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List of works by Brian Hemmings

12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer

scientific article published on 01 December 1996

36 Glycogen synthase kinase-3 from rabbit skeletal muscle

scientific article published on 01 January 1983

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

scientific article

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

scientific article

AGC kinases in cancer metastasis, immune checkpoint regulation and drug resistance

scientific article published in February 2018

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

scientific article

AKT-ions with a TWIST between EMT and MET

scientific article

Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

scientific article

Abnormal expression of the RI subunit of cyclic AMP-dependent protein kinase in Y-79 retinoblastoma cells

scientific article published on 01 April 1989

Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.

scientific article published on 3 September 2012

Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling

scientific article published on July 2016

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

scientific article published on June 1996

Activation of cAMP-dependent protein kinase alters the chromatin structure of the urokinase-type plasminogen activator gene promoter

scientific article published on February 1994

Activation of protein kinase B induced by H(2)O(2) and heat shock through distinct mechanisms dependent and independent of phosphatidylinositol 3-kinase

scientific article published on 01 December 1999

Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development

scientific article

Advances in protein kinase B signalling: AKTion on multiple fronts

scientific article published on May 2004

Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage

scientific article published on 5 December 2004

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

scientific article published on 25 January 2012

Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development

scientific article

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.

scientific article published on 21 June 2013

Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development

scientific article published in February 2015

Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation

scientific article published on 11 October 2006

Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization

scientific article

Analysis of Protein Kinase B/Akt ⬇️

scientific article published on January 1, 2002

Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus ⬇️

scientific article published on April 5, 1993

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

scientific article published on April 2001

Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death.

scientific article

Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI.

scientific article published on July 2010

Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins ⬇️

scientific article published on October 15, 1998

Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis

scientific article

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

scientific article

Centrosome-associated NDR kinase regulates centrosome duplication

scientific article published on February 2007

Characterisation of a Reconstituted Mg-ATP-Dependent Protein Phosphatase ⬇️

scientific article published on June 15, 1983

Characterization of fragmented 3-phosphoinsitide-dependent protein kinase-1 (PDK1) by phosphosite-specific antibodies.

scientific article

Characterization of two mutants of the LLC-PK1 porcine kidney cell line affected in the catalytic subunit of the cAMP-dependent protein kinase

scientific article published on 01 April 1987

Chronic Akt1 deficiency attenuates adverse remodeling and enhances angiogenesis after myocardial infarction.

scientific article published on 17 October 2013

Codominant expression of a mutation affecting the cAMP-dependent protein kinase catalytic subunit in somatic cell hybrids of LLC-PK1 cells

scientific article published on May 1988

Complementation between LLC-PK1 mutants affected in polypeptide hormone-receptor function

scientific article published on February 1987

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry

scientific article published on 21 June 2012

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells ⬇️

scientific article published on July 1, 1998

Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase

scientific article published on October 1996

Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation

scientific article published in August 2003

Correspondence analysis of microarray time-course data in case-control design

scientific article published in October 2004

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

scientific article

DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif

scientific article

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

scientific journal article

Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.

scientific article

Deletion of PKBalpha/Akt1 affects thymic development

scientific article

Dependence of urokinase-type-plasminogen-activator induction on cyclic AMP-dependent protein kinase activation in LLC-PK1 cells

scientific article

Deregulated signalling networks in human brain tumours

scientific article published on 29 October 2009

Detection of heterologous Gs-coupled receptor activity in LLC-PK1 cells based on expression of urokinase-type plasminogen activator

scientific article published on 01 January 1997

Developmental expression of the RI subunit of cyclic AMP-dependent protein kinase in retina

scientific article published in June 1989

Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase

scientific article published on February 1995

Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.

scientific article

Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.

scientific article

Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin

scientific article published on May 1997

Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression

scientific article

Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k

scientific article published on February 1998

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

scientific article

Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A.

scientific article published in December 2002

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

scientific journal article

Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice

scientific article

Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression.

scientific article published on 15 June 2011

Effect of hypothyroidism and thyroid hormone replacement on the level of protein kinase C and protein kinase A in rat liver

scientific article published on 01 May 1991

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

scientific article

Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.

scientific article

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

scientific article published in June 2005

Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.

scientific article published on 26 June 2008

Expression cloning of a cDNA encoding the type II regulatory subunit of the cAMP-dependent protein kinase

scientific article

Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes

scientific article published in October 2004

From man to mouse and back again: advances in defining tumor AKTivities in vivo.

