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List of works by David E Clapham

1 Intracellular calcium waves

scientific article published on January 1, 1995

A Novel Inward Rectifier K+ Channel with Unique Pore Properties ⬇️

scientific article published on May 1, 1998

A Prokaryotic Voltage-Gated Sodium Channel ⬇️

scientific article (publication date: 14 December 2001)

A STIMulus Package puts orai calcium channels to work.

scientific article published in March 2009

A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel

scientific article published on 01 January 1990

A mysterious new influx factor?

scientific article published in Nature

A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa ⬇️

scientific article published on January 11, 2011

A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte.

scientific article

A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway

scientific article

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

scientific article published on 22 November 2011

A unified nomenclature for the superfamily of TRP cation channels.

scientific article

A voltage-gated ion channel expressed specifically in spermatozoa

scientific article

A voltage-gated proton-selective channel lacking the pore domain

scientific article

Abnormal heart rate regulation in GIRK4 knockout mice.

scientific article published in January 1998

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.

scholarly article

Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells

scientific article

An introduction to TRP channels

scientific article (publication date: 2006)

Analysis of the selectivity filter of the voltage-gated sodium channel NavRh ⬇️

scientific article published on December 18, 2012

Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen

scientific article

At last, the structure of an ion-selective channel

scientific article published on 01 May 1998

Atypical calcium regulation of the PKD2-L1 polycystin ion channel

scientific article published on 27 June 2016

Bisandrographolide from Andrographis paniculata activates TRPV4 channels.

scientific article

Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4

scientific article published on 01 August 2000

CACNA1H mutations in autism spectrum disorders.

scientific article

Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs.

scientific article published on December 1995

CaT1 manifests the pore properties of the calcium-release-activated calcium channel

scientific article published in Nature

Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport

scientific article

Calcium regulation of nuclear pore permeability ⬇️

scientific article published on February 1, 1998

Calcium release and influx colocalize to the endoplasmic reticulum ⬇️

scientific article published on August 1, 1997

Calcium release from the nucleus by InsP3 receptor channels.

scientific article published in January 1995

Calcium signaling

scientific article (publication date: 27 January 1995)

Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse

scientific article

Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. ⬇️

scientific article published on September 2005

Caspase-11 controls interleukin-1β release through degradation of TRPC1.

scientific article

CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm

scientific article

CatSperbeta, a novel transmembrane protein in the CatSper channel complex

scientific journal article

CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility

scientific article

Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes

scientific article published on 01 January 1994

Chloride channels in the nuclear membrane ⬇️

scientific article published on 01 July 1991

Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons

scientific article

Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis

scientific article

Climate change and the integrity of science

scientific article

Cloning and expression of a rat cardiac delayed rectifier potassium channel ⬇️

scientific article published on September 1, 1991

Conformational changes of the in situ nuclear pore complex

scientific article

Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores.

scientific article

Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL.

scientific article

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

scientific article published on 24 July 2019

Cryo-EM structure of the polycystin 2-l1 ion channel

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

scientific article

Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels.

scientific article

Delayed rectifier K+ current in embryonic chick heart ventricle

scientific article published on 01 January 1988

Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis

scientific article published on October 2008

Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages.

scientific article

Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells

scientific article published on 01 December 1979

Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.

scientific article published on 22 November 2006

Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store.

scientific article published in December 1995

Direct G protein activation of ion channels?

scientific article

Direct recording and molecular identification of the calcium channel of primary cilia.

scientific article

EMRE is an essential component of the mitochondrial calcium uniporter complex

scientific article

Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex

scientific article published on 24 July 2014

Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc

scientific article published on 08 June 2020

Essential role for TRPC5 in amygdala function and fear-related behavior.

scientific article

Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.

scientific article published in June 2001

Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel

scientific journal article

Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta

scientific article

Fantastic voyagers? Review of B. C. Crandall and James Lewis, Nanotechnology: Research and Perspectives.

scientific article published in August 1993

Formation of novel TRPC channels by complex subunit interactions in embryonic brain

scientific journal article

Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow

scientific article published on 15 December 2005

Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3.

scientific article

Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.

scientific article

Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway.

