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List of works by Barbara Cannon

'Neuropeptide tyrosine' (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue

scientific article published on 01 June 1986

A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

scientific article

A direct comparison between peroxisomal and mitochondrial preferences for fatty-acyl beta-oxidation predicts channelling of medium-chain and very-long-chain unsaturated fatty acids to peroxisomes

scientific article published on 01 October 1984

A dual component analysis explains the distinctive kinetics of cAMP accumulation in brown adipocytes

scientific article published on 01 December 1999

A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity

scientific article

A new role for lipocalin prostaglandin d synthase in the regulation of brown adipose tissue substrate utilization.

scientific article

A novel principle for conferring selectivity to poly(A)-binding proteins: interdependence of two ATP synthase beta-subunit mRNA-binding proteins.

scientific article published on February 2000

A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNA

scientific article published on 04 June 2008

A stringent validation of mouse adipose tissue identity markers.

scientific article

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance

scientific article (publication date: November 2006)

Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice.

scientific article published on 5 July 2017

Adrenergic receptor density in brown adipose tissue of active and hibernating hamsters and ground squirrels.

scientific article published on 28 November 2006

Adrenergic stimulation of lipoprotein lipase gene expression in rat brown adipocytes differentiated in culture: mediation via beta3- and alpha1-adrenergic receptors

scientific article

Alpha-adrenergic effects on 86Rb+ (K+) potentials and fluxes in brown fat cells

scientific article published on 01 July 1984

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

scientific article

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

scientific article published on 17 April 2017

An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice

scientific article published on 29 August 2016

Analysis of inhibition by H89 of UCP1 gene expression and thermogenesis indicates protein kinase A mediation of beta(3)-adrenergic signalling rather than beta(3)-adrenoceptor antagonism by H89.

scientific article

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice

scientific article

Apparent unmasking of [3H]GDP binding in rat brown-fat mitochondria is due to mitochondrial swelling

scientific article published on 01 May 1987

As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor

scientific article

BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions

scientific article

Benidipine induces thermogenesis in brown adipose tissue by releasing endogenous noradrenaline: a possible mechanism for the anti-obesity effect of calcium antagonists

scientific article published on 01 March 1999

Beta-adrenergic stimulation of fatty acid release from brown fat cells differentiated in monolayer culture

scientific article published on 01 February 1986

Beta-adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1.

scientific article

Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine

scientific article published on 01 May 1989

Brown adipose tissue as a heat-producing thermoeffector

scientific article published on 01 January 2018

Brown adipose tissue thermogenesis in neonatal and cold-adapted animals

scientific article published on 01 April 1986

Brown adipose tissue. More than an effector of thermogenesis?

scientific article

Brown adipose tissue: function and physiological significance

scientific article (publication date: 2004)

Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively.

scientific article published on November 2006

Carteolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes.

scientific article published in April 1998

Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness.

scientific article published on 8 June 2010

Cell proliferation and apoptosis inhibition: essential processes for recruitment of the full thermogenic capacity of brown adipose tissue

scientific article published on 14 June 2018

Choline+ is a low-affinity ligand for alpha 1-adrenoceptors

scientific article published on 01 October 1994

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

scientific article

Cidea improves the metabolic profile through expansion of adipose tissue

scientific article

Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue.

scientific article published in December 1997

Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

scientific article

Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment.

scientific article published on March 1996

Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice

article

Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues

scientific article published on 01 December 2014

Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function

scientific article published on 15 September 2006

Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.

scientific article published on 20 November 2003

Development of brown fat cells in monolayer culture. I. Morphological and biochemical distinction from white fat cells in culture

scientific article published on 01 November 1983

Developmental biology: Neither fat nor flesh.

scientific article published in August 2008

Differential adrenergic regulation of the gene expression of the beta-adrenoceptor subtypes beta1, beta2 and beta3 in brown adipocytes.

scientific article published on May 2000

Differential regulation of the expression of alpha1-adrenergic receptor subtype genes in brown adipose tissue.

scientific article published on March 1997

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

scientific article

Down-regulation of beta3 adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor

scientific article published on 01 December 1996

Effects of dietary essential fatty acids on active thermogenin content in rat brown adipose tissue

scientific article published on 01 September 1983

Enzyme-linked immunosorbent assay (ELISA) studies of the interaction between mammalian and avian anti-thermogenin antibodies and brown-adipose-tissue mitochondria from different species

scientific article published on 01 January 1984

Epididymal white adipose tissue after cold stress in rats. I. Nonmitochondrial changes

scientific article published on 01 November 1988

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

scientific article published on 10 February 2016

Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups

scientific article published on 01 October 1987

Exclusive occurrence of thermogenin antigen in brown adipose tissue

scientific article published on 01 December 1982

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

scientific article

Halothane selectively inhibits nonshivering thermogenesis. Possible implications for thermoregulation during anesthesia of infants.

scientific article published in February 1995

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

scientific article published on 15 January 2014

Hormone-sensitive lipase in brown adipose tissue: identification and effect of cold exposure

scientific article published on 01 November 1987

How brown is brown fat? It depends where you look.

scientific article published in May 2013

Human brown adipose tissue: Classical brown rather than brite/beige?

scientific article published on 07 May 2020

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

scientific article published on 01 January 2009

IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes.