scientific article published on 12 October 2010

Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

scientific article

G-Protein-coupled Receptors and Fcγ-receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes ⬇️

scientific article published on October 31, 1997

Gonadotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide affect levels of cyclic adenosine 3',5'-monophosphate-dependent protein kinase A (PKA) subunits in the clonal gonadotrope alphaT3-1 cells: evidence for cross-talk

scientific article published on 01 June 1997

Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).

scientific article published on October 2010

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

scientific article

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

scientific article published in Journal of Biological Chemistry

Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation

scientific article

Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.

scientific article

Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2A

scientific article published in March 1996

Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway

scientific article

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

scientific article published on 15 July 2004

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

scientific article published in July 2002

Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP ⬇️

scientific article published on 01 November 1984

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity

scientific article published on 31 July 2001

In search of signaling pathways critical for ovarian graft reception: Akt1 is essential for long-term survival of ovarian grafts

scientific article published in November 2013

In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance

scientific article published on 01 March 2001

In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis

scientific article published on 29 August 2008

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

scientific article

Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy

scientific article published on 8 June 2016

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

scientific article (publication date: December 1995)

Inhibition of protein kinase B/Akt. implications for cancer therapy

scientific article

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

scientific article

Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy

scientific article published on 11 June 2015

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

scientific article

Involvement of the Pleckstrin Homology Domain in the Insulin-stimulated Activation of Protein Kinase B ⬇️

scientific article published on November 6, 1998

Isolation of a cDNA and characterization of the 5' flanking region of the gene encoding the type I regulatory subunit of the cAMP-dependent protein kinase

scientific article

Isolation of a mutant LLC-PK1 cell line defective in hormonal responsiveness. A pleiotropic lesion in receptor function

scientific article published in October 1986

Isolation, characterization, and chromosomal localization of the porcine calcitonin receptor gene. Identification of two variants of the receptor generated by alternative splicing

scientific article published on July 1994

LLC-PK1 cell mutants in cAMP metabolism respond normally to phorbol esters

scientific article published on 01 September 1986

Large-Scale Expression and Purification of a Soluble Form of the Pleckstrin Homology Domain of the Human Protooncogenic Serine/Threonine Protein Kinase PKB (c-Akt) in Escherichia coli

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

scientific article

Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

scientific article

Long-term stimulation of cAMP production in LLC-PK1 pig kidney epithelial cells by salmon calcitonin or a photoactivatable analogue of vasopressin

scientific article

Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo ⬇️

scientific article published on January 24, 2012

MAP Kinase-Interacting Kinase 1 Regulates SMAD2-Dependent TGF-β Signaling Pathway in Human Glioblastoma ⬇️

scientific article published on March 14, 2011

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas

scientific article published on 09 January 2014

Mammalian NDR protein kinases: from regulation to a role in centrosome duplication.

scientific article published on 15 August 2007

Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling

scientific article

Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase

scientific article

Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein

scientific article

Mechanism of activation of protein kinase B by insulin and IGF-1

scientific article

Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase

scientific article

Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer

scientific article

Mechanisms of cAMP-mediated gene induction: examination of renal epithelial cell mutants affected in the catalytic subunit of the cAMP-dependent protein kinase

scientific article published on January 1991

Meeting report: targeting the kinome--20 years of tyrosine kinase inhibitor research in Basel

scientific article published on 20 February 2007

Melatonin synthesis in the bovine pineal gland is regulated by type II cyclic AMP-dependent protein kinase

scientific article published on 01 February 1997

Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme ⬇️

scientific article published on April 2, 2012

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ ⬇️

scientific article published on November 28, 1997

Modulation of PI3K/PTEN Pathway Does Not Affect Catalytic Activity of PDK1 in Jurkat Cells.

scientific article published in October 2017

Modulation of regulatory and catalytic subunit levels of cAMP-dependent protein kinase A in anterior pituitary cells in response to direct activation of protein kinases A and C or after GnRH stimulation

scientific article published on 01 November 1995

Modulation of the Enzymatic Properties of Protein Phosphatase 2A Catalytic Subunit by the Recombinant 65‐kDa Regulatory Subunit PR65α ⬇️

scientific article published on August 15, 1997

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

scientific article (publication date: 16 December 1996)

Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase

scientific article

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily ⬇️

scientific article published on May 15, 1991

Molecular cloning of a second form of rac protein kinase ⬇️

scientific article published on December 1, 1991

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

scientific article

Multimodal imaging reveals a role for Akt1 in fetal cardiac development.

scientific article

Multiple mRNA species code for the catalytic subunit of the cAMP-dependent protein kinase from LLC-PK1 cells. Evidence for two forms of the catalytic subunit

scientific article published in September 1987

Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Phosphorylation of site 5 by glycogen synthase kinase-5 (casein kinase-II) is a prerequisite for phosphorylation of sites 3 by glycogen synthase kinase-3

scientific article published on 01 December 1982

NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development

scientific article

NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis

scientific article

NDR functions as a physiological YAP1 kinase in the intestinal epithelium

scientific article published on 15 January 2015

NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis

scientific article

NDR kinases regulate essential cell processes from yeast to humans

scientific article

Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs

scientific article

Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription

scientific article published on 04 December 2002

Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells

scientific article published on 01 January 1998

Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons

scientific article

Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα-/-) in vivo model

scientific article published on 28 April 2014

Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors

scientific article published in May 2008

Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-Jun

scientific article published on January 1994

Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state

scientific article

Overcoming resistance to rapalogs in gliomas by combinatory therapies ⬇️

scientific article published on 08 February 2013

Overexpression of the alpha-type protein kinase (PK) C in LLC-PK1 cells does not lead to a proportional increase in the induction of two 12-O-tetradecanoylphorbol-13-acetate-inducible genes

scientific article published on June 1991

PH Domain of Serine-Threonine Protein Kinase 6 (RAC–PKB): Expression and Binding Assay for Phosphoinositides and lnositol Phosphates

scientific article published on January 1, 1998

PH domains and phospholipases--a meaningful relationship?

scientific article published on February 1994

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

scientific article

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury.

scientific article

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.

scientific article published on 11 January 2012

PIKKing on PKB: regulation of PKB activity by phosphorylation

scientific article published on 19 March 2009

PKB and the mitochondria: AKTing on apoptosis

scientific article published on 25 July 2007

PKB binding proteins. Getting in on the Akt.

scientific article

PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage ⬇️

scientific article published on September 11, 2012

PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage.

scientific article published on 19 April 2010

PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain.

scientific article published on August 2000

PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis.

scientific article published on 10 September 2014

PKB/Akt-Dependent Regulation of Cell Motility ⬇️

scientific article published on January 25, 2013

PKB/Akt-dependent regulation of inflammation in cancer

scientific article published on 2 May 2017

PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts

scientific article published on 14 February 2006

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

scientific article

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage

scientific article published on 17 November 2008

Pathway of urokinase-type plasminogen activator induction in the T47D and LLC-PK1 cell lines

scientific article published on 01 September 1987

Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors

scientific article published in October 2001

Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control

scientific article published on 17 August 2010

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase ⬇️

scientific article published on August 18, 1998

Phosphorylation and activation of p70s6k by PDK1

scientific article

Phosphorylation of K-casein by glycogen synthase kinase-3 from rabbit skeletal muscle

scientific article published on 01 June 1983

Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease

scientific article published on February 2012

Phosphorylation of the Twist1-Family Basic Helix-Loop-Helix Transcription Factors Is Involved in Pathological Cardiac Remodeling ⬇️

scientific article published on April 29, 2011

Phosphorylation of the Type-II Regulatory Subunit of Cyclic-AMP-Dependent Protein Kinase by Glycogen Synthase Kinase 3 and Glycogen Synthase Kinase 5

scientific article published in 2005

Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.

scientific article

Physiological functions of protein kinase B/Akt

scientific article (publication date: April 2004)

Pleckstrin homology (PH) domains in signal transduction

scientific article (publication date: December 1994)

Pleckstrin homology domains

scientific article published on August 1995

Promiscuous affairs of PKB/AKT isoforms in metabolism.

scientific article published on 10 January 2011

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

scientific article published on January 2010

Protein kinase B alpha/Akt1 regulates placental development and fetal growth

scientific journal article

Protein kinase B beta/Akt2 plays a specific role in muscle differentiation

scientific article published on 21 November 2000

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

scientific article published on June 1999

Protein kinase B/Akt at a glance

scientific article

Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism ⬇️

scientific article published on February 19, 1998

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

scientific article

Protein kinases, from B to C.

