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List of works by Cornelius Miething

A novel conditional NPM-ALK-driven model of CD30+ T-cell lymphoma mediated by a translational stop cassette

scientific article published on 21 November 2019

A pipeline for the generation of shRNA transgenic mice

scientific article published on 02 February 2012

A rapid and scalable system for studying gene function in mice using conditional RNA interference

scientific article published on April 2011

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

scientific article

A tumour suppressor network relying on the polyamine-hypusine axis

scientific article

Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.

scientific article

An RNAi-based system for loss-of-function analysis identifies Raf1 as a crucial mediator of BCR-ABL-driven leukemogenesis.

scientific article

Analysing c-kit internalization using a functional c-kit-EGFP chimera containing the fluorochrome within the extracellular domain

scientific article published on July 2002

Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway

scientific article (publication date: 5 April 2002)

CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery.

scientific article published on 15 January 2018

Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27

scientific article

Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies

scientific article

Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

scientific article published on 24 November 2014

Effects of imatinib on bone marrow engraftment in syngeneic mice.

scientific article published in September 2002

Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

scientific article published on 17 March 2020

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

scientific article

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

scientific article

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma

scientific article published on 12 January 2022

Grb10 is involved in BCR-ABL-positive leukemia in mice.

scientific article published on 24 September 2014

Grb4/Nckbeta acts as a nuclear repressor of v-Abl-induced transcription from c-jun/c-fos promoter elements

scientific article (publication date: 16 November 2001)

High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia.

scientific article published in February 1998

High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome

scientific article published on 01 August 1997

Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA)

scientific journal article

Imatinib and leptomycin B are effective in overcoming imatinib-resistance due to Bcr-Abl amplification and clonal evolution but not due to Bcr-Abl kinase domain mutation

scientific article

Imatinib mesylate (STI571) prevents the mutator phenotype of Bcr-Abl in hematopoietic cell lines

scientific article published on April 2004

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets

scientific article published on 27 September 2021

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

scientific article published on 15 May 2003

Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors.

scientific article published on 3 February 2018

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

scientific article

NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma

scientific article published on 18 May 2006

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

scientific article published in February 2018

PTEN action in leukaemia dictated by the tissue microenvironment

scientific article

Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells.

scientific article

Phosphorylation of tyrosine 393 in the kinase domain of Bcr-Abl influences the sensitivity towards imatinib in vivo.

scientific article published on September 2003

RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.

scientific article published on 25 February 2013

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

scientific article published in 2024

Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment

scholarly article

Senescence of activated stellate cells limits liver fibrosis

scientific article

Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.

scientific article published on 27 March 2003

Targeting the oncogenic tyrosine kinase NPM-ALK in lymphoma: the role of murine models in defining pathogenesis and treatment options

scientific article published on October 2006

The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib.

scientific article published on April 2006

The coexpression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia

scientific article published on 01 May 2002

The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model

scientific article published in July 2003

Unexpected dissemination patterns in lymphoma progression revealed by serial imaging within a murine lymph node.

scientific article published on 2 October 2012

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