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List of works by Jette S Kastrup

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation

scientific article published on 16 February 2018

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

scientific article

A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study

scientific article published on 15 August 2005

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

scientific article (publication date: May 2007)

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

scientific article

A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure

scientific article

A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures.

scientific article published on 5 October 2015

A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

scientific article

A pharmacological profile of the high-affinity GluK5 kainate receptor.

scientific article published on 29 June 2016

A tetrazolyl-substituted subtype-selective AMPA receptor agonist

scientific article

A unique set of SH3-SH3 interactions controls IB1 homodimerization

scientific article

Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

scientific article

Atomic resolution structure of human HBP/CAP37/azurocidin

scientific article

Binding mode of an α-amino acid-linked quinoxaline-2,3-dione analogue at glutamate receptor subtype GluK1

scientific article

Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2

scientific article published on 15 June 2020

Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate

scientific article

Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

scientific article

Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

scientific article

Crystal Structure and Pharmacological Characterization of a Novel N-Methyl-D-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site

scientific article

Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism

scientific article

Crystal Structure of a Partly Self-Complementary Peptide Nucleic Acid (PNA) Oligomer Showing a Duplex−Triplex Network†

scientific article (publication date: February 2005)

Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

scientific article published on 04 November 2018

Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

scientific article

Crystal structure of tetranectin, a trimeric plasminogen‐binding protein with an α‐helical coiled coil ⬇️

scientific article published on July 28, 1997

Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping

scientific article

Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

scientific article published in February 2005

Crystal structures of two peptide–HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype

scientific article published on 18 October 2006

Crystallization and molecular-replacement solution of a truncated form of human recombinant tetranectin

scientific article published on 01 May 2000

Crystallization and preliminary X-ray analysis of a PNA-DNA complex

scientific article published on 01 April 1995

Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1

scientific article published on 22 December 2016

Dimerization effect of sucrose octasulfate on rat FGF1

scientific article

Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

scientific article

Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface.

scientific article published on 13 January 2015

Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds

scientific article published on 08 June 2018

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.

scientific article published on June 2016

Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

article published in 2011

Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP.

scientific article published on April 2005

Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1.

scientific article published on 25 February 2004

Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1

scientific article published on 31 August 2005

Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine

scientific article

GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists

scientific article

High resolution crystal structures of the p120 RasGAP SH3 domain

scientific article

High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide

scientific article published on 20 July 2005

Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

scientific article published on 30 March 2017

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

scientific article

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine  4 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED

scientific article

Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering.

scientific article published on 27 November 2017

Ionotropic glutamate-like receptor  2 binds D-serine and glycine

scientific article

Kainate induces various domain closures in AMPA and kainate receptors

scientific article

L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

scientific article

Lessons from crystal structures of kainate receptors

scientific article published on 25 May 2016

Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides.

scientific article

Lipopolysaccharide affinity measurement by scintillation proximity assay: application to human heparin binding protein

scientific article published on 01 February 2000

Measurement of apoptosis by the TUNEL method using scintillating microplates.

scientific article

Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium

scientific article

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

scientific article published on 10 December 2012

Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

scientific article

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

scientific article

Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand binding domain

scientific article

N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo P

scientific article published on 31 October 2019

N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology

scientific article published on 23 January 2019

Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

scientific article

Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

scientific article published on 13 January 2010

Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

scientific article

Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

scientific article

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

scientific article published on 10 December 2015

Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface

scientific article published in 2024

Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis.

scientific article published on March 2004

Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization

scientific article

Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

scientific article

Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.

scientific article

Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

scientific article

Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors

scientific article

Structural basis of cell-cell adhesion by NCAM

scientific article

Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family

scientific article

Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

scientific article

Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion.

scientific article published on 21 September 2006

Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.

scientific article published on 10 July 2017

Structure and Interactions of NCAM Ig1-2-3 Suggest a Novel Zipper Mechanism for Homophilic Adhesion ⬇️

scientific article published on October 1, 2003

Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP.

scientific article

Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue.

scientific article published on 4 November 2006

Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

scientific article

Structure of rat acidic fibroblast growth factor at 1.4 Å resolution

scientific article

Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom.

scientific article

Structure of the C-Type Lectin Carbohydrate Recognition Domain of Human Tetranectin ⬇️

scientific article published on September 1, 1998

Structure of the first PDZ domain of human PSD-93

scientific article

Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity

scientific article

Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

scientific article

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency

scientific article

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

scientific article

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

scientific article

Studies on an ( S )-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural Characterization

scientific article

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors

scientific article

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

scientific article

Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists

scientific article

The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure

scientific article published on December 2005

The Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

scientific article

The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove

scientific article

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

scientific article

The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals

scientific article

The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.

scientific article published on 7 April 2017

The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.

scientific article published on 31 January 2006

The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit

scientific article

The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1.

scientific article

Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces

scientific article published on 9 December 2014

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

scientific article

Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues

scientific article

Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

scientific article published on 29 October 2013

Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.

scientific article published on 9 December 2004

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

scientific article published on 18 April 2019

Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B.

scientific article

X-ray structure of the 154-amino-acid form of recombinant human basic fibroblast growth factor. comparison with the truncated 146-amino-acid form.

scientific article published on March 1997

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