scientific article published on November 2007

Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

scientific article published on 01 January 1988

Purification of Glycogen Synthase Kinase 3 from Rabbit Skeletal Muscle.. Copurification with the Activating Factor (FA)of the (Mg-ATP) Dependent Protein Phosphatase ⬇️

scientific article published on 01 October 1981

Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions

scientific article

RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.

scientific article published on 8 May 2003

RFLPs at the porcine locus encoding the type I-alpha regulatory subunit of the cAMP-dependent protein kinase (PRKAR1A).

scientific article

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

scientific article published in Journal of Biological Chemistry

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

scientific article published on May 1999

Recombinant type I regulatory subunit of the cAMP-dependent protein kinase is biologically active

scientific article published on 01 August 1987

Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism ⬇️

scientific article published on December 27, 1982

Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.

scientific article published on 24 June 2014

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

scientific article published on 25 July 2001

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding

scientific article published on 16 November 2007

Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

scientific article

Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein

scientific article

Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis.

scientific article

Regulation of cAMP-dependent protein kinase in cultured cells.

scientific article published in January 1985

Regulation of protein kinase B.

scientific article

Regulation of protein kinase cascades by protein phosphatase 2A.

scientific article

Role of protein phosphatase 2A in the regulation of mitogen-activated protein kinase activity in ventricular cardiomyocytes

scientific article published on 01 April 1996

Role of translocation in the activation and function of protein kinase B

scientific journal article

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt ⬇️

scientific article published on January 1, 2012

SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment.

scientific article published in February 2018

Separation and characterisation of glycogen synthase kinase 3, glycogen synthase kinase 4 and glycogen synthase kinase 5 from rabbit skeletal muscle

scientific article published on 01 May 1982

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

scientific article

Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response

scientific journal article

Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

scientific article

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

scientific article published on 28 May 2004

Staurosporine stimulates expression of the urokinase-type (u-PA) plasminogen activator in LLC-PK1 cells

scientific article published on 01 November 1989

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing

scientific article

Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase

scientific article

Survival and size are differentially regulated by placental and fetal PKBalpha/AKT1 in mice

scientific article published on 27 October 2010

TAZ-mediated crosstalk between Wnt and Hippo signaling

scientific article published in April 2010

Targeting the Kinome II.

scientific article published in April 2009

Ten years of protein kinase B signalling: a hard Akt to follow ⬇️

scientific article published on November 1, 2001

The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas

scientific article published in November 2009

The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B

scientific article

The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics

scientific article

The Hemodynamic Basis for Positional- and Inter-Fetal Dependent Effects in Dual Arterial Supply of Mouse Pregnancies ⬇️

scientific article published on December 20, 2012

The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation

scientific article published on November 2009

The MgATP-Dependent Protein Phosphatase and Protein Phosphatase 1 Have Identical Substrate Specificities ⬇️

scientific article published on March 16, 1981

The PI3K-PKB/Akt pathway

scientific article published in April 2015

The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1.

scientific article

The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products

scientific article published on 01 February 1984

The human tumour suppressor LATS1 is activated by human MOB1 at the membrane

scientific article published on 25 April 2006

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

scientific article

The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C ⬇️

scientific article published on November 15, 2001

Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes

scientific article published on 22 August 2008

Transcriptional regulation of a plasminogen activator gene by cyclic AMP in a homologous cell-free system. Involvement of cyclic AMP-dependent protein kinase in transcriptional control.

scientific article published in February 1988

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

scientific article

Ultrastructural localization of the regulatory (RII) subunit of cyclic AMP-dependent protein kinase to subcellular compartments active in endocytosis and recycling of membrane receptors

scientific article published on August 1990

cAMP mediated proteolysis of the catalytic subunit of cAMP-dependent protein kinase

scientific article

cAMP metabolism in the porcine kidney epithelial cell line LLC-PK1: the central role of the cAMP-dependent protein kinase in cAMP-mediated gene induction

scientific article

cAMP stimulates protein kinase B in a Wortmannin-insensitive manner

scientific article published on 01 June 1997

cAMP-dependent protein kinase activation affects vasopressin V2-receptor number and internalization in LLC-PK1renal epithelial cells ⬇️

scientific article published on April 9, 1991

cAMP-dependent protein kinase regulates renal epithelial cell properties ⬇️

scientific article published on June 1, 1991

hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.

scientific article

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition

scientific article published on 25 May 2017

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

scientific article published on December 2000

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