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List of works by Takamitsu Hosoya

(Hexafluoroacetylacetonato)copper(I)-cycloalkyne complexes as protected cycloalkynes

scientific article published on 27 August 2020

1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination.

scientific article

11C-cetrozole: an improved C-11C-methylated PET probe for aromatase imaging in the brain.

scientific article published on 27 March 2014

2-Azidoacrylamides as compact platforms for efficient modular synthesis

scientific article published on 26 November 2020

3-Azidodifluoromethyl-3H-diazirin-3-yl group as an all-in-one functional group for radioisotope-free photoaffinity labeling

scientific article published on 15 August 2007

3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

scientific article published on 25 June 2019

A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach

scientific article published on 01 March 2019

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates

scientific article published on 08 October 2015

A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.

scientific article published in November 2010

A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation.

scientific article published on 28 September 2017

An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether

scientific article published on 01 June 2015

An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

scientific article published on 01 December 2014

Application of new semisynthetic aequorins with long half-decay time of luminescence to G-protein-coupled receptor assay ⬇️

scientific article published on August 25, 2010

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

scientific article published on 22 November 2016

Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations

scientific article published on 24 December 2020

Association between aromatase in human brains and personality traits

scientific article published in Scientific Reports

Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[18F]fluoro- and 10-O-p-[11C]methylbenzyl ginkgolide B in monkey and rat brains

scientific article

Boracene-based alkylborate enabled Ni/Ir hybrid catalysis

scientific article published on 19 August 2020

Boron-selective biaryl coupling approach to versatile dibenzoxaborins and application to concise synthesis of defucogilvocarcin M.

scientific article

C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase.

scientific article published on 18 June 2013

CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia

scientific article

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

scientific article

Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

scientific article

Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin

scientific article published on 11 June 2021

Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A

scientific article published on 01 March 2008

Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.

scientific article published on 21 September 2017

Concise Synthesis of v-Coelenterazines

scientific article published on 21 July 2015

Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles

scientific article published on 24 February 2020

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

scientific article

Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit

scientific article published on 05 January 2021

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

scientific article published on 12 March 2018

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes.

scientific article

Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine

scientific article

Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle.

scientific article published in March 2003

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

scientific article published on 14 June 2015

Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle.

scientific article published in March 2005

Detection of structural changes in a cofactor binding protein by using a wheat germ cell-free protein synthesis system coupled with unnatural amino acid probing

scientific article published in May 2007

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

scientific article

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

scientific article

Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation

scientific article published in November 2013

Direct thioamination of arynes via reaction with sulfilimines and migratory N-arylation

scientific article published on 3 November 2015

Enhanced clickability of doubly sterically-hindered aryl azides.

scientific article published on 5 September 2011

Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: comparison of substrate specificity for C2-modified coelenterazines

scientific article published on 27 December 2012

Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S,S-dioxide moiety and two azido groups

scientific article published on 26 March 2020

Further enhancement of the clickability of doubly sterically-hindered aryl azides by para-amino substitution

article

Generation of arynes via ate complexes of arylboronic esters with an ortho-leaving group

scientific article published on 21 May 2013

Generation of cycloheptynes and cyclooctynes via a sulfoxide-magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates

scientific article published on 01 May 2015

Hydrosilyl Group-directed Iridium-catalyzed peri-Selective C–H Borylation of Ring-fused (Hetero)Arenes

scholarly article by Yuto Sumida et al published 5 October 2018 in Chemistry Letters

IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys

scientific article published on 25 December 2013

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

scientific article published on 3 August 2015

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

scientific article

Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole.

scientific article published in May 2011

Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation

scientific article published on 03 July 2020

Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

scientific article published on April 2002

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.

scientific article

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system ⬇️

scientific article published on May 27, 2013

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

scientific article published on 03 December 2018

Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions.

scientific article published on 31 January 2014

Manipulation of alternative splicing by a newly developed inhibitor of Clks

scientific article (publication date: 4 June 2004)

Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide-aryne and azide-alkyne cycloadditions

scientific article published on 01 October 2014

Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study

scientific article published on 28 September 2006

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

scientific article published on 03 November 2015

PET of Aromatase in Gastric Parietal Cells Using 11C-Vorozole ⬇️

scientific article published on November 9, 2011

Palladium(0)-mediated rapid methylation and fluoromethylation on carbon frameworks by reacting methyl and fluoromethyl iodide with aryl and alkenyl boronic acid esters: useful for the synthesis of [11C]CH(3)--C- and [18F]FCH2--C-Containing PET trace

scientific article published in January 2009

Palladium(ii)-mediated rapid C-cyanation of (hetero)arylborons

scientific article published on 05 October 2018

Palladium-catalyzed regio- and stereoselective hydrosilylation of electron-deficient alkynes

scientific article published on 23 February 2012

Pd(0)-Mediated rapid coupling between methyl iodide and heteroarylstannanes: an efficient and general method for the incorporation of a positron-emitting (11)C radionuclide into heteroaromatic frameworks.

scientific article published in November 2009

Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes

scientific article published in June 2014

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.

scientific article published on 5 September 2017

Preparation of Aryne–Nickel Complexes from ortho-Borylaryl Triflates

scientific article published on 17 October 2016

Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.

scientific article published on 5 April 2018

Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group.

scientific article

Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene

scientific article

Reconstitution of blue fluorescent protein from recombinant apoaequorin and synthetic coelenteramide.

scientific article published on 21 June 2009

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

scientific article

Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids.

scientific article published on 26 January 2017

Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-S Bond Cleavage.

scientific article published on 23 May 2016

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates.

scientific article published on 18 September 2017

Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039.

scientific article published on 21 August 2015

Selective inhibition of the kinase DYRK1A by targeting its folding process

scientific article (publication date: 22 April 2016)

Selective strain-promoted azide-alkyne cycloadditions through transient protection of bicyclo[6.1.0]nonynes with silver or gold

scientific article published on 27 July 2020

Single C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group

scientific article published on 17 June 2016

Single C-F Transformations of o-Hydrosilyl Benzotrifluorides with Trityl Compounds as All-in-One Reagents

scientific article published on 12 November 2020

Site-selective post-translational modification of proteins using an unnatural amino acid, 3-azidotyrosine

scientific article published on 3 January 2007

Site-specific attachment of a protein to a carbon nanotube end without loss of protein function

scientific article published on 02 July 2012

Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin

scholarly article by Satoshi Inouye published in May 2018

Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia ⬇️

scientific article published on January 25, 2002

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

scientific article published on 01 July 2018

Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N-Dimethylformamide

scientific article published on 11 November 2016

Substituted 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctenes: syntheses, properties, and DFT studies of substituted Sondheimer-Wong diynes

scientific article published on 25 November 2014

Sulfoxide synthesis from sulfinate esters under Pummerer-like conditions

scientific article published on 14 April 2020

Synthesis of (2,2-Diborylvinyl)arenes by Rhodium-Catalyzed Desulfanylative gem-Diborylation of 2-Arylvinyl Sulfides

scientific article published on 24 June 2019

Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates

scientific article published on 19 April 2019

Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborins

scientific article published on 11 August 2020

Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory O-Arylation

scientific article published on 06 October 2017

Synthesis of Diverse γ-Aryl-β-ketoesters via Aryne Intermediates Generated by C-C Bond Cleavage

scientific article published on 24 October 2019

Synthesis of Functionalized Benzopyran/Coumarin-Derived Aryne Precursors and Their Applications

scientific article published on 13 October 2020

Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents

scientific article published on 11 July 2017

Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

scientific article published on 22 April 2020

Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes

scientific article published on 28 May 2020

The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly

scientific article

The mevalonate pathway regulates primitive streak formation via protein farnesylation

scientific article

Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation

scientific article published on 13 November 2020

Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles.

scientific article published on 25 August 2016

Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon-Carbon Bond Cleavage

scientific article published on 23 February 2017

Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision.

scientific article published on 23 June 2017

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

scientific article published on 14 June 2018

Transient protection of strained alkynes from click reaction via complexation with copper

scientific article published on 19 September 2014

Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper

scientific article published on 23 October 2020

Unconventional secretion of the mutated 19 kDa protein of Oplophorus luciferase (nanoKAZ) in mammalian cells

scientific article published on 11 July 2014

[35S]S-[5-(4-benzoylphenyl)pentyl]glutathione: a versatile radioligand targeting GS-X pumps with the ability of photoaffinity labeling

scientific article published in September 1999

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