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List of works by Steffen Koschmieder

A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells

scientific article published on 7 March 2014

A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis

scientific article published on 16 June 2015

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

scientific article

A phase Ib study to assess the efficacy and safety of vismodegib in combination with ruxolitinib in patients with intermediate- or high-risk myelofibrosis

scientific article published on 24 September 2018

A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease

scientific article published on 10 January 2020

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein

scientific article published on 18 January 2011

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms

scientific article published on 14 December 2014

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

scientific article published on 05 May 2011

Allogeneic stem cell transplant to eliminate germline mutations in the gene for CCAAT-enhancer-binding protein α from hematopoietic cells in a family with AML

scientific article published on 01 April 2011

Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia

scientific article published on 17 November 2016

BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance.

scientific article published on 17 March 2016

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

scientific article

Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry.

scientific article published on 5 March 2016

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow.

scientific article published on 19 January 2018

Bosutinib: A Potent Second-Generation Tyrosine Kinase Inhibitor

scientific article published on 01 January 2018

Bosutinib: a novel second-generation tyrosine kinase inhibitor

scientific article published on January 2014

CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia

scientific article

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha

scientific article

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

scientific article published on 13 May 2016

Cancer Screening in Patients with Idiopathic Venous Thromboembolism--a Position Paper of the German Society of Hematology and Oncology Working Group on Hemostasis

scientific article published on 05 August 2015

Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.

scientific article published on 29 April 2013

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

scientific article published on 19 December 2011

Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

scientific article

Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid Leukemia

scientific article

Combined plasmapheresis and immunosuppression as rescue treatment of a patient with catastrophic antiphospholipid syndrome occurring despite anticoagulation: a case report

scientific article published in June 2003

Comparison of flow-FISH and MM-qPCR telomere length assessment techniques for the screening of telomeropathies

scientific article published on 24 October 2019

Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes

scientific article published on 3 December 2010

Construction and application of an inducible system for homogenous expression levels in bulk cell lines

scientific article

Contemporary insights into the pathogenesis and treatment of chronic myeloproliferative neoplasms

scientific article published on 31 May 2016

Coordination of cell growth in cocultures by a genetic proliferation control system

scientific article published on May 2002

Correction: Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot study

scientific article published on 10 July 2020

Defective megakaryocytic development in myelodysplastic syndromes

scientific article

Dexamethasone nanomedicines for COVID-19

scientific article published on 03 August 2020

Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thro

scientific article

Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells

scientific article published on April 2002

Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

scientific article published on 02 April 2019

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.

scientific article published on 14 August 2017

Dissecting Genomic Aberrations in Myeloproliferative Neoplasms by Multiplex-PCR and Next Generation Sequencing

scientific article published on 20 April 2015

Drug target optimization in chronic myeloid leukemia using innovative computational platform

scientific article published on 3 February 2015

Dysregulation of the C/EBPalpha differentiation pathway in human cancer

scientific article published on 15 December 2008

Efficacy and toxicity of a rituximab and methotrexate based regimen (GMALL B-ALL/NHL 2002 protocol) in Burkitt's and primary mediastinal large B-cell lymphoma

scientific article published on 02 September 2011

Emerging translational science discoveries, clonal approaches, and treatment trends in chronic myeloproliferative neoplasms

scientific article published on 20 June 2019

Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.

scientific article published on 04 September 2013

Epigenetic biomarker to support classification into pluripotent and non-pluripotent cells.

scientific article

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options.

scientific article published in August 2017

Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia

scientific article

Favorable COVID-19 course despite significant comorbidities in a ruxolitinib-treated patient with primary myelofibrosis

scientific article published on 27 June 2020

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study

scientific article

Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot study

scientific article published on 30 May 2020

Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model.

scientific article published on 29 April 2016

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene

scientific article published on 29 December 2011

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

scientific article published on 29 March 2013

Health care setting and severity, symptom burden, and complications in patients with Philadelphia-negative myeloproliferative neoplasms (MPN): a comparison between university hospitals, community hospitals, and office-based physicians.

scientific article published on 22 June 2016

Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l

scientific article published on 04 June 2019

High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib

scientific article published on 07 January 2021

Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms

scientific article published on 14 November 2019

IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21

scientific article published in August 2000

Identification of the Adapter Molecule MTSS1 as a Potential Oncogene-Specific Tumor Suppressor in Acute Myeloid Leukemia

scientific article published on 21 May 2015

Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study

scientific article

Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival

scientific article published on 22 December 2010

Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome

scientific article

Induction therapy of AML with ara-C plus daunorubicin versus ara-C plus gemtuzumab ozogamicin: a randomized phase II trial in elderly patients

scientific article published on 02 August 2011

Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia

scientific article published on 04 July 2019

Inhibition of phosphotyrosine phosphatase 1B causes resistance in BCR-ABL-positive leukemia cells to the ABL kinase inhibitor STI571.

scientific article published on April 2006

Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling

scientific article

Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements

scientific article

Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells

scientific article

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

scientific article published on 18 October 2016

JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms

scientific article published on April 2015

JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms

scientific article published on 01 November 2019

JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation

article

Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches

scientific article published on 14 September 2020

LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia

scientific article published on 06 November 2019

Leukocyte Counts Based on DNA Methylation at Individual Cytosines.

scientific article published on 8 November 2017

Long-term results of a prospective randomized trial evaluating G-CSF priming in intensive induction chemotherapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia.

