List of works - Bernard Vanhove

A more selective costimulatory blockade of the CD28-B7 pathway.

scientific article published on 21 October 2010

Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28

scientific article

Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker.

scientific article published on September 2010

Analysis of T cell repertoire in a concordant hamster-to-rat cardiac xenograft model during accommodation and rejection process

scientific article published on 01 February 1999

Antagonist properties of monoclonal antibodies to human CD28: role of valency and heavy-chain constant domain.

scientific article published on 28 November 2012

Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection.

scientific article published on 9 May 2016

Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients

scientific article published on 01 December 2007

Anti-CD28 antibody-induced kidney allograft tolerance related to tryptophan degradation and TCR class II B7 regulatory cells

scientific article

Anti-MHC-II preventing graft rejection

scientific article published on 01 June 1999

Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+) )-activated T lymphocytes prevents delayed-type hypersensitivity in non-human primates.

scientific article

Autoimmune responses against renal tissue proteins in long-term surviving allograft recipients

scientific article published on 16 July 2009

Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons

scientific article

CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity.

scientific article published on 20 September 2017

CD28-Specific Immunomodulating Antibodies: What Can Be Learned From Experimental Models? ⬇️

scientific article published on 04 April 2012

Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression.

scientific article

Clinical efficacy of a new CD28-targeting antagonist of T cell co-stimulation in a non-human primate model of collagen-induced arthritis

article

Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?

scientific article (publication date: 2015)

Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

scientific article published on 17 August 2016

Control of transplant tolerance and intragraft regulatory T cell localization by CCL5.

scientific article published on 28 November 2012

Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5.

scientific article

Correction: Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis

scientific article published in July 2015

Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells

scientific article published on 01 September 2003

Differential regulation of motility and immune synapses by CD28/ CTLA-4 costimulation in effector and regulatory T cells

Differentiation of membrane IgE+ rat B cells into IgE-secreting cells.

scientific article published in August 1993

Direct recognition of foreign MHC determinants by naive T cells mobilizes specific Vbeta families without skewing of the complementarity-determining region 3 length distribution

scientific article published in September 2001

Dominant Tolerance to Kidney Allografts Induced by Anti-Donor MHC Class II Antibodies: Cooperation between T and Non-T CD103+ Cells

article

Endothelial cell protection by dextran sulfate: a novel strategy to prevent acute vascular rejection in xenotransplantation

scientific article published in February 2004

Evaluation of FR104, a Treg sparing antagonist anti-CD28 monovalent Fab’ antibody in kidney transplantation in non-human primates

Expression of Heme Oxygenase‐1 in Neural Stem/Progenitor Cells as a Potential Mechanism to Evade Host Immune Response ⬇️

scientific article published on October 1, 2012

FR104, an antagonist anti-CD28 monovalent fab' antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal allograft

scientific article published on 8 December 2014

First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28.

scientific article published on 14 November 2016

Genetic engineering in the pig. Gene knockout and alternative techniques

scientific article published on 01 December 1998

Graft versus host disease in humanized mice is differentially controlled by CD28 and CD80/86 antagonists

Grammont's reverse shoulder prosthesis for rotator cuff arthropathy. A retrospective study of 32 cases.

scientific article published in June 2004

Human xenoreactive natural antibodies--avidity and targets on porcine endothelial cells

scientific article published on 01 November 1993

IL-7 receptor blockade following T cell depletion promotes long-term allograft survival.

scientific article published on 24 February 2014

IgG2b or IgE molecules can be co-expressed with those of the IgM and IgD isotypes of the membrane of normal rat B cells

scientific article published on 01 January 1992

Immune regulation by non-lymphoid cells in transplantation.

scientific article published on 22 January 2009

Implication of matrix metalloproteinase 7 and the noncanonical wingless-type signaling pathway in a model of kidney allograft tolerance induced by the administration of anti-donor class II antibodies

scientific article published on 01 February 2008

Induction of anti-Forssman antibodies in the hamster-to-rat xenotransplantation model

scientific article published on 01 March 2000

Induction of regulatory cells and control of cellular but not vascular rejection by costimulation blockade in hamster-to-rat heart xenotransplantation

scientific article published in January 2007

Inhibition of cystathionine-γ-lyase controls interleukin-12 production by dendritic cells, delayed-type hypersensitivity and transplant rejection

Inhibition of effector antigen-specific T cells by intradermal administration of heme oxygenase-1 inducers.

