List of works - Lars Olsen

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

scientific article published on August 2013

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

scientific article

A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures.

scientific article published on 5 October 2015

Biophysical characterization of the proton-coupled oligopeptide transporter YjdL.

scientific article published on 23 August 2012

Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH.

scientific article published on 12 July 2016

Cytochrome P450-mediated metabolism of the synthetic cannabinoids UR-144 and XLR-11

scholarly article by Line Marie Nielsen et al published 11 September 2015 in Drug Testing and Analysis

Density functional theory study on the formation of reactive benzoquinone imines by hydrogen abstraction.

scientific article

Dissecting the Cytochrome P450 1A2- and 3A4-Mediated Metabolism of Aflatoxin B1 in Ligand and Protein Contributions

scientific article published on 12 January 2017

Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling.

scientific article published on 18 March 2016

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.

scientific article published on June 2016

In memory of Patrik Rydberg

scientific article

Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

scientific article

Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions.

scientific article

Mechanism of the N-Hydroxylation of Primary and Secondary Amines by Cytochrome P450

Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450.

scientific article

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

scientific article published on 10 December 2015

Prediction of cytochrome P450 mediated metabolism

scientific article published on 06 May 2015

Prediction of pKa Values for Druglike Molecules Using Semiempirical Quantum Chemical Methods

scientific article published on 5 January 2017

Salt Bridge Swapping in the EXXERFXYY Motif of Proton-coupled Oligopeptide Transporters

scientific article

Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

scientific article

Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors.

scientific article published on 28 February 2017

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

scientific article

Synthesis and chemical characterization of several perfluorinated sialic acid glycals and evaluation of their in vitro antiviral activity against Newcastle disease virus

scientific article published on 05 June 2017

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

scientific article

The CYP79A1 catalyzed conversion of tyrosine to (E)-p-hydroxyphenylacetaldoxime unravelled using an improved method for homology modeling.

scientific article

The contribution of atom accessibility to site of metabolism models for cytochromes P450.

scientific article published on 22 January 2013

Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces

scientific article published on 9 December 2014

List of works by Lars Olsen

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures.

Biophysical characterization of the proton-coupled oligopeptide transporter YjdL.

Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH.

Cytochrome P450-mediated metabolism of the synthetic cannabinoids UR-144 and XLR-11

Density functional theory study on the formation of reactive benzoquinone imines by hydrogen abstraction.

Dissecting the Cytochrome P450 1A2- and 3A4-Mediated Metabolism of Aflatoxin B1 in Ligand and Protein Contributions

Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling.

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.

In memory of Patrik Rydberg

Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions.

Mechanism of the N-Hydroxylation of Primary and Secondary Amines by Cytochrome P450

Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450.

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

Prediction of cytochrome P450 mediated metabolism

Prediction of pKa Values for Druglike Molecules Using Semiempirical Quantum Chemical Methods

Salt Bridge Swapping in the EXXERFXYY Motif of Proton-coupled Oligopeptide Transporters

Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors.

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

Synthesis and chemical characterization of several perfluorinated sialic acid glycals and evaluation of their in vitro antiviral activity against Newcastle disease virus

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

The CYP79A1 catalyzed conversion of tyrosine to (E)-p-hydroxyphenylacetaldoxime unravelled using an improved method for homology modeling.

The contribution of atom accessibility to site of metabolism models for cytochromes P450.

Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces