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List of works by Markus Müschen

A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias

scientific article

A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential

scientific article

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine

scientific article published on January 2014

Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia

scientific article

Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells

scientific article published on 07 May 2007

American Journal of Blood Research: Editorial Board (2011) e-Century Publishing Corporation ⬇️

scientific article published on June 13, 2011

An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

scientific article published on 03 February 2022

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival

scientific article published on 3 April 2017

Autoimmunity checkpoints as therapeutic targets in B cell malignancies

scientific article published on 5 January 2018

B-cell identity as a metabolic barrier against malignant transformation

scientific article published on 24 June 2017

BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

scientific article

BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint

scientific article published on 10 December 2013

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition

scientific article published on May 2011

BCL6 is critical for the development of a diverse primary B cell repertoire

scientific article

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

scientific article

Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation

scientific article

Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1 ⬇️

scientific article published on December 8, 2011

Core transcriptional regulatory circuitries in cancer

scientific article published on 17 September 2020

Correction: Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

scientific article published on 8 September 2017

Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells

scientific article

Diet-Induced Obesity Accelerates Acute Lymphoblastic Leukemia Progression in Two Murine Models ⬇️

scientific article published on September 7, 2010

Effects of pharmacological and genetic disruption of CXCR4 chemokine receptor function in B-cell acute lymphoblastic leukaemia

scientific article published on 12 April 2016

Epstein-Barr virus and the B cell: a secret romance

scientific article published in June 2003

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

scientific article published on 11 June 2015

Follicular lymphoma: too many reminders for a memory B cell

scientific article

Genetic relicts from the origin of ALL.

scientific article

Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling

scientific article

High-resolution characterization of gene function using single-cell CRISPR tiling screen

scientific article published on 01 July 2021

Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin

scientific article

IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

scientific article published on 04 November 2020

IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia

scientific article

Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK.

scientific article published on 28 December 2016

Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.

scientific article published on 9 October 2014

Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations

scientific article

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia

scientific article

Infection and the Perils of B-cell Activation

scientific article published on December 2015

Infectious origins of childhood leukemia

scientific article published on July 2015

Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

scientific article published on 05 December 2019

Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

scientific article published on 25 February 2016

Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples

scientific article published on 13 September 2010

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia

scientific article published on 29 October 2012

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

scientific article published on 14 January 2013

Interference of BCR-ABL1 kinase activity with antigen receptor signaling in B cell precursor leukemia cells.

scientific article published on 25 July 2004

Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors

scientific article published on February 2017

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

scientific article

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

scientific article

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

scientific article published on 18 May 2015

Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia

scientific article

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

scientific article

Metabolic gatekeepers to safeguard against autoimmunity and oncogenic B cell transformation

scientific article published on 01 May 2019

Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells

scientific article

Molecular portraits of B cell lineage commitment

scientific article

Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia

scientific article

Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

scientific article published on 10 February 2016

O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia

scientific article published on 11 March 2013

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

scientific article published on 14 March 2016

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

scientific article

Ph+ ALL: drawing strength from a benign past

scientific article

Portending death in germinal centers - when B cells know their time is up.

scientific article published in December 2017

Pre-B cell receptor signaling in acute lymphoblastic leukemia

scientific article published on 9 December 2009

Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.

scientific article

Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function

scientific article published on 20 July 2009

RETRACTED: Silencing of B cell receptor signals in human naive B cells

retracted scientific article

Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia

scientific article published on 15 April 2015

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species

scientific article

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations

scientific article

SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia ⬇️

scientific article published on November 14, 2012

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

scientific article

Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia

scientific article

Signalling input from divergent pathways subverts B cell transformation

scientific article published on 22 July 2020

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

scientific article published on 23 March 2015

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

scientific article published on 24 June 2020

T lymphoid differentiation in human bone marrow ⬇️

scientific article published on May 8, 2003

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

scientific article published on 09 September 2021

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia

scientific article

Targeting the B-cell receptor signaling pathway in B lymphoid malignancies

scientific article

The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia

scientific article

The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells

scientific article

The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells

scientific article

The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion

scientific article

The origin of CD95-gene mutations in B-cell lymphoma

scientific article published in February 2002

Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement

scientific article

Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia

scientific article published on 24 August 2017

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

scientific article published on 22 April 2015

mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL.

scientific article

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