scientific article

G beta gamma binds directly to the G protein-gated K+ channel, IKACh

scientific article published on 01 December 1995

G protein activation mechanisms of the cardiac K+ channel, iK.ACh.

scientific article

G protein beta gamma subunits.

scientific article

G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

scientific article (publication date: 9 February 1989)

G-protein regulation of ion channels.

scientific article

G-protein-mediated pathways assayed by electrophysiology and confocal microscopy.

scientific article published on January 1994

Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation

scientific article

Haemodynamic shear stress activates a K+ current in vascular endothelial cells.

scientific article

Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression.

scientific article published on 7 August 2017

How to lose your hippocampus by working on chloride channels.

scientific article published in January 2001

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

scholarly article

Hypotonicity activates a native chloride current in Xenopus oocytes.

scientific article

ICln is essential for cellular and early embryonic viability.

scientific article

Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers

scientific article

In memorium.

scientific article

Influences: Short circuits

scientific article published on 20 March 2018

Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel

scientific article published in Nature

Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view

scientific article

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

scientific article

International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels.

scientific article

International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels ⬇️

scientific article

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

scientific article (publication date: December 2003)

International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels.

scientific article published on December 2003

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels

scientific article

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels.

scientific article published on May 2009

Ion channel regulation by G proteins.

scientific article

Ion channel-kinase TRPM 7 is required for maintaining cardiac automaticity ⬇️

scientific article published on July 22, 2013

Ion channels and calcium signaling in motile cilia.

scientific article published on 9 December 2015

Ion channels--basic science and clinical disease

scientific article (publication date: 29 May 1997)

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus.

scientific article

Isomeric Tuning Yields Bright and Targetable Red Ca2+ Indicators

scientific article published on 23 August 2019

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

scientific article published on 28 May 2013

Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function.

scientific article published on 9 February 2017

MCU encodes the pore conducting mitochondrial calcium currents ⬇️

scientific article published on June 4, 2013

Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development

scientific article

Mechanism of persistent protein kinase D1 translocation and activation

scientific article published on 01 April 2003

Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition

scientific article published on 14 March 2016

Modified herpes simplex virus delivery of enhanced GFP into the central nervous system.

scientific article published in December 2002

Molecular basis of ion permeability in a voltage-gated sodium channel

scientific article published on 12 February 2016

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel ⬇️

scientific article published on March 29, 2013

Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes

scientific article published on April 17, 1992

More pieces of the K+ ion channel puzzle

article published in 1999

Muscarinic-activated K+ current in bovine aortic endothelial cells

scientific article published on 01 June 1988

Naturally Produced Defensive Alkenal Compounds Activate TRPA1.

scientific article published on 3 February 2016

New mammalian chloride channel identified by expression cloning

scientific article published on March 19, 1992

New roles for G-protein beta gamma-dimers in transmembrane signalling.

scientific article

Not so funny anymore: pacing channels are cloned.

scientific article published on July 1998

Nuclear calcium and the regulation of the nuclear pore complex.

scientific article published on September 1997

Nuclear ion channels and regulation of the nuclear pore.

scientific article published on January 1996

Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3.

scientific article published on April 1997

Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh

scientific article

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

scientific article (publication date: May 2006)

Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter

scientific article published on 30 April 2014

POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters

scientific article

Partial structure, chromosome localization, and expression of the mouse Girk4 gene.

scientific article published in March 1997

Perspective: The List of Potential Volume-sensitive Chloride Currents Continues to Swell (and Shrink) ⬇️

scientific article published on May 1, 1998

Phenotyping sensory nerve endings in vitro in the mouse

scientific article

Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line

scientific article published on 01 May 1988

Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.

scientific article

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.

scientific article published on 14 February 2018

Potassium channels in cardiac cells activated by arachidonic acid and phospholipids

scientific article published on 01 June 1989

Primary cilia are not calcium-responsive mechanosensors

scientific article published on 23 March 2016

Primary cilia are specialized calcium signalling organelles

scientific journal article

Progress in ciliary ion channel physiology

scientific article published on 20 December 2016

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

scientific article

Replenishing the stores

scientific article published in Nature

Reply

scientific article published on 01 July 1993

Role of the C-terminal domain in the structure and function of tetrameric sodium channels

scientific article

Roles of G protein subunits in transmembrane signalling.