scientific article published on 22 March 2017

Intracellular expression in pig cells of anti-alpha1,3galactosyltransferase single-chain FV antibodies reduces Gal alpha1,3Gal expression and inhibits cytotoxicity mediated by anti-Gal xenoantibodies.

scientific article published on December 1998

Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle

scientific article published on 3 November 2009

Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation

scientific article

Localization of the human mitogen-induced GTP-binding protein gem to chromosome 8q22.3.

scientific article published on 01 May 1996

Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts.

scientific article published on 14 August 2013

Mechanisms of tolerance induction: blockade of co-stimulation.

scientific article

Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation

scientific article published in August 2009

Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion

scientific article published on 01 June 2008

Myeloid-derived suppressor cells in transplantation.

scientific article published on December 2010

Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance.

scientific article published on 17 July 2012

Nantes Actualité Transplantation 2006 Summary Report: innovative therapeutics in transplantation

scientific article published on 01 December 2006

Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production

scientific article

Porcine α1,3-galactosyltransferase: tissue-specific and regulated expression of splicing isoforms

scientific article published on 01 March 1997

Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab' antibody

scientific article published on 03 July 2012

Prevention of lupus nephritis development in NZB/NZW mice by selective blockade of CD28.

scientific article published on 20 June 2017

Reply to “Biologics in organ transplantation” ⬇️

scientific article published on November 12, 2012

Risk in drug trials

Rituximab-based first line treatment for chronic GVHD after allogeneic SCT: results of a phase 2 study

scientific article published on September 2017

Selective CD28 Antagonist Blunts Memory Immune Responses and Promotes Long-Term Control of Skin Inflammation in Nonhuman Primates.

scientific article published on 23 November 2015

Selective CD28 antagonist prevents Aldara-induced skin inflammation in non-human primates

scientific article published on 10 February 2016

Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses

scientific article

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

scientific article published on 14 January 2015

T cell repertoire alterations in allograft and xenograft rejection processes

scientific article published on 01 August 2000

T cell repertoire alterations of vascularized xenografts

scientific article published on 01 March 1999

T-cell-mediated rejection of vascularized xenografts in the absence of induced anti-donor antibody response

scientific article published on 01 May 2001

TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model

scientific article published on 11 May 2011

Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells

scientific article

Targeting the CD80/CD86 costimulatory pathway with CTLA4-Ig directs microglia toward a repair phenotype and promotes axonal outgrowth.

scientific article

Technology evaluation: Belatacept, Bristol-Myers Squibb

scientific article published in August 2005

Transcriptional and posttranscriptional regulation of alpha 1,3-galactosyltransferase in activated endothelial cells results in decreased expression of Gal alpha 1,3Gal.

scientific article

Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation.

scientific article published on August 2005

Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses.

scientific article published on 19 January 2012

Understanding rejection of xenografts

scientific article published on 01 September 2000

Variability of alpha 1,3-galactosyltransferase splicing isoforms in pig tissues

scientific article published on 01 April 1996

Xenotransplantation of Galactosyl-Transferase Knockout, CD55, CD59, CD39, and Fucosyl-Transferase Transgenic Pig Kidneys Into Baboons

scientific article published on 01 November 2011

[Monoclonal antibodies in organ transplantation]

scientific article published on 01 December 2009

[Next generation of anti-immune checkpoints antibodies]

scientific article published on 01 December 2019

[On the acceptability of xenografts]

scientific article published on 01 March 2005

hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model

scientific article published on 08 July 2014

List of works by Bernard Vanhove

A more selective costimulatory blockade of the CD28-B7 pathway.

Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28

Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker.

Analysis of T cell repertoire in a concordant hamster-to-rat cardiac xenograft model during accommodation and rejection process

Antagonist properties of monoclonal antibodies to human CD28: role of valency and heavy-chain constant domain.

Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection.

Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients

Anti-CD28 antibody-induced kidney allograft tolerance related to tryptophan degradation and TCR class II B7 regulatory cells

Anti-MHC-II preventing graft rejection

Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+) )-activated T lymphocytes prevents delayed-type hypersensitivity in non-human primates.

Autoimmune responses against renal tissue proteins in long-term surviving allograft recipients

Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons

CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity.

CD28-Specific Immunomodulating Antibodies: What Can Be Learned From Experimental Models? ⬇️

Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression.

Clinical efficacy of a new CD28-targeting antagonist of T cell co-stimulation in a non-human primate model of collagen-induced arthritis

Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?

Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

Control of transplant tolerance and intragraft regulatory T cell localization by CCL5.

Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5.

Correction: Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis

Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells

Differential regulation of motility and immune synapses by CD28/ CTLA-4 costimulation in effector and regulatory T cells

Differentiation of membrane IgE+ rat B cells into IgE-secreting cells.

Direct recognition of foreign MHC determinants by naive T cells mobilizes specific Vbeta families without skewing of the complementarity-determining region 3 length distribution

Dominant Tolerance to Kidney Allografts Induced by Anti-Donor MHC Class II Antibodies: Cooperation between T and Non-T CD103+ Cells

Endothelial cell protection by dextran sulfate: a novel strategy to prevent acute vascular rejection in xenotransplantation

Evaluation of FR104, a Treg sparing antagonist anti-CD28 monovalent Fab’ antibody in kidney transplantation in non-human primates

Expression of Heme Oxygenase‐1 in Neural Stem/Progenitor Cells as a Potential Mechanism to Evade Host Immune Response ⬇️

FR104, an antagonist anti-CD28 monovalent fab' antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal allograft

First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28.

Genetic engineering in the pig. Gene knockout and alternative techniques

Graft versus host disease in humanized mice is differentially controlled by CD28 and CD80/86 antagonists

Grammont's reverse shoulder prosthesis for rotator cuff arthropathy. A retrospective study of 32 cases.

Human xenoreactive natural antibodies--avidity and targets on porcine endothelial cells

IL-7 receptor blockade following T cell depletion promotes long-term allograft survival.

IgG2b or IgE molecules can be co-expressed with those of the IgM and IgD isotypes of the membrane of normal rat B cells

Immune regulation by non-lymphoid cells in transplantation.

Implication of matrix metalloproteinase 7 and the noncanonical wingless-type signaling pathway in a model of kidney allograft tolerance induced by the administration of anti-donor class II antibodies

Induction of anti-Forssman antibodies in the hamster-to-rat xenotransplantation model

Induction of regulatory cells and control of cellular but not vascular rejection by costimulation blockade in hamster-to-rat heart xenotransplantation

Inhibition of cystathionine-γ-lyase controls interleukin-12 production by dendritic cells, delayed-type hypersensitivity and transplant rejection

Inhibition of effector antigen-specific T cells by intradermal administration of heme oxygenase-1 inducers.

Intracellular expression in pig cells of anti-alpha1,3galactosyltransferase single-chain FV antibodies reduces Gal alpha1,3Gal expression and inhibits cytotoxicity mediated by anti-Gal xenoantibodies.

Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle

Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation

Localization of the human mitogen-induced GTP-binding protein gem to chromosome 8q22.3.

Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts.

Mechanisms of tolerance induction: blockade of co-stimulation.

Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation

Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion

Myeloid-derived suppressor cells in transplantation.

Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance.

Nantes Actualité Transplantation 2006 Summary Report: innovative therapeutics in transplantation

Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production

Porcine α1,3-galactosyltransferase: tissue-specific and regulated expression of splicing isoforms

Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab' antibody

Prevention of lupus nephritis development in NZB/NZW mice by selective blockade of CD28.

Reply to “Biologics in organ transplantation” ⬇️

Risk in drug trials

Rituximab-based first line treatment for chronic GVHD after allogeneic SCT: results of a phase 2 study

Selective CD28 Antagonist Blunts Memory Immune Responses and Promotes Long-Term Control of Skin Inflammation in Nonhuman Primates.

Selective CD28 antagonist prevents Aldara-induced skin inflammation in non-human primates

Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

T cell repertoire alterations in allograft and xenograft rejection processes

T cell repertoire alterations of vascularized xenografts

T-cell-mediated rejection of vascularized xenografts in the absence of induced anti-donor antibody response

TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model

Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells

Targeting the CD80/CD86 costimulatory pathway with CTLA4-Ig directs microglia toward a repair phenotype and promotes axonal outgrowth.

Technology evaluation: Belatacept, Bristol-Myers Squibb

Transcriptional and posttranscriptional regulation of alpha 1,3-galactosyltransferase in activated endothelial cells results in decreased expression of Gal alpha 1,3Gal.

Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation.

Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses.

Understanding rejection of xenografts

Variability of alpha 1,3-galactosyltransferase splicing isoforms in pig tissues

Xenotransplantation of Galactosyl-Transferase Knockout, CD55, CD59, CD39, and Fucosyl-Transferase Transgenic Pig Kidneys Into Baboons

[Monoclonal antibodies in organ transplantation]