblasts for coating of meshes for reconstructive surgery: differences between mesh types

scientific article published on 01 March 2009

Isolation, identification and toxicological characterization of TSS 1, a new mycotoxin of the rosenane class

scientific article published on 01 March 1990

Kinetic studies on the aggregation of Aspergillus niger conidia.

scientific article published in July 2004

Lack of mutagenic and co‐mutagenic effects of magnetic fields during magnetic resonance imaging ⬇️

scientific article published on December 1, 2001

Left-Right Axis Differentiation and Functional Lateralization: a Haplotype in the Methyltransferase Encoding Gene SETDB2 Might Mediate Handedness in Healthy Adults.

scientific article published on 16 November 2015

Lineage-specific regulation of epigenetic modifier genes in human liver and brain

scientific article

Long term cultures of primary human hepatocytes as an alternative to drug testing in animals.

scientific article published in January 2009

Loss of DNA damage checkpoint genes: switch from preferential induction of point mutations to chromosomal damage precedes the transition towards an aggressive cancer type

scientific article

Loss of circadian clock gene expression is associated with tumor progression in breast cancer.

scientific article

Loss of tumor suppressor protein PTEN during renal carcinogenesis

scientific article

Low-dose extrapolation in toxicology: an old controversy revisited

scientific article published on 01 March 2009

Lysophosphatidylethanolamine is - in contrast to - choline - generated under in vivo conditions exclusively by phospholipase A2 but not by hypochlorous acid

scientific article

Manufactured nanomaterials: categorization and approaches to hazard assessment

scientific article

Mathematical modelling of liver regeneration after intoxication with CCl(4).

scientific article published on 2 February 2007

Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars.

scientific article published in January 2005

Mechanisms of telomere maintenance and attrition: linking cancer and ageing

scientific article published on 01 May 2009

Metabolic detoxification: implications for thresholds.

scientific article

Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway

scientific article

Metabolism of propafenone and verapamil by cryopreserved human, rat, mouse and dog hepatocytes: comparison with metabolism in vivo.

scientific article published on 4 March 2004

Micro-Raman detection of nuclear membrane lipid fluctuations in senescent epithelial breast cancer cells

scientific article published in May 2010

Micro-brushing-based technique to gain fresh urothelial cells for gene expression analysis

scientific article published on 11 July 2017

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 3 February 2016

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits.

scientific article published on 16 November 2010

Miners compensated for pneumoconiosis and glutathione s-transferases M1 and T1 genotypes

scientific article published on 01 January 2012

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

scientific article

Modeling hepatic osteodystrophy in Abcb4 deficient mice

scientific article

Modified cryopreservation and xenotransplantation of human parathyroid tissue

scientific article published on 01 June 1999

Modular microfluidic system for emulation of human phase I/phase II metabolism

scientific article published on 5 March 2014

Modulating Portal Hemodynamics With Vascular Ring Allows Efficient Regeneration After Partial Hepatectomy in a Porcine Model

scientific article published in February 2017

Molecular modes of action of artesunate in tumor cell lines.

scientific article published in August 2003

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

scientific article published on 13 August 2013

Most cited articles in the Archives of Toxicology: the debate about possibilities and limitations of in vitro toxicity tests and replacement of in vivo studies

scientific article published on 01 December 2008

Most cited articles: ethanol-induced hepatotoxicity, anticarcinogenic effects of polyphenolic compounds in tea, dose-response modeling, novel roles of epoxide hydrolases and arsenic-induced suicidal erythrocyte death

scientific article published on 01 December 2011

Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets

scientific article published on 11 May 2006

Mutation analysis of the cationic trypsinogen gene in patients with pancreatic cancer

scientific article published on 01 September 2000

N-Acetyltransferase 2 and glutathione s-transferase M1 in colon and rectal cancer cases from an industrialized area

scientific article published on January 2012

N-acetyltransferase 1*10 genotype in bladder cancer patients

scientific article published on 11 July 2017

NAT2 and bladder cancer--letter

scientific article

Nanotoxicology and oxidative stress control: cutting-edge topics in toxicology

scientific article published on 01 November 2012

Natural Killer Cells and Liver Fibrosis

scientific article

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.

scientific article published on 7 May 2015

New prognostic and predictive factors in breast cancer

scientific article published on December 1, 2010

No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI

scientific article published on 01 May 2003

Nuclear expression of apurinic/apyrimidinic endonuclease increases with progression of ovarian carcinomas

scientific article published on 01 February 2004

Occupational bladder cancer: Polymorphisms of xenobiotic metabolizing enzymes, exposures, and prognosis

scientific article published on 11 July 2017

Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected.

scientific article published in January 2003

Occupational risk factors for prostate cancer in an area of former coal, iron, and steel industries in Germany. Part 2: results from a study performed in the 1990s.

scientific article published on January 2016

Occupational risk factors for relapse-free survival in bladder cancer patients

scientific article published on January 2016

Optimal strategies for sequential validation of significant features from high-dimensional genomic data

scientific article

Optimality in the zonation of ammonia detoxification in rodent liver.

scientific article published on 5 October 2015

Oxidative stress and hepatic carcinogenesis: new insights and applications

scientific article published in February 2010

Oxidative stress: from modification of cell-cycle related events, secondary messenger function, dysregulation of small GTPases, protein kinases and phosphatases to redox-sensitive cancer models

scientific article published on 01 May 2008

P21(Waf1/Cip1) depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway.

scientific article

P2Y1 receptors inhibit both strength and plasticity of glutamatergic synaptic neurotransmission in the rat prefrontal cortex

scientific article published in September 2005

PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness

scientific article

Pathways of proliferation and antiapoptosis driven in breast cancer stem cells by stem cell protein piwil2.

scientific article

Perfluorinated compounds (PFC) hit the headlines : meeting report on a satellite symposium of the annual meeting of the German Society of Toxicology

scientific article published on 9 August 2007

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

scientific journal article

Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice.

scientific article published on October 2010

Phenotype of single hepatocytes expressing an activated version of β-catenin in liver of transgenic mice

scientific article published on 06 August 2011

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

scientific article published on 24 July 2017

Polymorphic enzymes, urinary bladder cancer risk, and structural change in the local industry

scientific article published on 01 January 2012

Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.

scientific article

Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary

scientific article published on 11 July 2017

Possible mutagenic effects of magnetic fields

scientific article

Predicting drug metabolism-dependent toxicity

scientific article published on 01 July 2009

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

scientific article published on 27 June 2019

Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells.

scientific article published on February 2005

Present status and perspectives of cell-based therapies for liver diseases

scientific article

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

scientific article published on January 2007

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

scientific article published in November 2006

Primary rat hepatocytes as in vitro system for gene expression studies: comparison of sandwich, Matrigel and 2D cultures.

scientific article

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System.

scientific article published on 30 May 2015

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

scientific article

Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer.

scientific article published in September 2008

Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients

scientific article

Prognostic influence of pre-operative C-reactive protein in node-negative breast cancer patients

scientific article

Prognostic significance of interferon regulating factor 4 (IRF4) in node-negative breast cancer.

scientific article

Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)

scientific article published on 01 September 2003

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis

scientific article published on 19 April 2014

Pyrethroid insecticide neurotoxicity ⬇️

scientific article published on March 1, 2012

Quantitative analysis of VEGF-isoforms in head and neck squamous cell carcinoma cell lines: relation to xenotransplantability and tumour progression in mice.

scientific article published on September 2002

RE: Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms

scientific article published on 07 February 2016

Re: Caroline E. Weibull, Sandra Eloranta, Daniel Altman, Anna L.V. Johansson, Mats Lambe. Childbearing and the risk of bladder cancer: a nationwide population-based cohort study. Eur Urol 2013;63:733-8.

scientific article

Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.