scientific article published on April 2004

Identification of [3H]prazosin binding sites in crude membranes and isolated cells of brown adipose tissue as alpha 1-adrenergic receptors

scientific article published on 01 August 1983

Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.

scientific article published on 15 February 2017

In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice.

scientific article published on 13 March 2014

Increased respiration in skeletal muscle mitochondria from cold-acclimated ducklings: uncoupling effects of free fatty acids.

scientific article

Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool.

scientific article published on June 1992

Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidation.

scientific article published in August 2004

Leptin Raises Defended Body Temperature without Activating Thermogenesis

scientific article

Leptin-deficient mice are not hypothermic, they are anapyrexic

scientific article published on 9 November 2016

Metabolic consequences of limited substrate anion permeability in brown fat mitochondria from a hibernator, the golden hamster

scientific article published on 01 August 1984

Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans).

scientific article published on October 2010

Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria

scientific article published on 4 June 2015

Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform

scientific article published on 31 July 2007

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

scholarly article

Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.

scientific article

Neither brown nor white

scientific article published in Nature

New powers of brown fat: fighting the metabolic syndrome

scientific article published on 01 March 2011

No insulating effect of obesity.

scientific article

Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels

scientific article published on September 2004

Norepinephrine increases glucose transport in brown adipocytes via beta3-adrenoceptors through a cAMP, PKA, and PI3-kinase-dependent pathway stimulating conventional and novel PKCs.

scientific article published on 9 October 2003

Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture

scientific article published on 01 July 1990

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study.

scientific article published on 31 October 2017

PPARgamma in the control of brown adipocyte differentiation.

scientific article

Parallel increases in amount of (3H)GDP binding and thermogenin antigen in brown-adipose-tissue mitochondria of cafeteria-fed rats

scientific article published on 01 August 1984

Partial protection against erucoyl-carnitine inhibition in hamster brown-adipose-tissue mitochondria is due to high CoA levels: a comparison with rat brown-adipose-tissue mitochondria.

scientific article published on January 1986

Peroxisomal beta-oxidation in brown fat

scientific article published on 01 January 1982

Physiological activation of brown adipose tissue destabilizes thermogenin mRNA

scientific article published on 01 November 1987

Promotion of lipid storage rather than of thermogenic competence by fetal versus newborn calf serum in primary cultures of brown adipocytes

scientific article published on 16 July 2018

Quantitative differentiation of alpha- and beta-adrenergic respiratory responses in isolated hamster brown fat cells: evidence for the presence of an alpha 1-adrenergic component

scientific article published on 01 September 1983

ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence.

scientific article published on 24 April 2014

Reply to letter to the editor: at thermoneutrality, neither the lean nor the obese freeze

scientific article published on 01 September 2016

Studies of thermogenesis and mitochondrial function in adipose tissues

scientific article published on 01 January 2008

Sulfonates are low-affinity ligands for the GDP-binding site of brown-fat mitochondria

scientific article published on 01 May 1994

The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.

scientific article

The Environmental Pollutants Perfluorooctane Sulfonate and Perfluorooctanoic Acid Upregulate Uncoupling Protein 1 (UCP1) in Brown-Fat Mitochondria Through a UCP1-Dependent Reduction in Food Intake.

scientific article published on 21 May 2015

The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling")

scientific article published on 01 October 1999

The browning of white adipose tissue: some burning issues

scientific article published on 07 August 2014

The changed metabolic world with human brown adipose tissue: therapeutic visions.

scientific article published on April 2010

The effect of intermittent cold treatment on the adipose tissue of the cat. Apparent transformation from white to brown adipose tissue.

scientific article published in October 1986

The expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue.

scientific article

The interaction between thyroid and brown-fat thermogenesis. Central or peripheral effects?

scientific article published on 01 March 1997

The molecular basis for adrenergic desensitization in hamster brown adipose tissue: uncoupling of adenylate cyclase activation

scientific article published on 01 January 1984

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

scientific article

The β3-adrenergic receptor is dispensable for browning of adipose tissues.

scientific article published on 21 February 2017

Thermogenesis challenges the adipostat hypothesis for body-weight control.

scientific article

Thermogenesis inhibition in brown adipocytes is a specific property of volatile anesthetics.

scientific article published on February 2003

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist.

scientific article published on 20 May 2008

Thyroid hormones: igniting brown fat via the brain

scientific article published on 01 September 2010

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

scientific journal article

UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent.

scientific article

UCP1 in adipose tissues: two steps to full browning.

scientific article published on 18 January 2017

UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.

scientific article published on 27 November 2013

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

scientific article

UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment.

scientific article published on 6 December 2016

UCP1 is essential for adaptive adrenergic nonshivering thermogenesis

scientific article published on 04 April 2006

UCP1 mRNA does not produce heat.

scientific article

UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.

scientific article

UCP1: the original uncoupling protein--and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice.

scientific article

Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice

scientific article published on May 2011

Unexpected evidence for active brown adipose tissue in adult humans

scientific article (publication date: August 2007)

What Ignites UCP1?

scientific article published in November 2017

Yes, even human brown fat is on fire!

scientific article published on 24 January 2012

alpha- and beta-adrenergic control of thermogenin mRNA expression in brown adipose tissue

scientific article published on 01 July 1986

alpha1-Adrenergic stimulation potentiates the thermogenic action of beta3-adrenoreceptor-generated cAMP in brown fat cells

scientific article published on 01 December 1997

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