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List of works by Roger M. Phillips

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.

scientific article published on October 2003

A critical appraisal of the predictive value of in vitro chemosensitivity assays.

scientific article published on September 1990

A hybrid cellular automaton model of solid tumor growth and bioreductive drug transport

scientific article published in November 2012

A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9

scientific article

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

scientific article published in March 2000

Analysis of cell-cycle kinetics and sulfur amino acid metabolism in methionine-dependent tumor cell lines; the effect of homocysteine supplementation.

scientific article published on April 2004

Anticancer metallohelices: nanomolar potency and high selectivity

scientific article published on 26 October 2015

Asymmetric triplex metallohelices with high and selective activity against cancer cells.

scientific article

Avascular tumour growth dynamics and the constraints of protein binding for drug transportation.

scientific article published on 15 August 2012

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

scientific article published in October 1999

Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity ⬇️

scientific article

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

scientific article published on 4 February 2016

Carbophilic 3-component cascades: access to complex bioactive cyclopropyl diindolylmethanes.

scientific article

Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models

scientific article published on 12 June 2019

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

scientific article published on 28 December 2017

Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids.

scientific article

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

scientific article published on December 2007

Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action.

scientific article published in January 2003

Corrigendum to “Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands” [Canc. Lett. 403 (2017) 98–107] ⬇️

scientific article published on 19 June 2018

Development and characterization of a microfluidic model of the tumour microenvironment

scientific article

Drug delivery in a tumour cord model: a computational simulation ⬇️

scientific article

Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer

scientific article published on 21 June 2017

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands.

scientific article

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

scientific article published on June 1998

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

scientific article

Evaluation of the anti-tumour action and acute toxicity of kosins from Hagenia abyssinica

scientific article published on 01 August 1992

Experimental correlations of in vitro drug sensitivity with in vivo responses to ThioTEPA in a panel of murine colon tumours

scientific article published on 01 January 1988

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).

scientific article

Flavone Acetic Acid: Is Vascular Shutdown the Crucial Mechanism of Action ⬇️

scientific article published on July 1, 1991

Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1).

scientific article published in November 2001

Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies.

scientific article published on 23 May 2007

Health care for all: effective, community supported, healthcare with innovative use of telemedicine technology.

scientific article published in February 2018

Hollow fiber assay for tumor angiogenesis

scientific article published on 01 January 2001

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

scientific article published on January 2014

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis ⬇️

scientific article published on 8 June 2015

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

scientific article published on 12 May 2014

Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

scientific article published on 9 January 2013

Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.

scientific article published on May 2004

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

scientific article

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

scientific article

In vitro and in vivo activity of LS 4477 and LS 4559, novel analogues of the tubulin binder estramustine.

scientific article published in January 2002

In vitro and in vivo responses of a panel of murine colon tumours to TCNU: a positive correlation

scientific article published on 01 August 1988

Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer

scientific article published on 13 March 2019

Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes. ⬇️

scientific article published on 29 February 2016

Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids

scientific article published on 01 July 1997

Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512).

scientific article

Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours

scientific article published on 01 January 1987

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

scientific article published on 01 July 1999

Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma.

scientific article

Mathematical and computational models of drug transport in tumours.

scientific article published on 12 March 2014

Measles virus causes immunogenic cell death in human melanoma.

scientific article

Mechanistic and cytotoxicity studies of group IV β-diketonate complexes.

scientific article published on 29 April 2014

Methionine dependence of tumours: a biochemical strategy for optimizing paclitaxel chemosensitivity in vitro.

scientific article published on 18 January 2006

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

scientific article published in March 2012

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

scientific article published on 8 August 2014

Obtaining archived pathological material for biomedical research.

scientific article

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

scientific article published in December 2004

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

scientific article

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

scientific article published on 01 April 2000

Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours.

scientific article published on January 1997

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands ⬇️

scientific article published on 14 June 2017

Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): comparative analysis of tumor recurrence rates.

scientific article published on 20 February 2009

Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

scientific article published on 26 November 2019

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. ⬇️

scientific article published on 7 January 2014

Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells

scientific article published on 03 July 2018

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

scientific article published on 18 July 2019

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

scientific article

Synthesis and anticancer activity evaluation of η(5)-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands.

scientific article published in February 2015

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine ⬇️

scientific article published on April 2015

Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.

scientific article

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

scientific article

Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.

scientific article

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents.

scientific article published on 27 September 2012

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

scientific article

The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model

scientific article published on 01 March 1991

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

scientific article published on 01 April 2000

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

scientific article published on 11 May 2020

Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts

scientific article published on September 2003

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