scientific article

Signal transduction. Hot and cold TRP ion channels.

scientific article

Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa

scientific article published on September 2013

Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes.

scientific article

Small signal impedance of heart cell membranes.

scientific article published in January 1982

Some like it hot: spicing up ion channels ⬇️

scientific article published on October 23, 1997

Sorting out MIC, TRP, and CRAC ion channels.

scientific article

Specificity of receptor-G protein interactions: searching for the structure behind the signal.

scientific article published on September 1993

Sperm BerserKers

scientific article published on 08 October 2013

Sperm Patch-Clamp ⬇️

scientific article published on January 1, 2013

Spiral waves and intracellular calcium signalling

scientific article published on January 1, 1992

Structural biology: Pain-sensing TRPA1 channel resolved.

scientific article

Structural characterization of the mouse Girk genes.

scientific article published on February 2002

Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility

scientific article

Structure of full-length human TRPM4.

scientific article published on 20 February 2018

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structure of the mouse TRPC4 ion channel

scientific article published in Nature Communications

Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh

scientific article (publication date: 30 April 1999)

Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors ⬇️

scientific article published on April 11, 1991

Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells

scientific article published on 01 February 1984

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation

scientific article

TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP

scientific article

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

scientific article

TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation

scientific article

TRP channels and mice deficient in TRP channels

scientific article

TRP ion channels in the nervous system.

scientific article

TRP is cracked but is CRAC TRP?

scientific article published on June 1996

TRPC1 and TRPC5 form a novel cation channel in mammalian brain.

scientific article published on March 2001

TRPC5 is a regulator of hippocampal neurite length and growth cone morphology

scientific article (publication date: August 2003)

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

scientific journal article

TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane.

scientific article

TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles

scientific article published on 10 July 2017

TRPV3 channels mediate strontium-induced mouse-egg activation.

scientific article published on 05 December 2013

TRPV3 is a calcium-permeable temperature-sensitive cation channel.

scientific article

TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis

scientific journal article

Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption.

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The G-protein nanomachine

scientific article published in Nature

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins

scientific article (publication date: 9 March 1995)

The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP

scientific article

The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

scientific article published on 13 November 2003

The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs)

scientific article published on 08 January 2001

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

scientific article published on October 2016

The TRP ion channel family.

scientific article published in June 2001

The TRPM7 channel is inactivated by PIP(2) hydrolysis

scientific article (publication date: May 2002)

The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase

scientific article

The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release

scientific journal article

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

scientific article

The channel kinase, TRPM7, is required for early embryonic development

scientific article published on 27 December 2011

The control of male fertility by spermatozoan ion channels

scientific article published on 13 October 2011

The mitochondrial calcium uniporter is a highly selective ion channel.

scientific article

The molecular control of cardiac ion channels.

scientific article published in January 1997

The mother of all endocytosis.

scientific article published on 26 November 2013

The theoretical small signal impedance of the frog node, Rana pipiens.

scientific article published in November 1976

The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4.

scientific article published on December 2007

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke ⬇️

scientific article published on March 4, 2012

Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain

scientific article published on May 2014

Touch channels sense blood pressure.

scientific article

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

scientific article published on 24 October 2011

Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells

scientific article published on 01 August 1984

Two novel cardiac atrial K+ channels, IK.AA and IK.PC ⬇️

scientific article published on November 1, 1991

Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes ⬇️

scientific article published on February 1, 1992

Unlocking family secrets: K+ channel transmembrane domains.

scientific article

Voltage-activated k channels in embryonic chick heart.

scientific article

Why testicles are cool

scientific article published in Nature

pICln Binds to a Mammalian Homolog of a Yeast Protein Involved in Regulation of Cell Morphology ⬇️

scientific article published on May 1, 1998

pICln inhibits snRNP biogenesis by binding core spliceosomal proteins

scientific article

α‐Helical distorting substitutions disrupt coupling between m3 muscarinic receptor and G proteins ⬇️

scientific article published on June 7, 1993

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