List of works - Li Zhang

A novel mode of chaperone action: heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex.

scientific article

A predictive model of the oxygen and heme regulatory network in yeast

scientific article

A unique mechanism of chaperone action: heme regulation of Hap1 activity involves separate control of repression and activation.

scientific article published on January 2009

Amyloid β perturbs elevated heme flux induced with neuronal development

article

An examination of heme action in gene expression: heme and heme deficiency affect the expression of diverse genes in erythroid k562 and neuronal PC12 cells.

scientific article published in April 2002

Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1.

scientific article

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

scientific article published in Scientific Reports

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

scientific article

DNA supercoiling promotes formation of a bent repression loop in lac DNA.

scientific article published in July 1987

Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance ⬇️

scientific article published on May 17, 2011

Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells

scientific article published on 22 March 2019

Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells

scientific article

Essential roles of mitochondrial and heme function in lung cancer bioenergetics and tumorigenesis

scientific article published on 02 November 2018

Experimental Methods for Studying Cellular Heme Signaling.

scientific article published on 24 May 2018

Functional analysis of heme regulatory elements of the transcriptional activator Hap1

scientific article published on 01 July 2000

Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes

scientific article published on 28 February 2006

Heme controls the regulation of protein tyrosine kinases Jak2 and Src

scientific article

Heme deficiency causes apoptosis but does not increase ROS generation in HeLa cells.

scientific article

Heme initiates changes in the expression of a wide array of genes during the early erythroid differentiation stage

scientific article published on 01 April 1999

Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family.

scientific article

Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins

scientific article published on 22 March 2020

Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes.

scientific article published on 13 March 2014

Hypoxia elicits broad and systematic changes in protein subcellular localization.

scientific article

In situ nucleoprotein structure at the SV40 major late promoter: melted and wrapped DNA flank the start site

scientific article published on 01 November 1989

In situ nucleoprotein structure involving origin-proximal SV40 DNA control elements

scientific article published in April 1990

Learning regulatory programs that accurately predict differential expression with MEDUSA.

scientific article

Measurement of Heme Synthesis Levels in Mammalian Cells

scientific article

Mitochondria Targeting as an Effective Strategy for Cancer Therapy

scientific article published on 09 May 2020

Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1.

scientific article published on July 1998

Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator.

scientific article

Processed electroencephalography: impact of patient age and surgical position on intraoperative processed electroencephalogram monitoring of burst-suppression

scientific article published on 10 July 2021

Rock the nucleus: significantly enhanced nuclear membrane permeability and gene transfection by plasmonic nanobubble induced nanomechanical transduction

scientific article published on 29 January 2018

Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation

scientific article

Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein

scientific article

The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme

scientific article published on December 2001

The Swi3 protein plays a unique role in regulating respiration in eukaryotes.

scientific article

The coiled coil dimerization element of the yeast transcriptional activator Hap1, a Gal4 family member, is dispensable for DNA binding but differentially affects transcriptional activation

scientific article published on 01 January 2000

The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes

scientific article published on 21 June 2006

The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae.

scientific article

The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1.

scientific article published on 7 January 2002

The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation ⬇️

scientific article published on August 29, 2012

The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells

scientific article published on 28 December 2017

The yeast heme-responsive transcriptional activator Hap1 is a preexisting dimer in the absence of heme

scientific article published on 01 August 1999

List of works by Li Zhang

A novel mode of chaperone action: heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex.

A predictive model of the oxygen and heme regulatory network in yeast

A unique mechanism of chaperone action: heme regulation of Hap1 activity involves separate control of repression and activation.

Amyloid β perturbs elevated heme flux induced with neuronal development

An examination of heme action in gene expression: heme and heme deficiency affect the expression of diverse genes in erythroid k562 and neuronal PC12 cells.

Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1.

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

DNA supercoiling promotes formation of a bent repression loop in lac DNA.

Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance ⬇️

Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells

Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells

Essential roles of mitochondrial and heme function in lung cancer bioenergetics and tumorigenesis

Experimental Methods for Studying Cellular Heme Signaling.

Functional analysis of heme regulatory elements of the transcriptional activator Hap1

Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes

Heme controls the regulation of protein tyrosine kinases Jak2 and Src

Heme deficiency causes apoptosis but does not increase ROS generation in HeLa cells.

Heme initiates changes in the expression of a wide array of genes during the early erythroid differentiation stage

Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family.

Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins

Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes.

Hypoxia elicits broad and systematic changes in protein subcellular localization.

In situ nucleoprotein structure at the SV40 major late promoter: melted and wrapped DNA flank the start site

In situ nucleoprotein structure involving origin-proximal SV40 DNA control elements

Learning regulatory programs that accurately predict differential expression with MEDUSA.

Measurement of Heme Synthesis Levels in Mammalian Cells

Mitochondria Targeting as an Effective Strategy for Cancer Therapy

Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1.

Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator.

Processed electroencephalography: impact of patient age and surgical position on intraoperative processed electroencephalogram monitoring of burst-suppression

Rock the nucleus: significantly enhanced nuclear membrane permeability and gene transfection by plasmonic nanobubble induced nanomechanical transduction

Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation

Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein

The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme

The Swi3 protein plays a unique role in regulating respiration in eukaryotes.

The coiled coil dimerization element of the yeast transcriptional activator Hap1, a Gal4 family member, is dispensable for DNA binding but differentially affects transcriptional activation

The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes

The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae.

The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1.

The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation ⬇️

The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells

The yeast heme-responsive transcriptional activator Hap1 is a preexisting dimer in the absence of heme