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List of works by Jan H Beumer

<i>ALDH1A1</i> Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper

scientific article published on 28 January 2022

A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas ⬇️

scientific article published on February 3, 2012

A Phase I clinical trial of the combination of imatinib and paclitaxel in patients with advanced or metastatic solid tumors refractory to standard therapy.

scientific article published on 27 September 2012

A high-performance liquid chromatography-mass spectrometry assay for quantitation of the tyrosine kinase inhibitor nilotinib in human plasma and serum.

scientific article published on 21 May 2009

A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum

scientific article published on 24 May 2006

A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay

scientific article published on 20 January 2012

A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice

scientific article published on 01 October 2006

A pharmacokinetic analysis of cisplatin and 5-fluorouracil in a patient with esophageal cancer on peritoneal dialysis.

scientific article published on 21 December 2015

A phase 1 trial of imatinib, bevacizumab, and metronomic cyclophosphamide in advanced colorectal cancer

scientific article published on 10 September 2013

A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction

scientific article published on 04 September 2019

A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, administered with tetrahydrouridine

scientific article

A phase II trial of dasatinib in patients with metastatic castration-resistant prostate cancer treated previously with chemotherapy.

scientific article

A phase i study of DMS612, a novel bifunctional alkylating agent

scientific article

A phase-1 study of dasatinib plus all-trans retinoic acid in acute myeloid leukemia.

scientific article published on 4 April 2018

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells

scientific article published on 14 May 2015

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy

scientific article published on 19 March 2014

ATM serine-1981 phosphorylation is a plausible biomarker

scientific article published on October 2015

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

scientific article

An Automated Homogeneous Immunoassay for Quantitating Imatinib Concentrations in Plasma.

scientific article published on August 2015

Biomarkers of Phenethyl Isothiocyanate-Mediated Mammary Cancer Chemoprevention in a Clinically Relevant Mouse Model ⬇️

scientific article published on August 2, 2012

Body-surface area-based chemotherapy dosing: appropriate in the 21st century?

scientific article

CYP24 inhibition preserves 1α,25-dihydroxyvitamin D(3) anti-proliferative signaling in lung cancer cells.

scientific article

Calcium carbonate does not affect imatinib pharmacokinetics in healthy volunteers

scientific article published on 30 October 2013

Calcium carbonate does not affect nilotinib pharmacokinetics in healthy volunteers

scientific article published on 14 September 2013

Characterization of the metabolism of benzaldehyde dimethane sulfonate (NSC 281612, DMS612).

scientific article

Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

scientific article

Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis.

scientific article

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

scientific article

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

scientific article published on 26 September 2007

Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.

scientific article published on 24 February 2009

Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome

scientific article published on 01 July 2006

Effect of Renal Dysfunction on Toxicity in Three Decades of Cancer Therapy Evaluation Program-Sponsored Single-Agent Phase I Studies

scientific article published on 21 September 2015

Effect of a proton pump inhibitor on the pharmacokinetics of imatinib

scientific article published on September 2009

Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103).

scientific article

Effect of antacid on imatinib absorption

scientific article published on 24 May 2008

Effects of the aldehyde dehydrogenase inhibitor disulfiram on the plasma pharmacokinetics, metabolism, and toxicity of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice

scientific article published on 24 September 2013

Erratum to: Phase I and pharmacokinetic evaluation of the anti-telomerase agent KML-001 with cisplatin in advanced solid tumors

scientific article published on 01 November 2016

Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi

scientific article published on 24 April 2018

Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743).

scientific article

Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker

scientific article published on 18 September 2020

Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines

scientific article published on 5 October 2012

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma

scientific article published on 5 October 2015

Halofuginone infused keratin hydrogel attenuates adhesions in a rodent cecal abrasion model

scientific article published on 10 August 2012

Hepatotoxicity and metabolism of trabectedin: a literature review.

scientific article

Human hepatocyte assessment of imatinib drug-drug interactions - complexities in clinical translation

scientific article

Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry

scientific article published on 19 January 2016

Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.

scientific article published on 9 March 2007

Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.

scientific article published in August 2005

Imatinib mesylate pharmacokinetics before and after sleeve gastrectomy in a morbidly obese patient with chronic myeloid leukemia.

scientific article published in September 2009

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization ⬇️

scientific article published on August 26, 2010

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4-p53 interaction

scientific article published on 07 June 2015

In vitro evaluation of the metabolic enzymes and drug interaction potential of triapine

scientific article published on 28 September 2020

LC-MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma.

scientific article published on 18 July 2016

LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma

scientific article published on 9 April 2013

LC-MS/MS assay for the quantitation of the tyrosine kinase inhibitor neratinib in human plasma

scientific article published on 22 November 2016

Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase

scientific article published on 31 July 2008

Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776.

scientific article

Mass balance studies, with a focus on anticancer drugs.

scientific article

Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.

scientific article published in June 2008

NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma

scientific article published on 30 July 2018

Neratinib plus Cetuximab in Quadruple WT (KRAS, NRAS, BRAF, PIK3CA) Metastatic Colorectal Cancer Resistant to Cetuximab or Panitumumab: NSABP FC-7, A Phase Ib Study

scientific article published on 17 November 2020

Oral and intravenous pharmacokinetics of 5-fluoro-2'-deoxycytidine and THU in cynomolgus monkeys and humans

scientific article

Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice

scientific article published on 30 November 2006

Pharmacotherapy in cancer patients with HIV/AIDS

scientific article

Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer

scientific article

Phase I and pharmacokinetic evaluation of the anti-telomerase agent KML-001 with cisplatin in advanced solid tumors

scientific article published on 12 September 2016

Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer ⬇️

scientific article published on July 17, 2012

Phase I study of vorinostat in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group study

scientific article

Phase I trial of daily triapine in combination with cisplatin chemotherapy for advanced-stage malignancies

scientific article

Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl+ hematological malignancies.

scientific article

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer

scientific article

Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer.

scientific article

Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.

scientific article

Plasma pharmacokinetics and tissue and brain distribution of cisplatin in musk shrews

scientific article

Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs

scientific article published on 17 March 2015

Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer.

scientific article

Potential interactions between HIV drugs, ritonavir and efavirenz and anticancer drug, nilotinib--a study in primary cultures of human hepatocytes that is applicable to HIV patients with cancer

scientific article published on 27 May 2014

Preclinical assessment of the interactions between the antiretroviral drugs, ritonavir and efavirenz, and the tyrosine kinase inhibitor erlotinib.

scientific article

Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spe

scientific article published on January 2004

Quantitative method for the determination of iso-fludelone (KOS-1803) in human plasma by LC-MS/MS.

scientific article

Reply to V. Launay-Vacher, T. Shimokata et al, and C. Porta et al.

scientific article

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer

scientific article published on 02 August 2013

Role of PARP Inhibitors in Cancer Biology and Therapy ⬇️

scientific article published on January 1, 2012

Role of histone deacetylases and their inhibitors in cancer biology and treatment.

scientific article published on August 2010

Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis ⬇️

scientific article published on November 21, 2012

Targeting p53-dependent stem cell loss for intestinal chemoprotection.

scientific article published in February 2018

The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment

scientific article

Therapeutic drug monitoring of 5-fluorouracil.

scientific article published on 23 May 2016

Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation

scientific article published on 24 October 2016

Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.

scientific article

Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia

scientific article

Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Practical Clinical Implications of Pharmacologic Features

scientific article

VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells

scientific article

Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial

scientific article

Without therapeutic drug monitoring, there is no personalized cancer care

scientific article published on 01 March 2013

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