scientific article

Low SMC1A protein expression predicts poor survival in acute myeloid leukemia.

scientific article published in July 2010

Macrophage frequency in the bone marrow correlates with morphologic subtype of myeloproliferative neoplasm

scientific article published on 26 October 2020

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells

scientific article published on 16 January 2017

Molecular monitoring in NUP214-ABL-positive T-acute lymphoblastic leukemia reveals clonal diversity and helps to guide targeted therapy.

scientific article

Mouse models as tools to understand and study BCR-ABL1 diseases.

scientific article published on 07 June 2011

Mtss1 is a critical epigenetically regulated tumor suppressor in CML.

scientific article published on December 2015

Mtss1(CSC156) mutant mice fail to display efficient Mtss1 protein depletion.

scientific article published on 7 February 2017

Mutant NRAS Q61K is responsible for MAPK pathway activation in the MARIMO cell line and renders these cells independent of the CALR-MPL-JAK2-STAT5 pathway

scientific article published on 08 August 2018

Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer

scientific article

Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both

scientific article published on 8 February 2016

NK cells are dysfunctional in human chronic myelogenous leukemia before and on imatinib treatment and in BCR-ABL-positive mice.

scientific article published on 9 September 2011

Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease

scientific article published on 11 January 2011

Older patients with chronic myeloid leukemia (≥65 years) profit more from higher imatinib doses than younger patients: a subanalysis of the randomized CML-Study IV.

scientific article

POEMS syndrome treated with melphalan high-dose therapy and autologous blood stem cell transplantation: a single-institution experience

scientific article published on 29 April 2012

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

scientific article published on 03 September 2013

Patient-customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

scientific article published on 26 February 2018

Perioperative intravenous immunoglobulin treatment in a patient with severe acquired von Willebrand syndrome: case report and review of the literature

scientific article published on 30 March 2017

Phase II clinical trial of pazopanib in patients with acute myeloid leukemia (AML), relapsed or refractory or at initial diagnosis without an intensive treatment option (PazoAML)

scientific article published on 21 March 2019

Philadelphia chromosome-negative classical myeloproliferative neoplasms: revised management recommendations from European LeukemiaNet.

scientific article published on 27 February 2018

Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model

scientific article published on 9 March 2010

Ponatinib in the Treatment of Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Leukemia: Recommendations of a German Expert Consensus Panel with Focus on Cardiovascular Management

scientific article published on 07 October 2019

Potential Technologies Review: A hybrid information retrieval framework to accelerate demand-pull innovation in biomedical engineering

scientific article published on 02 June 2019

Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia

scientific article

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia

scientific article

Prophylaxis and management of venous thromboembolism in patients with myeloproliferative neoplasms: consensus statement of the Haemostasis Working Party of the German Society of Hematology and Oncology (DGHO), the Austrian Society of Hematology and O

article

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

scientific article

Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms.

scientific article published on 14 February 2018

Recurrent somatic mutations are rare in patients with cryptic dyskeratosis congenita

scientific article published on 02 April 2018

Role of Inflammatory Factors during Disease Pathogenesis and Stem Cell Transplantation in Myeloproliferative Neoplasms

scientific article published on 12 August 2020

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.

scientific article published on 17 October 2017

S100A2 induces metastasis in non-small cell lung cancer

scientific article published in January 2009

Safety and efficacy of the combination of sonidegib and ruxolitinib in myelofibrosis: a phase 1b/2 dose-finding study

scientific article published on 01 July 2020

Secondary acute myeloid leukaemia with monosomy 7 in identical adult twins

scientific article

Serum of myeloproliferative neoplasms stimulates hematopoietic stem and progenitor cells.

scientific article

Spontaneous conception and live birth after gonadotoxic chemotherapy for an aggressive bilateral ovarian Burkitt's lymphoma

scientific article published on 31 May 2011

Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling

scientific article published on 06 March 2019

Telomere length at diagnosis of chronic phase chronic myeloid leukemia (CML-CP) identifies a subgroup with favourable prognostic parameters and molecular response according to the ELN criteria after 12 months of treatment with nilotinib

scientific article published on 15 September 2015

Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia

scientific article published on 01 July 2018

The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia

scientific article published on 18 January 2007

The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer

scientific article published on 6 April 2010

The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues

scientific article

The SCLtTAxBCR-ABL transgenic mouse model closely reflects the differential effects of dasatinib on normal and malignant hematopoiesis in chronic phase-CML patients

scientific article

The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double-blind, double-dummy, symptom study (RELIEF).

scientific article

The impact of myeloproliferative neoplasms (MPNs) on patient quality of life and productivity: results from the international MPN Landmark survey

scientific article published on 5 August 2017

The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma.

scientific article

The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth

scientific article

Therapeutic inhibition of FcγRIIb signaling targets leukemic stem cells in chronic myeloid leukemia

scientific article published on 20 July 2020

Transcriptional alteration of DNA repair genes in Philadelphia chromosome negative myeloproliferative neoplasms

scientific article published on 20 November 2019

Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.

scientific article

Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.

scientific article

[Biobanking requirements from the perspective of the clinician : Experiences in hematology and oncology]

scientific article published on 01 July 2018

[Diagnosis and treatment of polycythemia vera in 2015].

scientific article

[Diagnosis and treatment of polycythemia vera in the year 2015]

scientific article published on 01 October 2015

γ-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm

scientific article published on May 2016

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