scientific article

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Recent developments in nanotoxicology.

scientific article published in June 2013

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes

scientific article

Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide- but not from ethylene oxide-induced DNA strand breaks.

scientific article published on January 1997

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

scientific article

Reduced ERPs and theta oscillations underlie working memory deficits in Toxoplasma gondii infected seniors

scientific article

Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk

scientific article published on 13 November 2013

Regenerative capacity differs between micro- and macrovesicular hepatic steatosis

scientific article published on 14 September 2007

Reply to Moestue et al.: Untangling the contribution of choline metabolism to the metastatic process

article published in the Proceedings of the National Academy of Sciences of the United States of America

Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases α and π, glutathione and aldehyde dehydrogenase ⬇️

scientific article published on June 5, 1998

Response to “The Path Forward on Endocrine Disruptors Requires Focus”.

scientific article published in February 2016

Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix-mediated manipulation of signaling activities

scientific article

Ribotoxic stress by mycotoxins

scientific article published on 01 September 2010

Role of the progesterone receptor for paclitaxel resistance in primary breast cancer.

scientific article published on 9 January 2007

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer

scientific article

Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk.

scientific article published on 25 April 2012

Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk.

scientific article

SPOC1, a novel PHD-finger protein: association with residual disease and survival in ovarian cancer

scientific article published on 01 September 2005

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article published on 5 July 2013

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article published in December 2013

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article

Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

scientific article published in September 2013

Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

scientific article published in October 2013

Second Symposium on Interdisciplinary Activities in Environmental Toxicology in North Rhine-Westphalia, Germany: part two.

scientific article published in January 2012

Second symposium on Environmental Toxicology in North Rhine-Westphalia, Germany-interdisciplinary research activities in toxicology, statistics, hygiene and medicine: meeting report on a symposium held in Dortmund May 19-20, 2011.

scientific article published on 6 February 2013

Second symposium on interdisciplinary activities in environmental toxicology in North Rhine-westphalia, Germany

scientific article

Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole

scientific article published on 7 March 2007

Selenium: an element with two faces

scientific article published on 01 December 2011

Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex.

scientific article

Severe arsenic poisoning: one of the largest man-made catastrophies

scientific article published on 01 August 2010

Size of pancreatic islets of Langerhans: a key parameter for viability after cryopreservation.

scientific article

Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer--what limits limited disease?

scientific article published on September 2002

Standard compounds for establishment of in vitro test systems

scientific article published on 01 December 2014

Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung

scientific article published in 2022

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

scientific article published on 21 December 2016

Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.

scientific article

Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit

Subtype-specific prognostic impact of different immune signatures in node-negative breast cancer.

scientific article published on 05 June 2017

Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure

scientific article published in November 2009

Switching off HER-2/neu in a tetracycline-controlled mouse tumor model leads to apoptosis and tumor-size-dependent remission.

scientific article published on November 2003

Systems biology meets toxicology

scientific article published on 01 August 2012

TGF-β1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia

scientific article

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

scientific article published on 01 January 2019

Test systems of developmental toxicity: state-of-the art and future perspectives.

scientific article published in December 2013

Testing of genetically modified novel proteins for allergenicity in food and feed: a toxicological and regulatory challenge

scientific article published on 01 December 2010

The Met-genotype of the BDNF Val66Met polymorphism is associated with reduced Stroop interference in elderly

scientific article published on 3 October 2012

The REACH concept and its impact on toxicological sciences

scientific article published on 01 March 2006

The ascending pathophysiology of cholestatic liver disease.

scientific article published on 16 December 2016

The carcinogenicity debate on formaldehyde: How to derive safe exposure limits?

scientific article published on 01 June 2010

The dilemma of cultivated hepatocytes

scientific article published in February 2009

The functional tumor necrosis factor-α (308A/G) polymorphism modulates attentional selection in elderly individuals

scientific article published on 11 May 2013

The humoral immune system has a key prognostic impact in node-negative breast cancer

scientific article published on 01 July 2008

The nanotoxicology revolution

scientific article

The past and the future of toxicology

scientific article

The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer

scientific article

The proteasome inhibitor Bortezomib (Velcade) as potential inhibitor of estrogen receptor-positive breast cancer.

scientific article published on 8 January 2015

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

scientific article published on 20 April 2014

The ultra-slow NAT2*6A haplotype is associated with reduced higher cognitive functions in an elderly study group.

scientific article published on 28 November 2015

The virtual liver: state of the art and future perspectives

scientific article

Third Symposium on Interdisciplinary Activities in Environmental Toxicology in North Rhine-Westphalia, Germany

scientific article published on 23 June 2017

Third symposium on Environmental Toxicology in North Rhine-Westphalia, Germany: Interdisciplinary Research Activities in Toxicology, Statistics, Hygiene and Medicine : Meeting report on a symposium held in Dortmund May 7-8, 2015.

scientific article published on 13 October 2017

TiQuant: software for tissue analysis, quantification and surface reconstruction.

scientific article published on 3 June 2015

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

scientific article published on 28 November 2019

Toxicogenomics directory of chemically exposed human hepatocytes

scientific article

Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide ⬇️

scientific article published on April 9, 2013

Toxoplasma gondii impairs memory in infected seniors.

scientific article published on 7 December 2013

Tracking of human cells in mice.

scientific article

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

scientific article published on 26 October 2010

Transcriptomics of Hepatocytes Treated with Toxicants for Investigating Molecular Mechanisms Underlying Hepatotoxicity

scientific article published in January 2015

Transient increase in DNA strand breaks in car refinishing spray painters.

scientific article published on December 1996

Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: influence on tumour development in an ERBB2-dependent mouse tumour model

scientific article published on 29 April 2008

Tumor cell specific toxicity of Inula helenium extracts.

scientific article published on November 2006

Ultra-slow N-Acetyltransferase 2 Is Associated with Recurrence-free Time in Bladder Cancer Patients

scientific article published on 28 December 2016

Unique metabolic features of stem cells, cardiomyocytes, and their progenitors.

scientific article published on April 2014

Urinary bladder cancer risk factors in an area of former coal, iron, and steel industries in Germany

scientific article published on 11 July 2017

Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene

scientific article published on 03 September 2011

Urinary cadmium levels in active and retired coal miners

scientific article published on 11 July 2017

Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: repeated administrations of acetaminophen reduces albumin and urea secretion

scientific article published on 01 January 2007

Vasopressin induces opposite changes in blood flow in the skin and the muscular circulation

scientific article published on 01 January 1998

Water-soluble rylene dyes as high-performance colorants for the staining of cells.

scientific article

[Bladder cancer at an early age in father and son]

scientific article published on 01 December 2011

[Cryotherapy of malignant tumors: studies with MRI in an animal experiment and comparison with morphological changes]

scientific article published on 01 July 2001

[Hereditary pancreatitis - a clinically relevant cause of pancreatic adenocarcinoma?]

scientific article published on 01 November 2001

[Local pulse pressure and regression of arterial wall hypertrophy during antihypertensive treatment. CELIMENE study. The Celiprolol Intima-Media Enalapril Efficacy study]

scientific article published on 01 August 2000

[Procedures for determining occupational diseases in cases of urological disorders]

scientific article published on 01 September 2008

[Secondary neoplasia after immunosuppression]

scientific article published on 01 December 1994

c-erbB-2 expression in small-cell lung cancer is associated with poor prognosis.

scientific article published in May 2001

c-kit expression in adenocarcinomas of the lung.

scientific article

cAMP-dependent phosphorylation of CYP2B1 as a functional switch for cyclophosphamide activation and its hormonal control in vitro and in vivo.

scientific article published in December 2001

mdm 2 mRNA expression is associated with survival in ovarian cancer

scientific article

Paulina is supported by:

About Paulina

Help